Abstract
IFITM3, a protein induced by interferon, restricts reovirus infection in host cells and inhibits the viral replication. It affects the proper penetration of the virus by altering the dynamics of the viral uncoating in the endosomes. This study is the first in characterizing the anti-viral activity of IFITM3 on non enveloped viruses that depend on endosome for cellular entry. Following contagion with a virus, the body triggers the release of a class of cytokines, interferons that are involved in first line of defense against infection. Type I interferons are specifically induced in the cells following insult with both DNA and RNA ...
