Essays on Thrombin

Status of the document.

This document is a project proposal for the development of starch-based hemostatic products. Acknowledgement. Much thanks to the project supervisor who offered guidance in every step of the development of this proposal. Developing starch based hemostatic products Project summary. Purpose: This proposal is envisioned to develop a hemostatic agent from purified plant starch. In this case, the product of the reaction should be developed by the formation of microporous hemosphere particles after etherification, esterification and crosslinking of glucose molecules to form ethyl propanetriol (glycerol-ether links (1-3 deoxy propanol)). The second intention of this study is to investigate the properties ...

Novel drug sourced from snake venom

Abstract The cardiovascular and cerebrovascular diseases have continued to be some of the leading death causes across the globe. In the recent times, the field of medicine has received substantial advancements, particularly in the areas of pharmacological treatment and the prevention of the disorders such as the plasminogen activators, platelets GPIIb/IIIa antagonists and the direct thrombin inhibitors. The development of the novel drug, the tirofiban sourced from the Echis carinatus venom been highly reported to be of great importance. Tirofiban, an anticoagulant factors isolated from Echis carinatus has a variety of immune responses that includes both acute inflammatory responses ...

Abstract

Factor V Leiden is a genetic mutation that confers resistance to the action of activated protein C and thus predisposes to venous thromboembolism. It’s inherited as an autosomal dominant trait and is prevalent amongst Caucasians with a carrier rate of 4%. Deep venous thrombosis and pulmonary embolism are the most common clinical manifestations of FVL related VTE although it can also affect other sites. Genetic testing for FVL is used for diagnostic as well as predictive purposes. Diagnosis of FVL is based on protein assays and

DNA analysis technology. Familial genetic testing for FVL is generally not recommended except in ...