Essays on Hemolysis

Introduction

Sickle Cell Anemia or Sickle Cell Disease is an inherited blood ailment. Those suffering from Sickle Cell Disease have abnormal S/ sickle hemoglobin in the red blood cells. Hemoglobin is the protein in the blood that aids in carrying oxygen throughout the body. The ailment takes its appellation from the shape of the red blood cells of a person affected by Sickle Cell Disease, which have the shape of a sickle. They are stiff and adhesive rather than a disk like normal cells. The misshapen cells tend to get trapped in the small blood vessels hindering the movement of ...

Overview: Overview: Antigen-antibody reactions are commonly used in immunological assays. In a traditional agglutination assay, the end product is a visible antibody-antigen complex that settles as visible particulate matter in the solution. In other cases, the reaction is invisible and wants the use of a specific enzyme or isotopic probes that can amplify the signal created by the antigen-antibody reaction, so that they can be detected with the naked eye or an ELISA/RIA reader1. Hemagglutination is a visible antigen -antibody assay in which soluble antibodies react with antigen on the surface of (red blood cell) RBC to form a ...

There are many ways how to objectively determine the presence of anemia or in this case AIHA. One of the testes used is the Direct Anti-Globulin Test (DAT), otherwise known as the Coombs test. The goal of the test is to describe the presence of antibodies in the blood plasma or serum. By knowing the number of antibodies, it can be accurately rule whether the patient is suffering from AIHA or other forms of anemia or otherwise. It is often used to check whether the patient is suffering from transfusion reactions and other hemolytic diseases such as AIHA in ...