1.0 Introduction Hemophilia A (HA) is an inherited X-linked bleeding disorder that results from a wide range of mutations in the factor VIII (FVIII) gene which leads to the absence or quantitative and/or qualitative deficiency of the said blood clotting factor ( (Jacquemin, et al., 2000; Guillet, et al., 2006; Venceslá, et al., 2008). FVIII gene is one of the most extensively investigated of all human genes and these extensive studies have led to the identification of a wide range of different types of mutations responsible for HA. Some of the mutation types identified include point mutations (resulting in missense, nonsense ...
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