(Author’s affiliation) Diabetes is a polygenic disease characterized by significantly higher levels of glucose in the blood. In this disorder, metabolic disorders lead to persistent thirst (polydipsia) and excessive level of urination (polyuria). Diabetes is caused by insulin-related disturbances in the body. In healthy human beings, pancreatic β cells have insulin that is found as a hexamer having three insulin dimers attached together by two central zinc ions. The insulin monomer has a 21-residue A chain as well as a 30-residue B chain. These chains are cross-linked by two disulfide bridges, i.e. CysA20-CysB19 and CysA7-CysB7. There is also a ...
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The peptide hormones are proteinous in nature and may have 3 to 200 amino acids residues. This class of hormones includes all the hormones of the hypothalamus and pituitary, as well as insulin and glucagon of pancreas. Peptide hormones are named based on their endocrine activity rather than their chemical structure; for example, growth hormone is thus named because one of its effects is to stimulate growth. The structure of a particular peptide hormone can vary among different species, with some homology between close relatives. Some small peptides are identical; for example, GnRH is identical among mammals but different in ...
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