Essays on Hepatocellular Carcinoma

Transcriptional regulation of gene expression

Gene expression in eukaryotic cells is regulated at transcriptional, post transcriptional and translational levels (Tomizawa,  Lekstrom-Himes, and Xanthopoulos 17). Transcriptional control is the primary means of regulating gene expression. Eukaryotic transcriptional control functions at three levels: modulation of the activities of activators and repressors; variations in chromatin structure; and effect of activators and repressors on assembly of initiation complexes (Lodish et al. 368). Regulation of transcription initiation is the most widespread form of gene control in eukaryotes. However, in some cases, transcription may be attenuated and regulated at subsequent steps, such as during or after the transcription process (Cooper ...

Amongst the major infectious diseases, hepatitis is one of the most important diseases affecting a huge number of populations worldwide. Hepatitis is majorly caused by virus or other contributors to the inflammation of liver. It can be infectious or non-infectious. It is a big concern to deal with the disease as it is responsible for taking huge tolls of life with its remarkable symptoms in function loss of the liver due to factors like liver scarring (cirrhosis) or liver cancer (hepatocellular carcinoma) in extreme cases (NHS, 2016). Viral hepatitis is considered to be the cause of hepatitis occurrence in ...