Essays on Genome

Introduction

Exom sequencing is also known as whole exom sequencing (WES). This sequencing technique is used to sequence all the expressed genes in a genome also called as exom. It is one of the most widely used targeted sequencing methods. The exom which is the protein coding region of the human genome consists of less than 2% of the genetic code. This region is responsible for containing more than 85% of known disease-related variants. Thus, whole exom sequencing is a cost-effective alternative to whole genome sequencing (WGS). This technique is efficient in identifying coding variants across a wide range of ...

Abstract

The ecological settings in an ecosystem change from time to time. The changes in the ecological settings are brought about by a plethora of factors. Through evolution, the organisms that live in the ecosystem also change to adapt to the aforementioned ecological changes. The adaptation of the organisms to the ecological changes yields variations because different organisms and even organisms of the same species are exposed to the elements to different levels. Man has a significant role to play in the ecological changes. Through his economic activities, the effect on ecosystems has been both positive and negative. Urbanization as ...

Genetic counselling has been described as the process by which an individual fully understands and adapts to the contribution of genetic makeup in the medical and physiological state of the individual along with its influence on the familial implications of a disease condition [1]. Genomic medicine is at an all-time high in these years of fast developing technology in medicine [2]. The traditional process of genetic medicine and counselling involves the collection of data and interpretation of the history of pathology in the familial background of the individual along with the assessment of risks, informed consent, and psychosocial analysis ...

Introduction

The Ebola virus has existed for centuries. Like all life forms and viruses, it has been changing and adapting since the beginning of time to survive. Despite this the disease did not make itself known until the twentieth century. However, once the virus revealed itself only three major outbreaks have occurred. There were two in 1976 and one which took started in 2014 (CDC, 2015). The latest outbreak has been the longest and worst, effecting numerous countries such as, Mali, Nigeria, Liberia and Senegal in West Africa (CDC, 2015). This paper will look at the scientific aspects of the ...

INTRODUCTION

Modern science and technology has made fascinating discoveries and incredible innovations. There have been amazing advances in all areas and disciplines from engineering and robotics to science and medicine. It is the latter that has made some of the greatest advances and innovations. Human beings learn more and more everyday about how to treat illnesses and prevent diseases. They have also learned so much about the how the human body works; right down to the genes that make all living things what they are. It is possible today for scientists to understand how genes affect traits and that sometimes ...

Introduction

Migraine is a common type of headache disorder which is characterized by moderate to severe recurrent headache. Migraine headaches are generally severe and could last up to 3 days, wherein the pain affects half of the head but the pain is pulsating in nature. People with acute migraine headache may have suffer from sensitivity to light, vomiting, nausea, and sensitivity to smell and sound. In some cases, the pain may become severe and worsen after physical activity. In 1/3rd of patients with migraine, a short period of visual disturbance or aura occurs which is an indication that the pain ...

Medical genomic can be defined as the utilization of genome-based information in the making of clinical decisions. A broader concept, personalized medicine, is often used to describe the models of healthcare that emphasize the application of an individual’s unique environmental, genomic, genetic, and clinical information to the treatment and prevention of diseases (Brunicardi; Offit). In their practice, doctors combine the results of patient data, which include individual genomic information, family history, medical history, conventional test results, and symptoms. The combination of the data allows the physicians to diagnose diseases accurately and personalize treatment strategies (Alzu’bi et al.). ...

Human Genome Evolution and Disease

Genome evolution is one of the key aspects that have helped determine the overall position of human beings from a scientific perspective, as it focuses more on providing scientists with an understanding of the changes occurring within the human body (Tomkins, 2016, p.261). The study of genome evolution has focused more on evaluating the changes in structure, otherwise referred to as a sequence, and size of the human gene within a given period. The study provides scientists with a better understanding of the changes occurring within the human body as well as some of the changes that human beings ...

Introduction

Atherosclerotic cardiovascular disease (CVD) involves peripheral circulation, the brain, and the heart. The disease is a primary health issue in many countries around the world (Sawhney, et al., 2012). CVD develops through complex processes involving novel risk markers and common risk factors. Decades of research have demonstrated that a sibling’s or parent’s family history is linked to the development of atherosclerotic CVD (Gupta et al., 2013; Nelson, 2013; Imes and Lewis, 2014), which manifests as peripheral arterial disorder, stroke, and coronary heart disorder (CHD). Various Mendelian disorders have also been shown to contribute to atherosclerotic CVD. Although ...

