Essays on Elston

Genetic Correlates and Pathophysiology of Hyperthyroidism: An Overview of salient aspects

Introduction Disturbances in thyroid haemostasis can occur at the level of the pituitary gland, the thyroid gland itself or in the periphery. By definition, hyperthyroidism refers to disorders in which the principal abnormality is the overproduction of thyroid hormones in the thyroid gland. (Elston & Conaglen, 2005) This overproduction can have diverse determinants including auto-immunity, hereditary factors, familial predisposition, and perhaps, some other less understood factors. Regardless of etiology, the result is an increase in transcription in cellular proteins, causing an increase in the basal metabolic rate. The predominant cause of hyperthyroidism is Grave’s disease. Other less common ...

The complexity of managing hyperthyroidism is largely attributable to the multi systemic effects, a diverse range of symptoms and a wide clinical spectrum ranging from subclinical to severe disease. This work briefly touches on the trends in management of hyperthyroidism and key research findings that have guided clinical approaches over the last 2 decades. Literature review highlighted some niche areas that have predominantly been the focus of research. These include, evaluation of diagnostic criteria, interpretation of laboratory results and prognostic implications of subclinical thyroid disease.

Diagnostics

Thorough clinical assessment of patients continues to be indispensible with serum TSH level being the standard ...

As the top health administrator for Well Care Hospital in Happy Town, USA, I place a great deal of importance on professional conduct within my particular health care setting. Because of the often life-and-death ramifications of the actions of health care professionals in all aspects of the profession, it is doubly important that these officials operate at the highest standards of ethics and professionalism. Allowing hospital misconduct to flourish under my administration would reflect poorly on myself as well as the rest of the staff, and diminish patient confidence and faith in our ability to do our jobs. Consequently, maintaining ...

Carter, Jimmy. Keeping Faith: Memoirs of a President. New York: Bantam Books, 1982. Jimmy Carter’s term as the U.S. President was essentially a time between two reigns, a bridge and carried the country from the end if its concern with Watergate scandal to the advent of Reagan revolution (Elston 3). Carter arrived in Washing from Georgia in 1977 as an outsider who conformed to the political odds to secure an elective position in the first place. He left office after four years, still largely an outsider, after a shocking electoral defeat in which he lost 44 out of 50 states. Keeping ...