Hypoxia Article Reviews Samples For Students

The article “Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics” discusses a new way in combating cancer cells, which is by targeting the enzyme carbonic anhydrase produced by these cancer cells. Carbonic anhydrase IX (CAIX) makes the production and growth of cancer cells favorable—first, it ensures that the intracellular pH is favorable for the growth of tumor cells then also makes the extracellular space acidic so that the tumor cells can spread more quickly. Therefore, interfering with or inhibiting the production of the CAIX enzyme can result in stopping the growth of the cancer cells themselves. ...

The pressure of atmospheric oxygen decreases gradually as barometric pressure drops with increasing altitude. The ability to perform work, such as walking and climbing belittles with the decreased availability of oxygen in the atmosphere for aerobic respiration. The Mount Everest is the highest peak on the earth with an altitude of 8848 meters. At such a higher altitude, the partial pressure of inspired oxygen or PIO2 reaches the limit at which humans can maintain body functions, such as cognition and ambulation. In 1953, Hillary and Tenzing used supplemental oxygen while climbing the Everest. It was only 25 years later that ...

This study aimed at characterizing the regulation of oxygen-sensing pathway in human mesenchymal stem cells (hMSCs). Cells were extracted from umbilical cord blood (UCB), adult bone marrow, and pediatric bone marrow. Expression of HIF-1a and PHDs in the three cells were determined under hypoxia and normoxia. The following activities were performed while conducting the study: cell culture and osteoinduction, characterization of hMSCs using flow cytometric method, hypoxic exposure and Western blot analysis, Quantitative Real -Time RT-PCR (Q-PCR), Glucose and Lactate Assays, Transmission Electron Microscopy (TEM), Determination of pH of the culture media, and Statistical Analyses.
The results showed ...