Abstract

In the last century, the knowledge of molecular biology has increased, opening new opportunities for addressing different diseases that have been affecting all populations. Before, genome and proteomic studies were seen as complicated field due to inability to get significance understanding of disease components at the molecular level. However, with the expansion of molecular biology, different techniques and tools have been developed to aid diagnosis and treatment of diseases. In this study, these tools have been investigated to understand how the knowledge on molecular diagnosis helps in detection and treatment of diseases. This study focused on the application of ...

The development of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology has transformed genetics and gene editing. CRISPR’s precision and efficiency have allowed scientists to control and modify genetic material with unparalleled precision. This technology, however, presents a slew of ethical issues about its possible ramifications and implications. This essay will outline the CRISPR technology, discuss the ethical problems with CRISPR and conflicts surrounding it, as well as argue whether gene editing is ethical in general.

What Is the CRISPR Technology?

CRISPR technology is a genetic technique that allows researchers to alter particular genes in an organism’s DNA. The method employs a class of enzymes ...

The rediscovery of Mendel's works on heredity in 1900 became the foundation to investigate more on genetics. However, the acceleration of the study of genetics was slow, taking more than half a century later for Watson and Crick to crack the chemical basis of heredity. In fact, their proposal, the double helical structure of DNA, became the beginning of modern biology. Over the next 30 years, the advent of recombinant DNA technology allowed us to sequence specific DNA segments (Collins & McKusick, 2001). Note that mapping specific regions of a particular DNA offers explanations to many traits, including behaviors, disorders, ...

A proposal in partial fulfillment of the requirements for the degree of

Introduction Wheat (Triticum sp.), an extensively adapted crop, is one of the primitive and primary staple food crops in the world. Wheat is cultivated from temperate; dry to irrigated or rain-fed areas, to warm, humid or cold conditions. Such a high adaptability is attributed to its intricate genome (Acevedo et al., 2002). Wheat cultivation covers more land area compared to other commercial crops and endures to be an essential food grain for humans (Curtis, 2002). Estimations reveal that by 2050, the population of the world will reach 9.1 billion (34 percent greater than today); correspondingly, the food requirement and ...

The article "Scientists Talk Privately About Creating A Synthetic Human Genome", written by Andrew Pollack, is about the research made by the author and other scientists in the sphere of sunthetic human genome creation. They have managed to contemplate the human genome fabrication within the modern synthetic biology. They took various forms and components, linked them in order to create differently new forms with the aim of creating the new human DNA by use of chemicals. In general, synthetic biology considers the switches of genes, and the scientists made there investigations within that sphere. In recent years, instead of ...

Vid30 complex participation in the degradation of CDC25 in yeast and their role in Ras/ cAMP/ PKA pathway

Background: Unicellular organisms such as Saccharomyces cerevisiae in its total life cycle is exposed to diverse and changing nutrient conditions. Thus, in order to survive and achieve a competitive advantage, it has adapted itself such that it not only uses the wide range of available nutrient sources but also the sources that are nutrient rich. It mainly uses fructose and glucose by rapidly fermenting to alcohol. In response to these nutrient conditions, the intracellular trafficking transcription and turnover of protein from nutrient transporters (e.g. Hxts) get regulated. Therefore, when the availability of the glucose increases, the expression of low- ...

The article "Scientists Talk Privately About Creating A Synthetic Human Genome", written by Andrew Pollack, is about the research made by the author and other scientists in the sphere of the coordinated oscillations. They have managed to contemplate the human genome fabrication within the modern synthetic biology. They took various forms and components, linked them in order to create differently new forms with the aim of creating the new human DNA by use of chemicals. In general, synthetic biology considers the switches of genes, and the scientists made there investigations within that sphere. In recent years, instead of the ...

Food is a basic commodity needed to sustain life and as such, it must be safe to eat. Despite the innumerable controversies that abound regarding the ingredients and additives in our food and sage advice from many professional sources and health gurus arguing to the contrary, this paper will support the thesis that, for most people, our food supply is safe. While accepting that prepared foods may contain additives and preservatives, these are necessary to allow manufacturers to bring food safely into our homes. Preservatives and additives are necessary to ensure that our food supply is safe, but ultimately ...

