Essays on Dose

- Introduction Radiations such as  - rays, UV rays, etc. have ionizing effects on tissues and have the ability kill cells and inactivate viruses. A detailed analysis of the survival of such cells and viruses are imperative in many fields, including radiation oncology, public health and environmental photobiology. However, the mathematical and statistical tools based on target theory in radiobiology are mentioned in literature (Alpen, 1988, Smith, 1989, Hall, 2000) and are wide in use in the analysis of experimental data involving biophysical mechanisms of the repair of radiation damage. This work demonstrates the use of probabilistic approaches ...

Radiologists and the complementary professionals and para-professionals face unique risks while at the work place. Exposure to ionizing radiation induces nuclear changes in cells that may cumulatively lead to cancer. In the case of the patient, the exposure to radiation is necessary in order to establish diagnosis or treatment and the benefits should outweigh the potential harm. For the staff on the other hand exposure to increased levels of exposure is hazardous and undesirable. Shielding is used to avoid accidental exposure to radiation, as well as careful obedience to the laws of physics. The effects of radiation lessen as ...

Glade Bender JL, Lee A, Reid JM, Baruchel S, Roberts T, Voss SD, Wu B, Ahern CH, Ingle AM, Harris P, Weigel BJ, Blaney SM. Phase I pharmacokinetic and pharmacodynamic study of pazopanib in children with soft tissue sarcoma and other refractory solid tumors: a children's oncology group phase I consortium report. J Clin Oncol. 2013 Aug 20;31(24):3034-43.

This study describes a phase I clinical trial of “Pazopanib” in pediatric patients suffering from soft tissue sarcoma (STS). Pazonapib is an anti-angiogenic drug. It is a competitive inhibitor of ATP molecule1,2. It competes with the ‘substrate’ ...

According to Lexus.us, Dosimetry is defined as “Measurement of radiation exposure, especially X-rays or gamma rays; calculation of radiation dose from internally administered radionuclides”. (2010). Neutron dosimetry is neither as precise nor as complex as gamma dosimetry. In the United States today, neutron dosimetry is among the vital requirements used to carry out comparison of the clinical results gotten from radiotherapy trials done at the fast neutron therapy facilities. The neutron dosimetry radiation uses specialized devices which includes superheated drop detectors. Gamma rays originating from the surroundings, the phantom or biological object experiencing the radiation, the collimating or ...

1. State how this adverse event could have been prevented. Adherence to protocols, policies and standards regarding medication administration prevents medication errors (Breeding et al., 2013). Prior to administering any medication, the six rights of medication administration must be fulfilled: right drug, right dose, right route, right time, right patient and right documentation. Upon procurement of the medication, drug label information must be compared with the prescription on the chart to ensure that they match. Visual comparison prevents errors from drugs that sound and look the same. To avoid confusion, studies show that it is best to check ...

Abstract

The research paper discusses the origin and nature of methadone, including the historical aspect of its development and further commercial and scientific use. The paper also describes the pharmacology of methadone, including the route of administration of the drug, its metabolism and its mechanism of action. Next section of the paper explains the experience in medical use of methadone, as it`s a great alternative to the painkillers based on the opiates, it plays a major role in the therapy of maintaining and replacement and treating the withdrawals syndromes. The positive effects on the pregnant patients are also described here with a ...

- Normal issues and Organ at Risk Due to Irradiation The radiation effects in human are due to the deposition of energy in the human body. Not all the tissues are exposed to the radiation effect. Only few of the tissues are exposed to the radiation effect. The radiation therapy is used for the medical treatment. A high dose of radiation will result in damage of sensitive tissue, even, it may result in death. A high dose of radiation results in the death of cells. All the cells are not equal to the radiation sensitivity. Only the sensitive ...

http://www.nlm.nih.gov/medlineplus/ 2. http://www.blackmores.com.au/products/joint-formula-with-glucosamine-chondroitin http://www.naturesway.com/ 3. Interaction between health supplements and prescription medication

Part A is answered for interaction between various agents

Fish oil and aspirin A clinical study was carried on 10 healthy patients to investigate the effect of omega 3 fatty acid prescription in combination with aspirin on the platelet aggregation effect and bleeding time. Aspirin alone inhibited platelet aggregation in presence of low concentration of collagen.Omega3 fatty acid treatment did not inhibit platelet aggregation under the experimental condition; however combination of aspirin and omega 3 fatty acid inhibited blood platelet aggregation. This study demonstrated the efficacy of prescribing omega-3 fatty acid (fish ...

