Summary of Article
INTRODUCTION Altered oligonucleotides, specifically, labeled RNA serve as important tools in biochemical and biomedical research and have been commonly utilized for therapeutic and analytical purposes . Although there are many studies on post-synthetic techniques on DNA, such as by Marx et al., very few reports have described the techniques related to RNA. An efficient automated RNA synthesis with an optimal yield is a prerequisite for post-synthetic derivatization. It is a commonly accepted truth that RNA production is much more troublesome and challenging than DNA synthesis, owing to its lesser coupling efficiency in the synthesis cycle along with the requirement to ...
