Essays on Ca2

1. Biot’s respiration named after Camille Biot is an abnormal ataxic breathing pattern, where rapid series of shallow respiration are followed by a period of apnea. In order to known how AMP kinase, knock down leads to Biot respiration in mice; it is necessary to known how AMP kinase affects respiratory rate. AMP kinase is a metabolic sensor and is activated in response to stretching of the lung alveolar cells and other stressors. During respiration, the lung goes through cycles of expansion and contraction (Budinger et al., 2008). When the alveolar cells stretch during expansion, the 5′ AMP-activated ...

The function of golli-MBP is less understood than that of the classic MBP. However, golli-MBP is believed to play an important role in various physiological activities such as the regulation of calcium (Ca) homeostasis especially in oligodendrocytes (OLs) and in T-cells ( Paez et al., 2007). The latter authors investigated this particular property of golli-MBP using fluorescent protein clones, cell lines and imaging techniques. It was revealed that when overexpressed in OL cell lines (N19), the golli proteins activate the elaboration of processes and sheets which retract rapidly following a depolarization with high potassium ions (K+). Simultaneously, a substantial augmentation ...

Muscle contraction is a very important activity that enables an organism perform various bodily movements and flexible actions, in response to nerve stimuli. Muscle fibers are multinucleated long cylindrical cells that have an outer membrane called sarcolemma, and are mainly composed of contractile elements called myofibrils (Dougherty, 2016). Myofibrils are made up of repeating units called sarcomeres. Sarcomeres in turn are composed of (thin) actin and (thick) myosin protein filaments called myofilaments (Dougherty, 2016). The muscle fiber structure and organization is shown in Fig 1.

Contraction Mechanism – Sliding Filament Theory

According to the sliding filament theory, during contraction myosin filaments remain constant in length, ...

Introduction

The total number of patients with cancer keeps soaring globally with around 14 million cases diagnosed by 2014. Each year, about 8 million people die of cancer-related illnesses globally. There are quite some remedies that have been proposed to mitigate in the cancer menace. This study is focused on cancer treatment by curcumin through tyrosine kinase inhibition. Curcumin is the primary coloring agent found in turmeric, a tuber of the herb Curcuma longa Lin. It has widespread use as a flavoring agent (Aggarwal and Bokyung 87). It is also well known for its medicinal value commonly used to suppress ...