Essays on Pharmaceutical Sciences

Scientific research is categorized into basic research and applied research and development. The main objective of basic research is to advance knowledge especially in universities with its results being published in books or journals. Applied research, on the other hand, focuses on creating new products with applications in industries where new formulations are done. Applied research also involves coming up with trade patents and trade secrets. In contrast, whereas basic research is funded by the government, investors and the private sector fund applied research. In coming up with new products, activities beyond the confines of research take place including, ...

Hansch Analysis

Hansch analysis is used widely in the field of medicinal chemistry. It is the analysis that investigates the quantitative relationship and correlation between the compound’s biological activities with their physicochemical substituents. The global parameters considered in this method include the electronic, steric, hydrophobic, and other effects that use multiple correlation methodology (IUPAC). Application of the Hansch analysis includes the Quantitative Structure-Activity Relationship (QSAR). This application develops correlations between activity of the ligands and their properties. As a rule of the thumb, the Hansch model “gives information about the number of parameters to be selected for regression analysis in ...