Essays on Egfr

Introduction

In recent decades, trends in diets tailored to promote weight loss have resulted in a significant increase in the intake of protein, particular in people with overweight and obesity issues. Accordingly, researchers have questioned the benefits or risks linked to the habitual consumption of “dietary protein in excess of recommended intakes” (Martin et al., 2005). In general, the primary concern has involved the possibility that diets rich in protein may increase hyperfiltration and, hence, exacerbate renal damage. Nevertheless, the potential link between protein-rich diets and renal damage has also been questioned due to an absence of adequate clinical evidence. ...

Cancer is the second leading cause of death in the United States. It is a term given to a series of diseases in which the cells within human body grow at an abnormal rate, thereby damaging healthy tissues . While normal cells grow and die at a specific rate according to the requirements of human body, the growth of cells is extreme when compared to the death of cells in cancerous patients. Such an abnormal growth in turn leads to tumors, which consist of a huge mass of tissues. However, in patients suffering with cancer related to the blood, there ...

Abstract

Cancer of the lungs is among the leading causes of cancer in the world. It has two forms; small cell lung cancer (SCLC), and non-small-cell lung cancer (NSCLC). NSCLC constitutes about 85% of cases of lung cancer. Epidermal growth factor receptor (EGFR) and its mutations are found to have an important role in this cancer. Therefore, EGFR tyrosine kinase inhibitors (TKIs) can work effectively against NSCLC. Gefitinib, which is a first generation TKI, and afatinib, which is a second-generation TKI, are effective as a first-line therapy for advanced NSCLC. Erlotinib is effective as a second-line therapy for advanced NSCLC. ...