Article Review Report

Kornmann O, Dahl R, Centanni S, Dogra A, Owen R, Lassen C, Kramer B. Once-daily indacaterol versus twice-daily salmeterol for COPD: a placebo-controlled comparison. European Respiratory Journal 2011; 37(2):273-279.

Why are you looking at this journal?

The European Respiratory Journal is a credible source of information because it is peer-reviewed. It is an official publication of the European Respiratory Society. My interest in the journal lies in the focus of the articles it publishes. The journal publishes experimental and clinical work on all aspects of respiratory medicine including the biology of lung cells, pathophysiology, epidemiology, immunology, thoracic imaging, thoracic surgery, occupational medicine, pediatric pneumology, intensive care, ...

Introduction

Objective The effect of gamma radiation exposure on various biological species is known to vary with the radiation dose. Contrary to earlier theories which predict greater damage with increasing dosage, recent studies have observed a non-linear relationship at relatively low doses (Al-Safadi & Simon, 1996; Bajaj et al., 1970; Mokobia, & Anomohanran, 2005). An experiment to observe this effect on the monocot crop plant Hordeum Vulgare was carried out. Varying doses of 0 Krad, 5Krad, 10 Krad, 25 Krad, 50 Krad, and 100 Krad were used on six batches of seedlings. The aim of this paper is to discuss the methodology ...

Analysis of NSAIDs non-selective take (Ibuprofen and Naproxen)

Health impact of many diseases leaves a potential consequence on the quality of life (QOL). The frequency at which such impact occurs could vary from one disease condition to the other. Affected individuals need to encounter physical and psychological distress. However, scientific advancements have made a progress in alleviating such problems. Especially, pharmaceutical science has become a reliable branch to cater the needs of people who suffer from illnesses. Understanding the efficacy and other properties of various drugs is important for the better therapeutic application of pharmacy. In such context, the present description deals with highlighting about Analysis of NSAID take by ...

The study aimed to offer description on the use, as well as the effect resulting from low-dose ketamine or LDK for the analgesia cases in the emergency department (ED). The study used a retrospective mode of data collection where information on patients who received LDK for analgesia were used to describe the effectiveness and safety of the drug. The study used those patients who were aged 18 years and above and were given ketamine in the ED within a period of two years when the study was conducted. Parameters such as dose, route used to administer the drug, as well as ...

Some tricycle anti-depressants have been successfully used to lessen the problems associated with depression. This paper addresses information available about Clozapine (a tricyclic dibenzodiazepine), Protriptyline (a dibenzocycloheptene derivative), and Clomipramine (a dibenzazepine). Tricyclic antidepressants work by inhibiting the reuptake of norepinephrine and serotonin into nerve terminals. Clomipramine is prescribed to control obsessional behaviour (an antiobsessional drug); it is a very strong drug which must be used with care. The strong sedative properties of Clomipramine require careful observation of patients during the treatment. It was found the Clozapine is commonly taken by oral dosage to lessen effects of depression. Protriptyline which was marketed as Vivactil® has ...

Antifungal Medications

In dentistry and oral care medicine, antifungal medications are prescribed less compared to conventional analgesic or antibiotics. However, it is mandatory that a clinician or dentist is familiar with common antifungal indications and medications available in the market. Antifungals are used to treat oral candidiasis. Oral candidiasis is known to cause complex oral health problems. Oral and pharyngeal candidiasis is caused by the primary fungal organism Candida albicans. Oral candidiasis is listed as an acquired immunodeficiency syndrome by the Centers for Disease Control and Prevention. Due to imbalances in the oral flora, patients using oral antibiotics could develop case of ...

Introduction:

- The impact of medication/dosage calculation

Position: Nursing faculty improves student performance with medication/dosage calculation

Body: Relevant information - importance of medication and dosage calculation - types of calculations - A clear connection between nursing faculty and medication/ dosage calculation

Conclusion

- Summary - Recommendation based on the reviewed literature.

