Essays on Crean

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Recreational adolescent use of marijuana can result in adult cognitive problems including learning, thinking, and memory problems (Crean, Crane, & Mason, 2011). Marijuana, also known as cannabis, is known to humanity for thousands of years. It is obtained from the hemp plant, known as Cannabis sativa. Marijuana is one of the most popular, easily obtained drugs, and controversial drugs. It contains psychoactive chemicals such as delta-9-tetrahydrocannabinol, which was obtained in the mid-1960s. This is the key chemical behind the development of controversies in this and the last century. Certain others aspects of the endocannabinoid system including cannabinoid ...

- What is Lipinski’s Rule of Five and why is it important to drug design?

Lipinski's rule of five is popular as the Rule of five (RO5) or Pfizer's rule of five. It is a standing rule that evaluates drug likeness in determining whether chemical compounds that have certain biological or pharmacological activities have properties that make it a probable orally active drug for human consumption. This rule is on observing that many medication drugs have lipophilic molecules (Anastas 56). This means that the rule is applicable in drug discovery when lead structures that are pharmacologically active optimized. This increases the activity and compound selectivity insuring proper maintenance of drug-like physicochemical properties as illustrated ...