Question 3: Immigration and Citizenship

Immigration into the United States has spiraled upward during the past several years. This is as a result of the changing world economy. Many US citizens are apprehensive towards extending citizenship to new immigrants. This is as a result of many factors. Some of these factors include; the view held by some, that immigrants add to the tax burden as they are often low-skilled and are unable to pay enough taxes to cover their benefits, some citizens also believe that immigrants take jobs that belong to true Americans, there is also the cultural concern that some Americans have that ...

Organization:

The human body is home to a variety of organisms ranging from the minute bacteria to eukaryotic mites. Demodex folliculorum is a small arthropod that lives in human hair follicles and sebaceous glands. D. folliculorum and the closely related D. brevis live in a commensal relationship on humans and are harmless in the normal course of events. Demodex was first discovered by Henle in 1841 and described by Simon Akbulatova in 1842. The existence of the mite in cadavers was established by Stcherbatchoff in 1903 and later by Gmeiner in 1908. Riechers and Kopf in 1969 showed that maximum ...

Abrigo do Lagar Velho is a rock-shelter in the Portuguese valley that is famous for the stratigraphic range of the Upper Paleolithic human occupations within that area.

Absolute dating technique (chronometric dating) refers to the process of revealing the age on a certain time scale.

Acclimatization is the response of an organism to a gradual change in environmental conditions by adjusting and sustaining within these changes. Acheulian (Acheulean) is a tool made of stone that had round cutting edges and was used during the Lower Palaeolithic era.

Adolescent growth spurt refers to the sharp growth in height and weight rates t during adolescence.

Aegyptopithecus refers to the extinct primate of the Oligocene Period, resembling a modern-day lemur, whose fossils were found in Egypt. Afar Triangle is the region that is part of the ...

The advances in biotechnological field have made it possible to understand the genetic role behind molecular mechanisms to large extents. This in depth understanding of biological processes has paved ways to treat the untreatable aiding the human existence in multitudes of aspects like food, health, bioremediation, mining, biopharmaceutical production and much more. This microbial world is vast and has been a platform for human beings to explore their biological systems as they are simpler cells and can be manipulated with much ease than complex systems. The DNA harnessed within the cells are the molecular entities that have been targeted ...

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Introduction

Polymerase Chain Reaction (PCR) is a very influential technique that helps in amplifying the specific segments of DNA. This biochemical procedure is performed in-vitro that is quite different from cloning. This technique is a fusion of synthesis protocol of distinct repeated segments of DNA and thermostable DNA polymerase application that has given scientists a very potent analytical, immunological and molecular technique used prevalently in clinical laboratory science (Garibyan & Avashia, 2013). PCR is based on three primary steps that include denaturation of the template into single strands, annealing ...

Ethics refers to the essential principles of right and wrong and those that govern how things should happen in the society. They often help in informing people’s judgment, as well as how individuals should associate with one another in life. Various principles act as the benchmarks for basing conclusions. Autonomy respect, non-maleficence (doing no harm), beneficence, truthfulness, and fairness are some of the principles governing ethics in the society. This essay analyzes the ethical issues present in the Kazuo Ishiguro’s novel, ‘Never Let me Go’ and the commonly known scientific research project called ‘The Genome Project.' It ...

In generic sense of the term, a "genetically modified organism" is a living organism whose genome has been altered artificially. This understanding includes all the possible ways of modifying the genetic information, from crosses method for genetic engineering tools. From a legislative point of view, a large number of countries and organizations use a more restrictive definition in reference to that specified in the Cartagena Protocol, which means "living modified organism" "any organization living with a novel combination of genetic material. " However, this definition is not universally recognized. Some countries, including the United States, do not make this use ...

Question 1

Compare and contrast the concept of metagenome and microbiome. The microbiome is a term used in describing the entire habitat; it includes microorganisms and their genomes and the surrounding environmental conditions. The microbiome is defined based on the biotic and abiotic factors in a specified environment. On the other hand, metagnome can be defined as a collection of genes and genomes normally from the members of the microbiota. Microbiota is an ecological community that includes symbiotic and pathogenic microorganisms that share our body space. The analysis of microbiome can be done for a large number of samples and can ...

Introduction

The treatment for multitudes of diseases and disorders resulting from genetic reasons have been ambiguous since long as the only cure could be the correction of genes and DNA in the specific region. Gene therapy gave a promising horizon to the correction of such genetic defects whereby molecular tools are applied to reverse the mutation or any other changes in the DNA. The advancing biomedical research have offered several tools for gene therapy since last few decades that have been able to perform the desired roles but with one or the other limitations. Lately, CRISPR-Cas9 based tools for gene ...