References

The sources used included at the end of this paper Introduction Dosage calculation is the computation of the amount of medication to be administered in a required dose, strength and unit volume. Calculations are significant sources of medication errors (Cowan, 2009). The patient safety depends on the practitioner ability to calculate dosage accurately and ...

Introduction

Nebulization is the most effective method for delivering medications to patients suffering from respiratory disease. Nebulizers do not require special inhalation techniques; therefore, hospitals utilize a variety of nebulizer designs for medicinal delivery. One of these devices is called AeroEclipse, which can be operated via one of two different modes. The breath actuation mode generates aerosol only during the patient’s inspiration while the other mode allows for the continuous generation of aerosol particles regardless of the patient’s inspiratory and expiratory efforts. Also, the AeroEclipse has two different patient interfaces: the facemask and the mouthpiece. The hypothesis of this ...

Abstract

The use of influenza vaccine has both advantages and disadvantages. Its low efficacy rate has resulted to several questions being raised on whether it is necessary to have the vaccine. This paper aims to discuss whether it is beneficial to obtain influenza vaccine in terms of its safety and effectiveness. The topic will also go beyond science by focusing on the cost effectiveness of the influenza vaccine. The study was done by looking for other peer-reviewed sources and doing an assessment of the information presented. The studies have shown several benefits of using influenza vaccine such as efficacy, safety ...

Management of the Postsurgical CABG Patient

Management of the Postsurgical CABG Patient Coronary artery bypass graft (CABG) surgery is a recommended treatment for coronary heart disease (CHD). In the United Kingdom, around 2.7 million people have been diagnosed with this condition (NHS, 2012). The aim of surgery is to relieve angina and shortness of breath by improving the flow of blood to the heart (Parry et al., 2010). These symptoms cause severe discomfort and distress as well as limit the amount and type of physical activity a patient may engage in. Surgery helps patients attain a higher quality of life referred to as satisfaction with life ...

Introduction

It is generally noted that the development of dosimeters to measure neutron exposures has been slow for many years in comparison to the development of gamma and x-ray dosimeters. Exposures to x-rays and gamma rays have been determined from glass dosimeters and film badges. By applying these dosimeters, personnel exposure to radiations caused by radioactive substances can be measured to standard accuracy. However, the uncertainty may arise due to variation in readings as a result of orientation of the wearer of the dosimeter to the source during exposure. On the other hand, NTA film has been the only neutron dosimeter ...

Warfarin as used in medicine

Warfarin is a drug that serves as an anticoagulant; it is most commonly used in the medical field to prevent thrombosis which is the formation of blood clots and thromboembolism which is the migration of these clots to other parts of the body. It is also used in the management of deep vein thrombosis, arterial fibriation and pulmonary embolism.[1] This drug is a derivative of dicoumarol a 4-hydroxycoumarin-derived mycotoxin anticoagulant that was discovered in spoiled animal feeds that are made using sweet clover.[2] The recommended dosage is 10mg of warfarin for urgent anticoagulation, after that a maintenance dosage of 5mg ...

Background

Asthma is a chronic disease associated with inflammation of the lining of airway and obstruction of lung airflow. It usually involves an increase in the number of inflammatory cells, most commonly eosinophils and to some extent basophils, mast cells, macrophages. (Eds. Brunton, et al., 2009) Asthma, together with Chronic Obstructive Pulmonary Disease (COPD), is considered as one ofthe most common obstructive lung diseases characterized by expiratory airflow obstruction. (eds. Longo, et al., 2012) An asthmatic patient usually presents with recurrent events of shortness of bright (SOB), chest tightness, and wheezing, “a high-pitched whistling sound when breathing caused by movement of ...

Lorazepam

Introduction Depression of the central nervous system (CNS) has been a vital technical know-how in the cure of anxiety, increase of sedation, decrease in tension, and curing of insomnia through enhancement of sleep. Similarly, depression of the CNS is believed to produce a continuum effect in the generation of anesthesia and loss of consciousness, which aid in alleviating anxiety (Aschenbrenner &Venable, 2009). In light with this, there are a variety of effects associated with the depression of the CNS, and they are largely attributed to the drugs used as a depressant. Dosage and the route of administration are the core determinants in ...

