Aim: To measure the partition coefficient values of sulphamidine and acetylsulphamidine present in water/octanol solution at different pH.
Abstract: After measuring the pH of the buffer solution, two lots of eight bottles were prepared. 5ml of drug and 5 ml of buffer solution were added to each bottle and shaken for 30 minutes. Absorbance was then of the solutions in the bottles was then determined. Introduction: Partition coefficient gives a measure of how a substance distributes in two different phase at equilibrium. Partition coefficient is utile in estimating the distribution of the drug within the body. There are two types ...
