Rat Endocrinology
Hypothalamus 1. What is the molecular mechanism to release TRH? TRH refers to the thyrotropin-releasing hormone. This hormone is produced by the hypothalamus. Before the full activity of TRH, some tightly controlled processes occur in the body including the appropriate folding of prohormone to move to the secretary pathway, the processing after translation, and movement of the peptides, which are processed, towards the secretary granules for secretion (Nillni n.p.). TRH develops from bigger inactive precursor (known as proTRH) as a result of modifications after translation and moved through the controlled secretary pathway. Prohormone convertases (abbreviated as PCs) including PC1/3 ...