ABSTRACT

This article aims at illustrating the two types and effects of the cancer treatment techniques. Several methods are discussed and analyzed by defining them and showing their impacts on the patient. The article goes further to compare and contrasts the various methods that have been put in practice to treat cancer in an effort to determine the best. Radiotherapy alone, radiotherapy with chemotherapy, 3D CRT and IMRT are some of the discussed techniques in the article. Data was collected among the cancer sick patients who underwent different treatments. The patients were put under different conditions in regard to treatment ...

Introduction

Aspirin is one of the most commonly used drug in the world. The generic name is acetyl salicylic acid and the drug belongs to the group of non- steroidal anti-inflammatory medicines, which works by inhibiting the production of compounds in the body that cause pain, fever, inflammation, and blood clots (Koester, 1993). Aspirin is also a member of the salicylate family of compounds as it is synthesized from salicylic acid, which was discovered in Oxford (UK) by Edward stone in 1793 and first synthesized in the laboratory in 1897 by a German scientist, Felix Hoffmann of the Bayer company (Rinsema, 1999). ...

Problem Statement

Most medical scientist and psychiatrists have defined depression as a mood disorder that often results to incessant feeling of extreme sadness and loss of interest in most activities that one used to enjoy. Depression has various references; the condition could be referred to as major depression, major depression disorder or clinical depression. Depression results to a variety of emotional and physical problems because the condition affects one’s thinking and behavior. Depressed people find difficulty in doing everyday tasks and experience severe hopelessness. Depression affects 19 million adult Americans, meaning it is the leading mental disorder in the U.S. Studies ...

~200 keV Radiation Field Appropriate research problems and proposal: Could scientists create a radiation detector that can measure all forms radiation energy with the same accuracy over a wide energy range, and if they cannot, what technological progress has taken place today that may improve the radiation detection procedures and equipment is used. Arguably, radiation detectors and dosimeters are important tools to evaluate radiation exposure and ensure a safe work area. However, no single detector can measure all forms of radiation level with similar accuracy and efficiency yet there are different types of particles that produce radiation. As a result, different ...

Prevention is crucial when it comes to combating rabies. Luckily, it is also quite easy. Prevention is classified into two methods: primary and secondary. Primary prevention: minimizing and avoiding exposure: One of the most vital steps in checking rabies is educating the endangered about sensible pet ownership as well as how they can avoid or minimize their rabies exposure. To begin with, dogs, cats and other pets must receive regular rabies vaccines. The conventional rabies vaccine was initially administered to dogs once annually, but desires to reduce vaccine frequency initiated the development of rabies vaccine that is now ...

Introduction

Emergence of image guidance technology Today’s computer-aided healthcare technology relies on much modality medical image and multimedia information. An image-guided radiation therapy was introduced due to the ever-increasing challenges originating from fast growth of the information technology sector and the global expansion of healthcare needs. Image guided technologies aid in the effective management of patients in the areas of detection, diagnosis and intervention. The image guidance technologies is a process that uses frequent imaging during a radiation therapy in order to improve accuracy and precision in delivering of treatment (Peters & Cleary 2008). Before the introduction of image guidance technology, ...

WHI Trial (Writing Group for the WHI Investigators; JAMA)

What was the main objective of the WHI study? Assesment of the most commonly used combined hormone preparation in the US for health benefits and risks When and why was the subject enrollmentstopped early (specific statistical reason)? After 5.2 years. This was due to harm from the breast cancer.

What was the design of the trial?

16608 postmenopausal women underwent the study over 8.5 years

Who monitored the “double-blind” data? How often?

Safety monitoring board.Monitored semiannually.

How many women: screened, randomized, assigned to either arm?

373092 – Screened, 16606 – Randomized, 8506 – Estrogen, 8102- Placebo Why was the dose of E 0.625 mg/day and P 2.5 mg/day in a single tablet chosen?

Highest amount without damaging the subjects

Why was an “intact uterus” necessary for entry ...

