Essays on Carcinogenesis

The Relationship between H. Pylori Infection and Mitochondrial Microsatellite Instability in Gastric Carcinogenesis

Recent research has established that while there are a number of steps that take place in the development of gastric cancer, Helicobacter pylori (H. pylori) plays a major role. However, the mechanism of the influence remains unidentified. Researchers Ling et al. (2016) conducted a study to determine relationships between an infection of H. pylori, IL-8, and mtMSI and whether there is a trigger that causes the infection to progress to intestinal metaplasia, dysplasia, and ultimately to gastric carcinogenesis.   The method used by the researchers included fresh samples from resected gastric cancerous cells and comparison samples of potentially pre-cancerous mucosa; ...

Introduction

The total number of patients with cancer keeps soaring globally with around 14 million cases diagnosed by 2014. Each year, about 8 million people die of cancer-related illnesses globally. There are quite some remedies that have been proposed to mitigate in the cancer menace. This study is focused on cancer treatment by curcumin through tyrosine kinase inhibition. Curcumin is the primary coloring agent found in turmeric, a tuber of the herb Curcuma longa Lin. It has widespread use as a flavoring agent (Aggarwal and Bokyung 87). It is also well known for its medicinal value commonly used to suppress ...