Essays on Endothelial

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Introduction Cirrhosis is caused by liver injury that results in fibrogenesis and inflammation. These problems result in collapse of liver structures and significant distortion of hepatic vascular structure. This distortion leads to elevated resistance to portal blood flow as well as portal hypertension. Moreover, hepatic synthetic dysfunction is also caused as a result of these problems. Clinically, liver cirrhosis is considered as an end-stage disease that could result in death until liver transplantation is performed (Tsochatzis, Bosch, & Burroughs, 2014). Liver cirrhosis is an important cause of morbidity and mortality in most of the developed countries. In ...

Rocky mountain spotted fever is tick-borne infection. In endemic areas, the prevalence of the diseases is 15 per 100,000 persons. The disease is characterized by sudden onset of fever and headache. It is caused by gram-negative intracellular bacteria Rickettsia rickettsii. The bacteria have a high predisposition for the endothelial cell. Actin protein polymerization in the cells is important for the spread of bacteria from one cell to another. (Raoult & Parola, 2007) The bacteria cause lymphohistiocytic vasculitis and necrosis of the infected cells. It typically takes 5-7 days from the day of tick bite to the onset of symptoms. ...

In this paper, the analysis of “Blood flow reprograms lymphatic vessels to blood vessels” is discussed and the highlighted part is supported with the help of evidence and other research studies. There are some common congenital diseases are discussed in this article indicating how genetic lineage tracing become a reason for a change in vessels. It is analyzed that replacement by blood endothelial cells is not a solution, and lymphatic endothelial cell reprogramming is supported with the help of researches and experiments (Chen, et al., 2012). According to the past researches, the vascular defect may result in a stroke ...

Qualitative research is relatively new to nursing research. Despite its being usually underused and undervalued, qualitative research is increasingly contributing to nursing knowledge (Hall, 2006). The purpose of this paper is to compare qualitative and quantitative research in order to examine their differences. The comparison will be done by examining an article using the qualitative method and two articles using the quantitative method. All articles are on the same topic, cystic fibrosis. All articles were published in well-known and reputable journals. The qualitative article is by Carpenter and Narsavage (2004) and the quantitative ones are by De Bias, et ...

Abstract

The literature defines hypertension as a medical condition experienced when the systolic blood pressure (BP) is equal or greater than 140 mm Hg or when the diastolic blood pressure is equal or greater than 90 mm Hg. Additionally, it offers a description of systematic, cellular, as well as molecular causes of hypertension. High blood pressure within the arteries is referred to as systemic hypertension (SH). The primary role of the systemic arteries is the transportation of oxygenated blood from the heart to the tissues of the body. The constriction of the arterioles (small arteries) is responsible for the high ...

Seminar: Inflammatory and Immune Mechanisms in Lymphatic Vascular Disease

The YouTube video presented by David Zawieja, talks about immune and inflammatory mechanisms that occur in Lymphatic Vascular diseases. The lymphatic system has a significant role in various essential mechanisms inside the body such as edema resolution, fluid and macromolecular homeostasis, inflammation and antigen trafficking. The primary of the Lymphatic function involves the transportation of Lymphatic substances from the interstitial spaces between the tissues via lymphatic capillary network and nodes that terminate into the venous blood inside the veins. The most significant segment of the lymphatic function is the flow of lymph through multiple nodes. The immune cells like ...

The activity of AMPK supports the normal function of the endothelial barrier (Xing, Wang, Coughlan, Viollet, Moriasi, & Zou, 2013), while on the other hand, the exposure of LPS ensures that there is inhibition of AMPK, thus accentuating lung injury and endothelial barrier dysfunction (Kratzer et al., 2012). It is a fact that LPS increases the permeability of the endothelium, which occurs once there is a decrease in the AMPK activity. This is consistent with the fact that the activation of AMPK activator, AICAR, emphasizes LP, once it is applied in vitro to test the hyper endothelial permeability. Experiments done ...

Hypertension, the chronic elevation of blood pressure, results in enhanced morbidity and mortality in the long run. However, researchers are not unanimous about the pathophysiology of hypertension. Studies over the years reveal that between 2 to 5 percent patients face elevated blood pressures because of underlying adrenal or renal disease. Rest of the patients, nonetheless, do not exhibit any clear and identifiable reason for the malady. This statistics has well persuaded medical practitioners and researchers to acknowledge the role of multiple factors that might play varying roles in different patients of hypertension. Some of the most researched factors include ...

Healthy behaviors play a key role in daily life. Yet, certain unhygienic practices tend to interfere with the health and induce a risk to the overall life. These practices could be high-fat diet, alcohol, and smoking. There is a need to know much about these. In such context, the present description deals with a topic “ What will kill you first, a smoking, a high-fat diet or alcohol?”.

Health -related risk factors:

A risk factor is any quality, trademark or presentation of a person that improves the probability of building up an ailment or damage. A few illustrations of the more vital danger elements ...

Introduction

The pathophysiology of atherosclerosis involves a series of complex events that can be likened to that of a chronic inflammatory process, which results in the development of an atherosclerotic plaque. The first step in the process involves injury to the endothelial cells of the artery that results in endothelial cell dysfunction. The activated endothelial cells attract vascular smooth muscle cells (VSMC) and leukocytes, which proliferate and accumulate in the walls of the artery (Seidman, Mitchell, & Stone, 2014). These cellular components lead to the formation of a large amount of connective tissue matrix. This is the ultimate end point in ...

Introduction and Overview

The Rhesus factor (Rh) refers to the red blood cell’s(RBC) surface antigen;the name Rhesus comes from the small Indian monkeys in which it was first discovered. Rh incompatibility,sometimes referred to as Rh disease, is a condition that occurs when a woman with the Rh-negative blood type is exposed to Rh- positive blood cells, leading to the development of Rh antibodies. This condition can have fatal outcomes including haemolytic disease of the foetus or newborn, autoimmune haemolytic anaemia and haemolytic transfusion reactions (HTRs). These conditions have, in the past, raised a lot of concerns, and some ...