Introduction

The information provided by pharmacokinetics is important in the discovery of new drugs and in screening drug candidates. It helps in drug research and can determine the concentration of a drug present in the body. The discovery of new medicines not only depends on pharmacological activity but on pharmacokinetic parameters as well. Pharmacokinetics includes absorption, distribution, metabolism and execration (ADME). Absorption is the absorbing of a drug in the blood stream. There are two types of absorption, passive and active. The physico-chemical properties are responsible for passive transportation while the active transportation determines the binding of a molecule to the target site. ...

IN POST- MENOPAUSAL WOMEN

INTRODUCTION The purpose of the study is to analyze the relationship between vitamin D intake in the post menopausal women in the age group of 55-60 years and osteoporosis. The elderly women have higher chances of losing vitamin D and thus suffer from multiple fractures and falls. Vitamin D is a fat soluble vitamin that is stored in the fat cells of the body. It helps in the absorption of calcium by the body. Calcium and other minerals like phosphates are required for maintaining bone health. Deficiency of Vitamin D leads to rickets in the young age and ...

LSD has been a popular approach among psychotherapists, as it has presented beneficial effects for patients, in treating anxiety. My query is regarding the efficacy and safety of LSD on patients while treating for psychological perspective. The required effective and suitable dosage of LSD is also a considerable question, that what amount of LSD exerts positive effects (Gasser et al 153; Hofmann 53-60). LSD or Lysergic acid diethylamide is a compound that was considered to play a significant role in serotonin neurotransmitter system. As a potent psychedelic, it has been associated with brain functioning. Various clinical trial based studies have revealed that it ...

Biology of Disease

Mode of action of;- Dexamethasone The Glucocorticoid receptors are discovered intracellularly in all tissues. They enter cells through inactive dispersion and structure a complex with a receptor protein (Rhodes & Hartnoll, 2002, P.10). This intricate then experiences an irreversible enactment and enters the cell core, where it ties to the DNA, hence prompting organic impacts instigated by these hormones, which include expanded hepatic gluconeogenesis, as well as expanded lipolysis (Ahmed, 2007, P.13). Dexamethasone is utilized to treat numerous provocative and immune system conditions, for example, rheumatoid joint pain and bronchospasm. Idiopathic thrombocytopenic purpura, an abatement in quantities of ...

Asthma is a chronic airway disease that is difficult to manage because of numerous risk factors and complicated by poor self-management. This is a case study of acute severe asthma triggered by viral respiratory infection and exercise in an Aboriginal female with chronic asthma. The discussion will include the diagnostic tests, patient assessment, care and interventions, medications, and nursing care performed or should have been performed. The expected outcomes will also be described.

An arterial blood gas (ABG) analysis was performed showing respiratory acidosis and mild hypoxaemia. Above normal PaCO2 and below normal pH meant the lungs could not eliminate carbon ...

Abstract

Patients put immense trust in the healthcare providers, and in return expect safety in their hands. Healthcare Informatics, and electronic health records in particular goes a long way in ensuring their safety. The EHR improves care through safer, more accurate and complete information being shared among all the healthcare providers. Wait times for appointments - procedures, and access to community care facilities - are reduced. So are for the laboratory test results and clinical diagnosis. The electronic systems also ensure enhanced security of health information through encryption. It also allows doctors access to secured patients’ information. These include patient physicals, ...

The aim of the research is to provide a solution to the problems that arise due to the high doses of radiation. Radiation is used in the treatment of diseases that involves the usage of high radiation therapies such as X-rays, CT scans, ultrasound scan and MRI scan. Major radio therapy techniques have led to adverse effects on patients due to the excess dosage of radiation. The research would help to reduce the harmful effects caused by the exposure to radiation by designing radiation protection programs that protect workers, patients and the environment. The newer X ray and CT scan ...

who have had an ischemic stroke

BACKGROUND

Prolonged lowering of a patient’s blood pressure after a stroke occurs has been observed to reduce the risk of recurrent stroke. Additionally, the inhibition of the renin-angiotensin system in with regard to high-risk patients has also managed to reduce the rate of subsequent cardio vascular events, which includes stroke related complications. However, the effect of lowering a patient’s blood pressure using a renin-angiotestin system inhibitor such as Telmisartan, soon after an ischemic stroke has occurred has not yet been clearly established. According to previous research studies and statistics retrieved from WHO, stroke has been ...

