Medical genomic can be defined as the utilization of genome-based information in the making of clinical decisions. A broader concept, personalized medicine, is often used to describe the models of healthcare that emphasize the application of an individual’s unique environmental, genomic, genetic, and clinical information to the treatment and prevention of diseases (Brunicardi; Offit). In their practice, doctors combine the results of patient data, which include individual genomic information, family history, medical history, conventional test results, and symptoms. The combination of the data allows the physicians to diagnose diseases accurately and personalize treatment strategies (Alzu’bi et al.). ...
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Abstract
Cancer of the lungs is among the leading causes of cancer in the world. It has two forms; small cell lung cancer (SCLC), and non-small-cell lung cancer (NSCLC). NSCLC constitutes about 85% of cases of lung cancer. Epidermal growth factor receptor (EGFR) and its mutations are found to have an important role in this cancer. Therefore, EGFR tyrosine kinase inhibitors (TKIs) can work effectively against NSCLC. Gefitinib, which is a first generation TKI, and afatinib, which is a second-generation TKI, are effective as a first-line therapy for advanced NSCLC. Erlotinib is effective as a second-line therapy for advanced NSCLC. ...
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