Essays on Genomic

Introduction

Exom sequencing is also known as whole exom sequencing (WES). This sequencing technique is used to sequence all the expressed genes in a genome also called as exom. It is one of the most widely used targeted sequencing methods. The exom which is the protein coding region of the human genome consists of less than 2% of the genetic code. This region is responsible for containing more than 85% of known disease-related variants. Thus, whole exom sequencing is a cost-effective alternative to whole genome sequencing (WGS). This technique is efficient in identifying coding variants across a wide range of ...

Abstract

The ecological settings in an ecosystem change from time to time. The changes in the ecological settings are brought about by a plethora of factors. Through evolution, the organisms that live in the ecosystem also change to adapt to the aforementioned ecological changes. The adaptation of the organisms to the ecological changes yields variations because different organisms and even organisms of the same species are exposed to the elements to different levels. Man has a significant role to play in the ecological changes. Through his economic activities, the effect on ecosystems has been both positive and negative. Urbanization as ...

Genetic counselling has been described as the process by which an individual fully understands and adapts to the contribution of genetic makeup in the medical and physiological state of the individual along with its influence on the familial implications of a disease condition [1]. Genomic medicine is at an all-time high in these years of fast developing technology in medicine [2]. The traditional process of genetic medicine and counselling involves the collection of data and interpretation of the history of pathology in the familial background of the individual along with the assessment of risks, informed consent, and psychosocial analysis ...

Introduction

Genetic counselling is defined as the information, guidance, and support provided by a genetic counsellor or medical geneticist to an individual, a couple, or a family about a genetic condition. The information may help the client (affected individual or family) understand how a gene variant underlies an observed phenotype, disease prognosis, and the probability of transmission to progeny. Apart from information to help the client make informed decisions about lifestyle, treatment, and reproduction, a counsellor provides psychosocial support to minimize the adverse psychological, intrafamilial, and social consequences of genetic testing. Therefore, genetic counselling has an educational as well as ...

Medical genomic can be defined as the utilization of genome-based information in the making of clinical decisions. A broader concept, personalized medicine, is often used to describe the models of healthcare that emphasize the application of an individual’s unique environmental, genomic, genetic, and clinical information to the treatment and prevention of diseases (Brunicardi; Offit). In their practice, doctors combine the results of patient data, which include individual genomic information, family history, medical history, conventional test results, and symptoms. The combination of the data allows the physicians to diagnose diseases accurately and personalize treatment strategies (Alzu’bi et al.). ...

Human Genome Evolution and Disease

Genome evolution is one of the key aspects that have helped determine the overall position of human beings from a scientific perspective, as it focuses more on providing scientists with an understanding of the changes occurring within the human body (Tomkins, 2016, p.261). The study of genome evolution has focused more on evaluating the changes in structure, otherwise referred to as a sequence, and size of the human gene within a given period. The study provides scientists with a better understanding of the changes occurring within the human body as well as some of the changes that human beings ...

Introduction

Atherosclerotic cardiovascular disease (CVD) involves peripheral circulation, the brain, and the heart. The disease is a primary health issue in many countries around the world (Sawhney, et al., 2012). CVD develops through complex processes involving novel risk markers and common risk factors. Decades of research have demonstrated that a sibling’s or parent’s family history is linked to the development of atherosclerotic CVD (Gupta et al., 2013; Nelson, 2013; Imes and Lewis, 2014), which manifests as peripheral arterial disorder, stroke, and coronary heart disorder (CHD). Various Mendelian disorders have also been shown to contribute to atherosclerotic CVD. Although ...

Abstract

In the last century, the knowledge of molecular biology has increased, opening new opportunities for addressing different diseases that have been affecting all populations. Before, genome and proteomic studies were seen as complicated field due to inability to get significance understanding of disease components at the molecular level. However, with the expansion of molecular biology, different techniques and tools have been developed to aid diagnosis and treatment of diseases. In this study, these tools have been investigated to understand how the knowledge on molecular diagnosis helps in detection and treatment of diseases. This study focused on the application of ...

Genetic and genomic knowledge is a vital part of being a good nurse and meeting all of the competencies that are required to care for patients. There are a large number of genetic diseases, for example, and the field is extremely fast-paced. This makes keeping up-to-date with the information available important but challenging. It was an interesting process learning about all of the various elements of genetic information and how it can be used in nursing as well as generally assisting all health care professionals. The purpose of this paper is to discuss some of the information that I ...

The quality of nursing care in the Dominican Republic has been subject to extensive research on numerous occasions. In the recent years, the government has been focused on enhancing the quality of maternity care across all the hospitals with the aim of reducing the rate of mortality rate through childbirth. It has attracted the attention of many scholars, especially because the nation is known for its highly trained attendants and universal institutionalized deliveries. The quality of medical care provided varies across the various medical institutions (Schumacher, 2010). In the recent years, the rate of Dominican Republican immigrants into the ...

Introduction

The large production of bisphenol A (BPA) in the world has been documented because of the increased usage of the same in various industries. The most critical industries that have been using this BPA include those manufacturing containers for foods and beverages, cigarette filters, thermal receipts as well as paper currency. With such a huge provision, it is critical that the basis of such developments only emanates from making the right choices over its uses because its production to a total of 2.7 million tons could be disastrous to the body. The main reasoning here is that the chemical ...

Implications of Change in Healthcare Delivery System on nurse leadership

Technology drives most of the healthcare delivery system and the changing technology has resulted in the transforming face of modern healthcare system. The practice of nursing becomes quite dynamic when seen in purview of the technological advancements and their implications (Melnyk et al., 2012). For example, genetics and genomic field has encountered a substantial change as large number of diseases, risk factors, therapies and treatments have genomic elements which are influenced by lifestyle and environmental factors, thus having a greater impact on nursing practice. This compels the nurse leaders know more about genomic and genetics to effectually teach and ...