Introduction: Prior to the discovery of penicillin by Alexander Flemming millions of people worldwide succumbed to common infections. The influenza pandemic of 1918-1919 killed nearly 30 million people, which was higher than the population that succumbed to the First World War. Following the discovery of penicillin in 1928, a number of other antimicrobial agents were discovered from natural sources or synthesized in laboratories that led to treatment of many infectious diseases worldwide. It was believed at one point that these magic bullets could be used to target and kill any and all kinds of pathogenic microorganisms. However, soon after the ...

Introduction

Lysergic acid diethylamide or LSD refers to a semisynthetic psychedelic drug belonging to the ergoline family. The drug is well known for the psychological effect. These psychological effects include altered thinking, synesthesia, closed- and open-eye visuals, a changed sense of spiritual experiences, as well as time. The drug is used as a recreational drug, an entheogen, or as a psychedelic therapy agent. LSD is not known to cause addiction or damage to the brain and has a very low toxicity when compared to the dose administered (Lüscher and Ungless).

History

The first synthesis of LSD was conducted in 1938 by a Swiss chemist known as ...

The Metabolism of (PABA) Para-Amino benzoic Acid

Introduction PABA or Para amino benzoic acid is a non proteinous amino acid that occurs naturally. The molecular formula of para- amino benzoic acid is C7H7 NO2; the structure of PABA consists of benzene rings substituted with a carboxyl and an amino group. PABA is a white crystalline molecule that is only sparingly soluble in water. PABA is a very essential nutrient for bacteria PABA functions as an intermediate in the synthesis of folic acid in bacteria The deficiency of PABA does not cause any deficiency diseases in man. Some bacteria in the intestinal tract can synthesise PABA from chorismate. Humans ...

1. Which of the following is an antidote for benzodiazepine overdose or toxicity?a. Buspirone (BuSpar)b. Hydroxyzine (Visteril)c. Flumazenil (Romazicon)d. Naloxone (Narcan)There is one other drug overdose antidote in the above list. Name the drug and its mechanism of action. Flumazenil (Romazicon®) is another drug given to reverse the depressant effects of benzodiazepine and thus useful for overdose treatment. It acts as a competitive antagonist of benzodiazepines, having high affinity to GABAA receptors, which is the BZD binding site. This allows it to specifically target benzodiazepine and drugs with similar MOA such as zolpidem, but not other ...

Technical Fact Sheet

CHEMICAL CLASS/TYPE Morphine is an opiate alkaloid, which are a group of chemical compounds with analgesic (pain-relieving) and narcotic (sleep-inducing) properties. Similar compounds in its class include buprenorphine, and the synthetic opioid heroine. It is found naturally in the environment in the sap of the opium poppy plant, Papaver sominferum (National Center for Biotechnology Information, 2012). These compounds exert their actions on the body through the opioid receptors, which are found on many different tissues. Morphine has widespread effects in the body, of which the most prominent are on the central nervous system and on smooth muscle ( ...

A mother pleading her child to drink a glass of milk or an old woman inquiring about vitamin supplements is a common scenario that is observed in daily lives. It is not only the elders but also the nutritionists, doctors and the experts who are often emphasizing on the intake of leafy vegetables, citrus fruits, fish and the standard eight glasses of water. Such instructions are often associated with its underlying benefit which is explained by the presence of vitamins, calcium and other minerals. This makes the mind wonder as to why the intake of nutrients is incessantly stressed upon? The ...

Asthma Treatment

The research was undertaken to evaluate the safety and efficacy of three single doses of (R)-albuterol (levalbuterol) compared with a placebo and racemic albuterol in patients with asthma. Levalbuterol 1.25mg dose was used to compare with equal amounts of the R isomer in 2.50 mg standard dosage of racemic albuterol. Doses of 0.63 mg and 0.31 mg of Levalbuterol were also used in the study to represent one-half and one-third doses of (R)-albuterol 2.50 mg standard dose respectively

The research was double-blind, single dose ranging, five-way crossover study. The sample size was 20 patients with mild persistent to ...

