The function of golli-MBP is less understood than that of the classic MBP. However, golli-MBP is believed to play an important role in various physiological activities such as the regulation of calcium (Ca) homeostasis especially in oligodendrocytes (OLs) and in T-cells ( Paez et al., 2007). The latter authors investigated this particular property of golli-MBP using fluorescent protein clones, cell lines and imaging techniques. It was revealed that when overexpressed in OL cell lines (N19), the golli proteins activate the elaboration of processes and sheets which retract rapidly following a depolarization with high potassium ions (K+). Simultaneously, a substantial augmentation ...
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I. Introduction Advances in recombinant DNA technology and bioinformatics-based data analysis have driven the explosion of structural biology in the last two decades (Kelly, Jess, and Price 119). This has resulted to the identification of at least 2000 proteins annually and a growing need in performing structural studies in these new proteins. The current trend involves the concern of analyzing protein structures close to its natural conditions (and other conditions) and of measuring their rates of structural changes, an essential factor in their biological functions. The technique of circular dichroism (CD) has gained an increasing popularity in addressing these ...
1.0 Introduction
Multiple sclerosis (MS) is a neural degenerative condition involving the progressive degeneration of the myelin sheath (the protecting cover to the nerve fibres (axons)) around the nerve cell leading to a break down in transmission of nerve impulses. The impairment of the transmission results in loss of the body’s ability to control and coordinate muscle movement. The disease progresses through a complex and diverse symptoms making it challenging to diagnose, treat and manage. The symptoms of MS may range from gentle to severe weakness, impaired body movement, lack of ordered senses, uncontrolled bowel and bladder, damaged cognition, impaired vision and a variety ...
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Multiple sclerosis (MS) is a neural degenerative condition involving the progressive degeneration of the myelin sheath (the protecting cover to the nerve fibres (axons)) around the nerve cell leading to a break down in transmission of nerve impulses. The impairment of the transmission results in loss of the body’s ability to control and coordinate muscle movement. The disease progresses through a complex and diverse symptoms making it challenging to diagnose, treat and manage. The symptoms of MS may range from gentle to severe weakness, impaired body movement, lack of ordered senses, uncontrolled bowel and bladder, damaged cognition, impaired vision and a variety ...
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