First, when looking at labile cells, it can be said that ultimately these are continuously dividing cells of short life span, which directly pass from M to G1 phase of the cell cycle (Abuhashim). The surface epithelium of gastrointestinal and genito-urinary system, epidermis of the skin, and hemopoietic cells of the bone marrow are placement examples of labile cells. “Injury of these cells is followed by complete regeneration providing that the supporting stroma is intact” (Abuhashim).
Second, when looking at stable cells, it is understood that these tiny units are subjected to very scant postnatal divisions yet they are competent of division after injury or when activated. Stabile cells pass from Go to G1 (Abuhashim). They include renal tubular cells, hepatocytes, mesenchymal cells; such as, glandular cells, smooth muscle, cartilage cells, osteoblasts, endothelium and connective tissue cells. “Injury of these cells is followed by complete regeneration if the supporting framework is preserved” (Abuhashim).
Lastly, it is Permanent cells which are found in the central nervous system and heart. They cannot be regenerated once they are destroyed. If and when the framework is demolished, fibrosis conducts repairs. “These particular cells have abandoned the cell cycle and absolutely cannot undertake mitotic division in postnatal life. Injury of permanent cells will always heal by fibrosis and if in the brain, it heals by gliosis” (Abuhashim). The primary intention of wound healing comes by the usual surgical wound, where there is a sterile wound with “well-apposed
edges, and minimal clot formation”. The Secondary intentions prevail when “wound edges cannot be opposed, usually infected with debris and blood clots” such as crush injuries and those which result in a large scar (Abuhashim).
Finally, when comparing benign tumors to that of malignant tumors, primarily it can be said that benign tumors are not cancerous whereas malignant tumors are cancerous and are composed of cells in which grow out of control. Some of the most common types of benign tumors include Meningiomas, Adenomas, Fibromas or fibroids, Lipomas (PCA). The two most common types of malignant tumors include Sarcomas and Carcinomas. It is very important to understand that all tumors share irrefutable characteristics, one being that they are the culmination of cells within one’s body that are no longer needed or are indeed very old or damaged cells which were not destroyed at an earlier period in which they should have been (PCA).
On another note it is very important to understand that benign tumors can often be removed from one’s body and generally do not have a custom of coming back in most cases. Furthermore, the cells in benign tumours do not spread to other parts of the body (PCA). However, on the contrary malignant tumors containing cells in which are known to invade the nearby tissues of the body and spread to alternate parts. It is quite frequent on occasion for these particular cells to progress themselves away from the “primary cancer site” as they spread to alternate organs and bones (PCA).
It is here in these alternative areas in which the malignant cells administer self-grow and often form other tumours within this particular site (PCA). This result is distinguished as secondary cancer (metastasis).
Abuhashim, Maha M., Dr. “Repair, Regeneration, and Fibrosis”. PDF, 19 Feb. 2014. Web. 5 Feb. 2016.
PCA. “What Is the Difference between a Benign and Malignant Tumour?”. Pancreatic Cancer Action." Pancreatic Cancer Action ICal. 2016. Web. 05 Feb. 2016.