Roseola also known as exanthema subitum or Sixth disease is a viral infection caused by human herpesvirus 6 (HHV-6) common in infants and young children. The pathognomonic sign of roseola infantum is the development of acute high fever and febrile seizure. Commonly after defervescence, a rubelliform eruption or rash occurs. A clinical exam is needed to diagnose roseola and the treatment is symptomatic (Caserta, 2014). To patients who are immunosuppressed, HHV-6 is a major cause of morbidity and mortality. HHV-6B can also cause CNS disease in these immunocompromised patients ("Roseola Infantum", 2016).
Pathophysiology
The transmission of the HHV-6 is airborne, ...