Introduction

Definitely, infectious diseases refer to a wide range of disease infections that can be transmitted from infected individuals to healthier ones. Additionally, such diseases mostly spread due to unhygienic surroundings. Furthermore, the mentioned diseases can further spread from animals to people. Infectious diseases usually spread through a variety of ways inclusive but not limited to skin contact, blood contact, faecal matter as well as infectious discharges such as airborne droplets. Henceforth, this paper will explore on Tuberculosis as an example of infectious disease. Precisely, inflammatory responses by infected individuals will be explained. Moreover, mode of transmission, environmental predisposing factors, treatment and ...

Medication errors are estimated to cause approximately 7000 deaths annually and cost approximately $2 billion in added health care spending. Improving the safety outcomes of medication-use processes in hospitals has been cited as a means of addressing this issue. Careful and planned use of information technology is a proven approach to solve a majority of medication errors made with paper-based systems (Paoletti et al., 2007). These systems have been found to provide much better compliance with the “five rights” of medication administration: right patient, right dose, right route, right time, and right medication (Hook, 2008). Accordingly, the present paper describes a test ...

Neupogen is a granulocyte colony-stimulating factor that is in man-made form. The bacterium that is used in making this drug is Escherichia coli. Granulocyte colony-stimulating factor substance is produced by stimulation of the body cells. Neupogen drug has been widely used and has shown great effectiveness previously in patients suffering from cancer. It is preferred to people fighting cancer since it can stimulate the replication of the white blood cells in the body mostly referred to as the neutrophils. The benefit of the production of more blood cells among these patients is because the latter reduces their body’s’ vulnerability ...

Drug name: Lovenox is the trade name of Enoxaparin sodium. It is low molecular weight equivalent of heparin. Other trade names of this compound are Xaparin and Clexane. Dose and route of administration: Patients at risk of thromboembolic complications, from abdominal surgery, are given 40mg Lovenox per day. The drug is administered 2 hours prior to surgery, via subcutaneous route. For patients undergoing knee or hip displacement, Lovenox is given 12 hours prior to surgery, at the rate of 30mg, for thromboprophylaxis. The dose is continued for 7 to 10 days. For outpatients with deep vein emboli, Lovenox ...

DRUG DEVELOPMENT AND REGULATORY INTERACTIONS.An overview of drug interactions and activities in drugdevelopment. A drug is any component in the body other than food that is intended to affect the properfunctioning of human bodies or the animals. Drugs can be used in various ways including diagnosis, treatment, cure and prevention of diseases in humans and animals. Drug development refers to the continuum stages that are involved at each stage of development. The authorities have to be involved in the drug development process with a view of ensuring the safety of human. The drug must be taken through stages in its ...

Fall 2014

Assignment Questions - Identify TWO medications that the doctor might prescribe to you to help relieve the pain you complain of in your legs? Describe what each of these medications is prescribed for, the form they are available in, their side effects, possible adverse effects and the contraindications. You MUST choose medications that would be safe for you, the client to use (consider the current health issues). (8 marks) Pain medications help relieve pain and can have side-effects. Acetaminophen is an example of a common pain reliever. NSAIDs (Non-steroidal anti-inflammatory drugs) and narcotics are other types of pain ...

[Author]

Introduction

This literature review is intended to determine the effect of infection to the disability, mobility and psychological state of patients undergoing orthopedic surgery, comparing each in accordance to compliance or not of the surgical procedure to the Surgical Care Improvement Project (SCIP). Upon review however of the five available orthopedic surgical studies, there was no indication of any compliance or not to the SCIP protocol of the surgical procedures performed. The nearest mention of elements found in the protocol, such as anesthesia (SCIP-3) and postoperative blood glucose (SCIP-4) measurement, was found in Lin, Lin, Huang, Hsu, & Lin (2011). ...

Introduction

The Polio virus was first identified by Landsteiner and Popper in the year 1908 as an etiological agent for poliomyelitis. The polio virus was the first virus to be grown in cultured cells which was in itself a great breakthrough leading to (1) development of a killed virus and a live attenuated vaccine; (2) physical and chemical characterization of the virion along with its assembly intermediates, and (3) the characterization of the virus life cycle within the infected cell . Poliomyelitis is a highly infectious disease which may be caused through a virus through the invasion of the nervous system. It is often spread through ...

