Abstract
Factor V Leiden is a genetic mutation that confers resistance to the action of activated protein C and thus predisposes to venous thromboembolism. It’s inherited as an autosomal dominant trait and is prevalent amongst Caucasians with a carrier rate of 4%. Deep venous thrombosis and pulmonary embolism are the most common clinical manifestations of FVL related VTE although it can also affect other sites. Genetic testing for FVL is used for diagnostic as well as predictive purposes. Diagnosis of FVL is based on protein assays and
DNA analysis technology. Familial genetic testing for FVL is generally not recommended except in ...