Could there be a way for consumers to gain information on their predisposition to diseases or to tailor fit health care according to their genetic predisposition? Due to the onset of high technology, it is now possible for people to acquire their genetic information through direct-to-consumer (DTC) marketing of personal genetic (PG) and personal genomic (PGM) testing. This is especially useful when they want to be knowledgeable about their inherited susceptibility to disease or to have disease treatment tailored fit. Direct to consumer genetic testing has both risks and potential benefits. I believe that consumers should have direct access ...

Almost every nurse will come across clinical situations that pose ethical dilemma in their practice. In this paper, we look into the ethical dilemma associated with genomic and genetic issues in acute pediatric care settings. Genetic testing and gene based therapies are an integral part of pediatrics. Genetic diseases are commonly identified in the early days of life. Approximately, 53 out of 1000 children, are diagnosed with a disease that is linked to a genetic etiology. As front desk executives, nurses are more likely to participate in activities that involve genomic testing and gene based therapies. The advent of ...

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Introduction

Polymerase Chain Reaction (PCR) is a very influential technique that helps in amplifying the specific segments of DNA. This biochemical procedure is performed in-vitro that is quite different from cloning. This technique is a fusion of synthesis protocol of distinct repeated segments of DNA and thermostable DNA polymerase application that has given scientists a very potent analytical, immunological and molecular technique used prevalently in clinical laboratory science (Garibyan & Avashia, 2013). PCR is based on three primary steps that include denaturation of the template into single strands, annealing ...

Question 1

Compare and contrast the concept of metagenome and microbiome. The microbiome is a term used in describing the entire habitat; it includes microorganisms and their genomes and the surrounding environmental conditions. The microbiome is defined based on the biotic and abiotic factors in a specified environment. On the other hand, metagnome can be defined as a collection of genes and genomes normally from the members of the microbiota. Microbiota is an ecological community that includes symbiotic and pathogenic microorganisms that share our body space. The analysis of microbiome can be done for a large number of samples and can ...

Suppliers:

Amersham Biosciences Uppsala, Sweden Becton, Dickinson and Company (BD) Ireland, UK Bio Basic Inc. Ontario, Canada Biometra (an analytik Jena company) Göttingen, Germany

Bio-Rad California, USA

Biotek Instruments. Inc. Vermont, USA

Boeco Hamburg, Germany

Damad, The National Medical Products co. Ltd Riyadh, Saudi Arabia Eppendorf Hamburg, Germany Eurofins MWG Operon LLC Alabama, USA GE healthcare Buckinghamshire, UK GFL Gesellschaft for Labortechnik Burgwedel, Germany Health o meter® Professional Scales Florida, USA Labcaire New York, USA Lab-Line Kerala, India LG Electronics Seoul, South Korea New England Biolabs Massachusetts, USA Nichipet Texas, USA Panreac Darmstadt, Germany Promega Wisconsin, USA Pyrex California, USA Qiagen Boston, USA Sanyo Biomedical ...

Procedure 1: Locating the position of a gene

In Ensembl: Search the internet link to the ensemble website: http://www.ensembl.org/index.html On the Genome Browser located on the web page, select the human genome – GRCh38.p5 – to obtain various sub-topics about the genome. Type the name of the gene in the search box of the human genome webpage. The MSRA homepage will contain a summarized description of the gene, including the including the location of the chromosome, its size, and the start and finish nucleotide.

In NCBI:

Search the link http://www.ncbi.nlm.nih.gov/ to obtain the NCBI homepage. Type the gene name MSRA on the gene search box. From the list of search results, ...

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Introduction

Genome imprinting is the latest technique that has genetically modified the face of infertility; it is an epigenetic phenomenon through which the parental origin of a gene is determined based on its expression. 1 There are a vast number of genes in mammals that are marked with their parental origin, and the result of this phenomenon is a single parental allele. These marked genes are known as “imprinted.” They rely on the epigenetic machinery determining their parental identity and maintaining their origin-specific gene expression. There are 100 imprinted genes estimated in human and 200 ...

Background information

Malaria, a mosquito borne transmissible disease of both human beings and some animals is a pertinent disease in the 21st century which accounts for more than 650, 000 deaths annually (WHO, 1147). The prevalence of malaria is highest in the tropical and subtropical regions. Adverse effects of the disease is an equally major public health issue that affects maternal and child health. In the developing countries, malaria is a leading cause of maternal and child health. Consequentially, it is a pertinent public health disease. This manuscript offers a succinct analysis of the disease while appraising its causative agents, life ...

Chimpanzees are genetically very close to human beings. As a result, these animals are very useful when conducting human biomedical and behavioral research (National Academies of Science). Plenty of research have been done using these animals leading to great developments in public health. Although these primates have helped researchers to make plenty of contribution to public health, some people feel that other alternatives should be considered. It is true that chimpanzees have played a vital role in medical research. However, their use as animal models is no longer appealing as technology provides alternatives. Complete discontinuation of chimpanzees in laboratories ...

GMO is genetically modified organism. It has become very wide spread in our world. However, not all the people are aware of what GMO is and what it does to their bodies. Many consumers are buying products at the grocery store and are clueless that they have become a part of the global experiment. Nowadays many activists are trying to explain people what GMO is and how it works. David Suzuki and BBC Documentary “Ghost in Your Genes” provide a lot of explanation to the issue of GMO in the modern world. Overpopulation is one of the main reasons ...