It was originally thought that basal ganglia were responsible for voluntary motor movements, and movement disorders were associated with pathological changes in the basal ganglia. However, it was found that the basal ganglia are associated with different cortexes with distinctive circuits, which are called loops, so a pathological transformation of tissue can manifest as a psychological or motor disorder, depending on the loop affected. The cortico-basal ganglia-thalamocortical loop is a one-way circuit that allows the basal ganglia to receive input from the cortex and send output via the thalamus back to different regions of the cortex. Pathological changes in this loop are ...
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