The regulation of blood pressure and fluid homeostasis in the body occurs thorough an endocrine pathway called the renin angiotensin (RAS) pathway. This is a multistep pathway in which two step conversion of angiotensinogen to angiotensin I by rennin and subsequent conversion of angiotensin I to angiotensin II by angiotensin converting enzyme (ACE) occurs (Fig 1a). The RAS involves a number of peptides, receptors and enzymes partake in this highly regulated system. The angiotensin II, however, is the key biological player of this pathway. Uncontrolled activation and improper regulation of the RAS pathway leads to hypertension, organ failure and eventually death. ...
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