The activity of AMPK supports the normal function of the endothelial barrier (Xing, Wang, Coughlan, Viollet, Moriasi, & Zou, 2013), while on the other hand, the exposure of LPS ensures that there is inhibition of AMPK, thus accentuating lung injury and endothelial barrier dysfunction (Kratzer et al., 2012). It is a fact that LPS increases the permeability of the endothelium, which occurs once there is a decrease in the AMPK activity. This is consistent with the fact that the activation of AMPK activator, AICAR, emphasizes LP, once it is applied in vitro to test the hyper endothelial permeability. Experiments done ...
Essays on Neutrophils
3 samples on this topic
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Introduction
Research in lung cancer treatment can save lives and improve a patient’s quality of life. There are three main types of lung cancer: Non-small cell, small cell, and lung carcinoid cancer. Non-small cell lung cancer, such as Squamous cell carcinoma, adenocarcinoma, and large cell carcinoma make up about 85% of all lung cancers (Molina, Yang, Cassivi, Schild, & Adjei, 2008). Both environmental and genetic factors are significant in the cause of lung cancer. Chronic exposure to carcinogens, ionizing radiation, and viral infections can lead to alterations of the DNA in tissue lining the bronchial epithelium of the lungs. Furthermore, ...
Infection in cancer patient with febrile neutropenia: epidemiology, microbiology and management
Abstract Febrile neutropenia (FN) is characterised by a decrease in neutrophils number to values below 500 cells/ mm3 and an occurrence of fever higher or similar to 38.3ºC. It commonly occurs in cancer patients as a result of chemotherapy regimens. Chemotherapy destroys carcinogenic cells but also attacks in many cases some normal cells including essential elements of the immune system. Fever is one of the characteristic symptoms of FN and is usually associated with the presence of an infection caused by various microorganisms. Bacteria, including Gram-positive isolates (currently dominating) and Gram-negative species (dominant in the 1970s), are usually ...
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