Abstract

Transformation remains, and hugely significant tool in extending the borders of life sciences and medicine. It can be referred as fixing intracellular DNA into a bacteria or organism through the vector, thus transforming it. This paper uses plasmid pUC18, self-reproducing circular/spherical strands of genes that may be modified. After the bacteria absorb the vector, some proteins not usually synthesized will occur. In this study, a system has been developed to monitor the transmittance of different DNA (genes) from a genetically transformed strain of Saccharomyces cerevisiae to E. coli. This mechanism is centered on yeast strains that contain several integrated ...

Procedure 1: Locating the position of a gene

In Ensembl: Search the internet link to the ensemble website: http://www.ensembl.org/index.html On the Genome Browser located on the web page, select the human genome – GRCh38.p5 – to obtain various sub-topics about the genome. Type the name of the gene in the search box of the human genome webpage. The MSRA homepage will contain a summarized description of the gene, including the including the location of the chromosome, its size, and the start and finish nucleotide.

In NCBI:

Search the link http://www.ncbi.nlm.nih.gov/ to obtain the NCBI homepage. Type the gene name MSRA on the gene search box. From the list of search results, ...

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Introduction

Genome imprinting is the latest technique that has genetically modified the face of infertility; it is an epigenetic phenomenon through which the parental origin of a gene is determined based on its expression. 1 There are a vast number of genes in mammals that are marked with their parental origin, and the result of this phenomenon is a single parental allele. These marked genes are known as “imprinted.” They rely on the epigenetic machinery determining their parental identity and maintaining their origin-specific gene expression. There are 100 imprinted genes estimated in human and 200 ...

Biology

(Department)

DNA and its importance in our lives

Introduction Deoxyribonucleic acid (DNA) is a long linear polymer located in the nucleus of a cell. It is developed from nucleotides and shaped like a double helix. It is related to the transmission of hereditary information from one generation to the second generation. DNA contains the information for the development as well as reproduction of an organism, thereby leading to a normal life. In the year 1953, James Watson, a biologist, and Francis Crick, a physicist, discovered the structure of DNA in a laboratory in England (LEROY, 2003). The structure of DNA helped scientists to know the process ...

According to Palladino (2006), the Human Genome Project (HGP) was a scientific research project carried out internationally for thirteen years. This project was initiated by the U.S government with the support of other contributors such as public and private researchers with the goal of tracing and mapping nucleotides as found in the human Haploid Reference Genome. In other words the project was driven by the need and interest to collect information about the human genome. In this regard, the project was carried out in order to determine the sequence followed by chemical base pairs which are responsible for the ...

Transgenic animal is one that harbors a foreign gene in its genome. It has been inserted into its genome, deliberately through human effort. The foreign gene has been constructed and inserted into the animal, using recombinant DNA technology. Different technologies enable the recombinant gene to be inserted into the transgenic animal and they are: embryonic stem cell method, pro-nucleus method, retro virus mediated gene transfer. The transgenic gene in the animal serves different functions. For example, it contributes to increased growth rate or increased disease resistance or enhances the nutrient value of a food animal or improves muscle mass ...

Mirna Salim

Introduction Cats have been living with us for thousands of years. As opposed to other domestic animals like cows and sheep that provide as with food and other raw materials, it has never been clear the main reason why human domesticated cats. Some schools of thought believe that cat was domesticated to help human eradicate rodents which were destroying crops. However, others believe that cats were domesticated just to be pets, to keep human company. This research will not major in the reason as to why cat was domesticated, but rather will focus on the origin of the domesticated ...

Technology advancement in the medical sector has had an important contribution in the pathology of many diseases. One of the innovations has been, testing human DNA, commonly referred to as Genetic testing. The procedure involves determining the DNA sequence and changes in the DNA sequence of specific genomes in a human body (McCormick and Connors 317). The tests are used to diagnose traits and diseases, assess the severity of a given disease, and determine gene changes that can be inherited from one generation to another, determining medical treatments and gene changes that have a higher risk of causing a ...

I am an individual with varied interests. However, I have always remained fascinated by the science of the DNA Double Helix.  My fascination in DNA Double Helix and its functionality goes back to the 6th grade when I stumbled over my cousin’s biology assignments on the structure and functionality of the DNA Double Helix. I remember asking him to explain it to me. He said a lot of staff I could not understand then, but the only thing that caught my attention is conservative nature of DNA Double Helix. My focus on the DNA Double Helix grew fonder ...

