The team of specialists provided a research on the role of Gleevec in the treatment of insulin resistance and type 2 diabetes. This study was published in the journal Diabetes in 2016 and presents a new intervention for the treatment of type 2 diabetes in adults and children. The main problem is that obesity is widespread nowadays, it results in diabetes, dyslipidemia, hypertension, and cardiovascular diseases. The key idea is that Gleevec can be a novel therapeutic agent for use in insulin resistance and type 2 diabetes only if its potential adverse effects will be removed (Choi 2016). However, ...
Essays on Ligands
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Iridium organometallic complexes
Introduction Iridium organometallic complexes are applied as catalysts, light-emitting diodes, dye-sensitized solar cells, and luminescent agents for cells imaging.1 Due to the wide application area, the scientists perform research on preparation, characterization and physical and chemical properties of iridium organometallic complexes.
The oxidation state in complex compound refers to the charge of the metal, which it would have in a simple ionic compound. The configuration of d-orbitals (dn) indicates the number of valence electrons in free metal of the same oxidation state. The iridium electronic configuration is [Xe] 4f145d76s2, yet the s-electrons transfer to d-orbital to form 5d9. The ...
1. a. The pKa value of an amino acid is an indication of how strong or weak an amino acid is, based on the said acid’s dissociation constant. An amino acid that has a high pKa value is weaker than on that has a low pka value. Given that an acid’s dissociation constant is Ka, the pKa value is given by the formula: pKa = -log10Ka pH = pKa + log ([A-]/[HA]),It follows that for Cys12, 7.4= 7.2 + log([Cys-]/[HCys]) 7.4-7.2 = log([Cys-]/[HCys]) 0.2 = log([Cys-]/[HCys]) 100.2= Cys-/HCys Therefore, Cys-/HCys = 10-4Similarly, ...
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ORDER AN ESSAYHansch Analysis
Hansch analysis is used widely in the field of medicinal chemistry. It is the analysis that investigates the quantitative relationship and correlation between the compound’s biological activities with their physicochemical substituents. The global parameters considered in this method include the electronic, steric, hydrophobic, and other effects that use multiple correlation methodology (IUPAC). Application of the Hansch analysis includes the Quantitative Structure-Activity Relationship (QSAR). This application develops correlations between activity of the ligands and their properties. As a rule of the thumb, the Hansch model “gives information about the number of parameters to be selected for regression analysis in ...
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