Regulation Of Gene Expression Essay Examples - Only The Best to Spark Your Inspiration!

Introduction

Hypothyroidism is a condition mainly characterized by low concentration of serum T4 (thyroxine) hormone. When this happen during pregnancy is known as maternal hypothyroxinemia. Adequate Thyroid hormone (T4) levels are critical during first trimester of gestation when the only source of T4 hormone of the fetus comes from the mother. A deficiency of T4 hormone constitutes a risk factor in the neurodevelopment and growth of the fetus . Severe mental retardation is one of the major conditions observed in children with non sufficient levels of thyroxine (T4) hormone during early fetal developing stages. It is now well documented, that thyroid hormone ...

a) Background and Significance Type 2 Diabetes Mellitus is a chronic disorder characterized by two main features: high blood glucose level (hyperglycemia) and insulin resistance. The disorder was formerly referred to as non-insulin-dependent diabetes mellitus. The pathophysiology of type 2diabetes is progressive, characterized by decreased insulin sensitivity, deteriorating cell function, and decreased incretion function (Phielix and Mensink, 2008; Misra, 2008). In human studies, people with type 2 diabetes have a decreased PGC-1α expression compared to healthy subjects (Wagner et al., 2008; Cantó and Auwerx, 2009; Kang, 2012). The skeletal muscles of people with type 2 diabetes and those of their ...