Lis Rodriguez

Lab 1 ASA College Abstract Patau’s syndrome is a rare genetic disorder that involves trisomy 13. The condition is characterised by either an extra copy of the autosomal chromosome number 13 or a translocation to chromosome 13 from another chromosome. There are severe symptoms observed in the unborn and newborn children having this defect. Polydactyly, cleft lips, physical retardation, mental retardation, heart defects are few of the many symptoms. The disease can be diagnosed during gestation via screening methods followed by several analytical procedures like FISH, karyotyping and microarray on samples of blood and serum from the pregnant ...

Hepatitis type B viral infection is a common and serious disease that is caused by the hepatitis B virus (HBV). HBV is a DNA virus with partial double strands and belongs to the Hepadnaviridae family. One-third of the world’s population is believed to have been infected by HBV of which 6% have chronic HBV infection. Depending on the rate of infection and carrier rate, the world is divided into low, medium and high endemicity regions (Franco et al. 75). The HBV resides in the bodily fluids of an infected individual and is transmitted via the same (Aspinall et ...

Precision medicine in Neurodevelopmental diseases

The present lecture focuses on the genomics, its significance in treating current genetic diseases and future scope. Started with the basic introduction of human genome the lecturer presented the most advanced approach of genomics in combating the multiple incurable human diseases via developing tailored mouse models. Human genome includes 3 billion nucleotide bases that are inherited from the parents. Human genome sequencing was one of the greatest achievements of the medical science that have grown rapidly. The total cost for the first sequencing project had been 3 billion USD that lasted for around ten years but now one can ...

Microbe-Host Analysis

Microbe-Host Analysis

Introduction

It is unknown how long Staphylococcus Aureus (S. Aureus or staph) has been on this planet. We have been too busy trying to conquer all of successful attempts that it has made to evade our weapons against to establish an intricate epidemiologic profile of it. We do know when it was discovered to be a harmful bacteria, though. One of the primary toxins of staph, PVL, was first discovered by an assistant in Belgium by the name of H. van de Velde in 1894. He was taking care of some rabbits in a laboratory and noticed a ...

Epigenetics is the process of studying cellular and physiological phenotypic characters within the field of genetics. The study falls within the subject of genetics and the phenotypic differences which are affected by the peripheral environmental matters. These factors are notorious for switching genes on and off and also affect the way in which genes are read by the cells. Therefore, Epigenetics is the study that seeks to establish the dynamics alterations in the transcriptional potential of the cell. The alternations in this case, may or may not be heritable, even though it is controversial to use the term epigenetics ...

Late last year an important discovery about Neanderthal was presented to the public. A 130,000-year-old Neanderthal toe fossil discovered in a cave in Siberia, Russia, allowed scientists to sequence a complete Neanderthal genome. This information is important both in terms of studying Neanderthals, and also understanding of what makes the lineage of humans unique. It will allow scientists to how Neanderthals and Humans interacted and the breeding habits between both species.

Nature was the journal that broke finding to the public in their peer-reviewed journal in an article titled, The complete genome sequence of a Neanderthal from the Altai Mountains. ...

Natural selection can be referred to as a process through which biological traits turn either more or less common within a population as a function of the impact of hereditary traits on the differential reproductive victory of organisms’ interaction with their surroundings. It is a major evolution mechanism. Charles Darwin popularized the term natural selection with an intention to have it compared with artificial selection, now referred to as selective breeding.

There exists variation within every organism’s populations. This takes place partly since random mutations happen in the genome of an organism, and these mutations can be acquired by offspring. All ...

The term genetic enhancement, when used in scientific circles, means the use of genetic engineering skills to modify the characteristics of an individual that are non-pathological in nature. It has come to the fore in the last few decades, thanks to tremendous technological advancements that have been made as far as the human genome is concerned. Of particular importance is the completion of the human genome project which has, now than ever, made it very easy for the scientists to accurately describe the specific gene responsible for certain characteristics in an individual, be it ...

