Essays on Chemical Stability

1.0 Introduction

Nano-thermal analysis is a primary technique used in the study of the characteristics of pharmaceutical materials in the initial phase of drug design and development. Some of the drug properties that can be studied using nano-thermal analysis include the spatial distribution of the constituents, shape, and size particularly in multicomponent drug sample. Using nano-thermal procedures the different components of these multicomponent drugs can be studied and characterized without having to dissociate the drug. The technique is particularly useful in increasing the dissolution of drugs with low water solubility hence improve their bioavailability. This is by facilitating the formation of solid ...

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Introduction and Literature Review

The value for a drug is significantly impacted by the dissolution rate, chemical stability and solubility of the drugs thereby impacting the pharmaceuticals efficiency as well. In the pharmaceutical industry multi-component crystals such as hydrates, solvates, co-crystals and salts have a major role during the design of new solids. Solid does not self-crystallize. It crystallizes in varied forms depicting random crystal properties. Various approaches are used to modify solids like Salting, Solvation, Hydration, and Polymorphism. Apart from these approaches, Co-Crystallization is a promising new approach to modifying solids (Nauha, ...