Essays on Liver Transplantation

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Introduction Cirrhosis is caused by liver injury that results in fibrogenesis and inflammation. These problems result in collapse of liver structures and significant distortion of hepatic vascular structure. This distortion leads to elevated resistance to portal blood flow as well as portal hypertension. Moreover, hepatic synthetic dysfunction is also caused as a result of these problems. Clinically, liver cirrhosis is considered as an end-stage disease that could result in death until liver transplantation is performed (Tsochatzis, Bosch, & Burroughs, 2014). Liver cirrhosis is an important cause of morbidity and mortality in most of the developed countries. In ...

Abstract

In the following case-study, Joshua is a newborn infant presented by his parents Samuel and Rachel to the pediatric outpatient unit of Robertsbridge, Sussex for screening and medical advice for sporadic vomiting at the time of breast feeding and seizure-like episodes. Samuel and Racheal also report sweet odor in the urine and loss of weight. Blood tests demonstrated increased concentrations of leucine and isoleucine. Genetic testing on the skin biopsies reveal mutation at Exon 6, c.659C>T of the of BCKDHA gene with a protein level p. A220V and Joshua exhibits about 1.5 % lesser than normal deficiency in the ...

- Scope and purpose The guideline under study is “Neurological problems in liver transplantation”, developed by Guarino et al. (2011). The guideline is dedicated to creating recommendations on preventing and combating several neurological problems that occur after orthopic and cadaveric liver transplantation. The six key conditions in medical practice include immunosuppresion neurotoxicity, seizures, central pontine myelinosys (CPM), neuromuscular disorders, cerebrovascular disorders and central nervous system (CNS) infections (Guarino et al., 2011, p.491). The body of the study consists of six subsections. Each of the subsections contains basic information about the conditions under study and recommendations that can be ...