Before the 16th century, the existence of micro-organism had not been discovered. It was until a microscope was invented that micro-organism become a subject of discussion (Barnett 2003). Microbiology is the study of microorganisms or microbes. Microorganisms are the smallest living organisms that cannot be observed with our naked hence they need to be magnified using magnification tools such as microscope. Examples of micro-organisms are bacteria, virus and fungi. Fermentation in simple terms is the conversion of sugar into acid, gases and alcohol by enzymes that act as catalysts (Pumphrey and Julie 1996). Fermentation is a process that occur takes place in ...

There are three grand theories providing theoretical framework for studying human development: psychoanalytic theory, behaviorism and cognitive theory.

The fundamental concepts of the psychoanalytic theory are the underlying forces (inner drives, mental and emotional processes, motives) shaping the personality, behavior, thinking, attitude, decision making, etc. Central to this theory, introduced by Sigmund Freud, is a point of view that a individual in his or her development passes through specific psychosexual stages: oral, anal, phallic, latent and genital. Ericson, who also contributed to the psychoanalytic theory, offered different classification of development stages. Each stage has its unique needs, motivation drivers, challenges and relationships. According to Freud, people act from three major states of the ...

Formation of bone during foetal development occurs through the process of ossification. This process is extremely important to proper bone length, density, and uniform skeletal formation. It is driven by a complex network of genes that code for signalling proteins whose function is to turn the ossification process on, off, or slow it down. Defects in these genes can cause problems with the ossification process, and can lead to conditions of skeletal dysplasia (improper formation of bone). One such condition is Achondroplasia, one of the most common forms of dwarfism, or congenital short stature (Lister Hill National Centre for Biomedical ...

Genetics has progressed over the recent years. Very sophisticated methods of studying genes and researching how species have evolved from one cell into complex animals. The purpose of the research by Lee, Lai, Malik, Saldarriaga, Kelling, and Slamovits at the Canadian Institute for Advanced Research and the Department of Biochemistry and Molecular Biology, Dalhousie University was to observe and gather more information about The Oxyrrhis marina (O. marina). The species is very good for studying about the development of two taxonomic groups of “protists, dinoflagellates and apicomplexans” (1). The molecular structure is simple, so it is at the ...

Business Recommendations Based on Pandora Media Inc.

Business Recommendations Based on Pandora Media Inc.

Pandora Media Inc. is an American based internet radio service provider founded in 2000 and stationed at Oakland in California. This company has pioneered the issuance of personalized radio services through the internet. In the contemporary world, the AM/FM radio is losing its significance and current clients prefer real time based radio services round the clock. Pandora manage over a hundred personalized stations that enable listeners to create their own tailored playlists of unlimited music. The company has launched a project known as the Music Genome Project. This project has and is helping clients ...

In 2003, scientists completed the mapping of the entire human genome. Understanding a human’s genetic makeup allows for all sorts of possibilities, like the cure for diseases. The first use of IVF treatment in 1978, allowed for the prescreening for certain diseases. For example, nowadays the use of preimplantation genetic diagnosis (PGD) allows for the detection of cystic fibrosis, Down syndrome, Tay-Sachs disease, and hemophilia A. This is only the beginning; soon enough parents will be able to pick specific traits that they want passed down. One method of doing this is called germline gene therapy.

This means manipulating ...

Introduction

Sharon Terry (2012) explained that a person’s Family health history can be gathered from a number of resources. These include observing choices one makes on a daily basis; legends and stories shared by older family members as well as the culture of one’s community. Precisely she advocates that everyone should endeavor to collect data pertaining to their family history because it can prolong as well as save lives (Terry, 2012).

In this module I will outline the family history of my co-worker, Sandra. Specific features that would be addressed pertain towards medical, social and common life expectancy indicators referencing the ...

Introduction

Genetics is an evolving field in modern day science that has been drawing attention and funding in abundance. Various healthcare professionals have varying degrees of knowledge on modern day genetics and its applications. Nurses are also required to possess knowledge on genetics, as well as a good practice on ethics pertaining to genetics. However it is still not an area where everybody is comfortable to handle (American Nurses Association, 2001). Since the completion of genome project in 2003, there is a great interest towards the applications of genetic engineering technology in healthcare. Genetic screening for diseases such as diabetes mellitus, various ...

Introduction

Most of the world’s chronic diseases are preventable by long term dietary behavior. Out of the ten major causes of deaths for Americans, diet is a contributing factor to at least five of them. These diseases are such as cardiovascular diseases, cancer and diabetes. A report by the Joint World Health Organization on diet made in 2003 revealed that, most of the world’s chronic diseases can be prevented by regular physical exercise and maintenance of a healthy weight. This finding is valid up to date. According to this report, a person’s genome determined their susceptibility to disease while external ...

