Abstract
It has been observed that cAC10 , a monoclonal antibody that is chimeric, has the capacity to cause the in vitro arrest of the growing of the CD30+ cell lines in severe combined immunodeficiency (SCID)in models of mice having Hodgkin disease (Chiarle et al. , 1999; Weiner and Adams, 2000 ). Thus, it can `be said that these antibodies have antitumor activity.
Introduction
The potency of CD30 +-targeted mAb activity was increased by generating an drug and antibody conjugate, “cAC10-vcMMAE”. MMAE is a synthetic analog of dolastatin 10. “cAC10-vcMMAE” has potent cytotoxic activity against CD30 expressing cell lines and has exhibited stability in physiological ...
