Essays on Natl

Vid30 complex participation in the degradation of CDC25 in yeast and their role in Ras/ cAMP/ PKA pathway

Background: Unicellular organisms such as Saccharomyces cerevisiae in its total life cycle is exposed to diverse and changing nutrient conditions. Thus, in order to survive and achieve a competitive advantage, it has adapted itself such that it not only uses the wide range of available nutrient sources but also the sources that are nutrient rich. It mainly uses fructose and glucose by rapidly fermenting to alcohol. In response to these nutrient conditions, the intracellular trafficking transcription and turnover of protein from nutrient transporters (e.g. Hxts) get regulated. Therefore, when the availability of the glucose increases, the expression of low- ...

Introduction

Studies relating to lung cancer treatment can save lives and make the lives of cancer patients more comfortable besides increasing the quality of life. According to Lardinois et al., (2003), there are three primary types of lung cancer; they include non-small cell, small cell, and carcinoid lung cancer. Statistically, non-small cell lung cancer, for example, Squamous cell carcinoma, adenocarcinoma, and large cell carcinoma account for the highest occurrences of all lung cancers to a tune of 85% [1]. It has been established that both environmental and genetic factors do contribute to lung cancer significantly. Continued exposure to carcinogens, ionizing ...

Introduction

Recently, worldwide obesity prevalence has been raised rapidly and nearly doubled between 1980 and 2014, however in 2014 more than a half a billion of adult (18 years and older) were obese (11% men and 15% women) (WHO, 2014). Obesity and overweight are defined as excess body fat accumulation that leads to health risks and comorbidities. Adult weight can be classified based on the Body Mass Index. Hence, an individual having a BMI equal to or more than 25 is regarded as being overweight, while a person with a BMI equal to or more than 30 is considered obese ( ...