Abstract

It has been observed that cAC10 , a monoclonal antibody that is chimeric, has the capacity to cause the in vitro arrest of the growing of the CD30+ cell lines in severe combined immunodeficiency (SCID)in models of mice having Hodgkin disease (Chiarle et al. , 1999; Weiner and Adams, 2000 ). Thus, it can `be said that these antibodies have antitumor activity.

Introduction

The potency of CD30 +-targeted mAb activity was increased by generating an drug and antibody conjugate, “cAC10-vcMMAE”. MMAE is a synthetic analog of dolastatin 10. “cAC10-vcMMAE” has potent cytotoxic activity against CD30 expressing cell lines and has exhibited stability in physiological ...

Abstract

Ginkgo Biloba extract is widely used by older adults as a cognitive enhancer although efficacy studies show inconsistent results. A review was done of three quantitative studies with the hypothesis that once-daily use of Ginkgo Biloba does not help improve the memory of adults aged 50 years or older. One article was a clinical trial on the differences in electrical activity in the brain when Ginkgo Biloba or placebo is used during a working memory test. The second article is also a clinical trial that determined the efficacy of Ginkgo Biloba in reducing cognitive and therefore memory decline in patients with early-stage dementia. ...

The Asthma Control Test (ACT) and the COPD Assessment Test (CAT)

Asthma Control Test (ACT) is a health survey with five questions to measure how individuals with asthma cope with the problem. This test applies to individuals aged twelve and above. It focuses on the main elements of asthma control. The test follows the paradigm shift developed for asthma paying attention to the severity of the disease to its control. It identifies and detects those patients with asthma who have not been able to control asthma well. Minimal important differences (MID), developed with ACT helps medical experts identify the significance of a patient’s scores as they receive treatment over time (1). ...

Introduction

Teratogen is broadly defined as an environmental agent capable of causing abnormal prenatal variation in form or function. In other words, it can be any environmental factor that can produce a permanent abnormality in structure or function of an embryo or fetus or restriction of growth of an infant (Gilbert-Barness, 2010). In prenatal life, exposure to teratogens may even lead to death of the embryo or fetus. It is estimated that approximately 15% of all congenital structural abnormalities observed in a child are due to exposure to some kind of teratogens during the prenatal life (Brent, 2001). A larger number of ...

Report Supporting Purchase of an

Executive Summary The present report provides the support and justification for the purchase of an electronic medication administration records (eMAR) system for the hospital. Medication errors are a serious concern within the business of healthcare and information technology is now available to address the issues causing many of the more egregious problems in this area. In particular, eMAR systems have proven to increase the chances of the right patient receiving the right medication in the right dose through the right route at the right time. These aspects of patient care are fundamental to high quality and are too important ...

Homeostasis is dependent on the precision of the organs and organ system regulations in the body. The nervous system works together with the nervous system to regulate and offer coordination to the activities of almost all other parts of the body. Just like the nervous system, the endocrine system uses chemical known as hormones to communicate with other parts of the body. A hormone molecule is a specific messenger that is synthesized and released by specialized cells known as an endocrine gland. The endocrine glands are ductless with the hormones being released into the blood directly and taken to the ...

Community Health Nurse

Hypothyroidism is a clinical syndrome in which there is either deficiency or absence of thyroid hormone in the body. This manifests as a decrease in the metabolic rate in the body, which is seen as a slowing in physical and mental activity in the body. (Orlander, 2013) Thyroid function is controlled by two other organs, the hypothalamus and the pituitary gland. A defect in function of any of these two organs can lead to hypothyroidism. Moreover, localized disease of the thyroid gland itself can also lead to hypothyroidism. Hypothyroidism is usually a primary pathology in which there is inability of the thyroid ...

Abstract

There have been several instances where a drug has been developed for medicinal purposes but has eventually become more popular as an intoxicant. Ecstasy and Molly are two of the most prominent MDMAs today. While they differ in the manner in which they are consumed as well as the intensity of their reaction, the impact they have on the mind and health of a human being is mostly the same. This paper addresses the characteristics of each and traces its impact. Addiction and intoxication by several substances have been used as a common way to find bliss and pleasure since the ...