Specific Aims

Activation-induced cytidine deaminase (AID) encodes a DNA-editing deaminase, which is a group of the Cytidine Deaminase family (Bello). This protein is concerned in somatic gene conversion, hypermutation, and class-switch recombination of Ig (immunoglobulin genes). Activation-induced cytidine deaminase (AID) has been expressed in B cells at germinal center and starts the events, which lead to class switch recombination of immunoglobulin genes and somatic hypermutation. Additionally to this primary responsibility in immune diversification, deviant targeting of Activation-induced cytidine deaminase activity leads to translocations and point mutations of oncogenes linked with B-cell lymphoma. Lately, AID has been related in active DNA demethylation (Sariah). ...

Article Reflection

Article Reflection

Introduction

Placids can be defined as the endosymbiotic organelles, which substantially rely on the cell of their hosts to survive. Even so, placids are reported to have shown so much diversity in different situations. Therefore, ways through which differences emerge has been addressed. Some of the aspects that contribute to these differences are such as the difference in the lineages from which plastids originated. This is evident given that there are primary and secondary lineages from which the plastids can stem from. Additionally, the cause for the small size of the plastids has been established. Plastids are ...

Police crime control policies

Crime control is paramount for the economic development of any civilized society. The political stability of any nation is measured by the crime rate. Countries that have low crime rates are more attractive to investors and business leaders. The crime rate in the United States of America was high in the 1990s. The cities were controlled by criminal gangs and at times the fights between criminal gangs took place in the streets. The frequency of homicides was relatively high. The residential places were not spared from crime related violence. Law enforcement officers were criticized for being weaklings. The police ...

At present, the consensus view among social scientists reflects the idea that human races are socio-cultural constructions, but the persistence of the notion of a biological reality behind “race” is undoubtedly enduring both in popular culture and among scientists. Garner (2009) offers a sufficiently elaborate explanation for the misconception of race as a biological and genetic reality. A closer look at the socio-cultural reality behind “race” will reveal not only socio-political narratives that systematically re-inscribe racial categorization, but also the commercial and technological themes behind the socio-cultural concept of “race”. Garner (2009, pp. 1-5) emphasizes the reality that the lines between ...

With reference to Biological studies, homology is the presence of shared pedigree between living organisms in terms of evolution. The homology might be in terms of genetical constitution, or physical constitution, to name a few. Here, I have described the evolutionary homology between various phyla supporting the description with a phylogenetic tree.

Genetic code is the combination of DNA and RNA sequences that constitute the amino acid sequences used in the synthesis of an organism's proteins. It is the biochemical basis of heredity and generally, protein coding amino acids is very similar in all eukaryotes and prokaryotes. The principle differences occur ...

#1. Observations Human beings are morphologically diverse. Compared to other primates, human beings show less variation. We differ considerably in our external appearances (eye color, hair color, skin color, hair texture, skin texture, blood group types- A,B, AB and O, height, build, facial features, etc) and our physiology. However despite all these variations, the genome of each and every human being is 99 percent identical (Lai CQ, 2010). It is also interesting to note that humans and chimpanzees share 98 percent of the genome. The study of these genetic variations is very important to geneticists. The allelic ...

Genes are contained in an organelle referred to as mitochondria. This organelle is responsible for providing the body with the energy needed to run all the cellular activities. Mitochondria contain their own genome that is specific to a particular organism. This is essentially distinct from the nuclear genome that is obtained from both the father and mother and is harbored in the nucleus; as the mitochondrion genes are inherited exclusively from the mother. mtDNA occur in numerous numbers in the cell owing to their small size and they do not undergo recombination. They are the genetic markers that have been ...

Abstract

Human XPA is a protein engaged in DNA damage recognition and repair. A mutation in the gene encoding the protein causes an autosomal recessive disorder, xeroderma pigmentosum (XP), which renders an individual sensitive to sunlight and causes skin cancer. XPA is a 273 amino acid protein, which is predominantly localized in the nucleus. It is expressed at both high and moderate levels in several tissues. The protein serves as a damage sensor in a nucleotide excision repair mechanism, through which the damage to a DNA strand is verified and repaired by formation of a newly synthesized strand. Besides this primary NER mechanism, XPA in conjunction ...