Essays on Endothelium

Abstract

The literature defines hypertension as a medical condition experienced when the systolic blood pressure (BP) is equal or greater than 140 mm Hg or when the diastolic blood pressure is equal or greater than 90 mm Hg. Additionally, it offers a description of systematic, cellular, as well as molecular causes of hypertension. High blood pressure within the arteries is referred to as systemic hypertension (SH). The primary role of the systemic arteries is the transportation of oxygenated blood from the heart to the tissues of the body. The constriction of the arterioles (small arteries) is responsible for the high ...

Seminar: Inflammatory and Immune Mechanisms in Lymphatic Vascular Disease

The YouTube video presented by David Zawieja, talks about immune and inflammatory mechanisms that occur in Lymphatic Vascular diseases. The lymphatic system has a significant role in various essential mechanisms inside the body such as edema resolution, fluid and macromolecular homeostasis, inflammation and antigen trafficking. The primary of the Lymphatic function involves the transportation of Lymphatic substances from the interstitial spaces between the tissues via lymphatic capillary network and nodes that terminate into the venous blood inside the veins. The most significant segment of the lymphatic function is the flow of lymph through multiple nodes. The immune cells like ...

The activity of AMPK supports the normal function of the endothelial barrier (Xing, Wang, Coughlan, Viollet, Moriasi, & Zou, 2013), while on the other hand, the exposure of LPS ensures that there is inhibition of AMPK, thus accentuating lung injury and endothelial barrier dysfunction (Kratzer et al., 2012). It is a fact that LPS increases the permeability of the endothelium, which occurs once there is a decrease in the AMPK activity. This is consistent with the fact that the activation of AMPK activator, AICAR, emphasizes LP, once it is applied in vitro to test the hyper endothelial permeability. Experiments done ...

Biomolecules serve different functions in a cell. The three major classes of biomolecules in the cell are: proteins, nuclei acids and carbohydrates. These molecular structures serve nearly similar functions in most organisms. Though the function of protein in forming cell architecture, signaling and communication is well known, little is known about the role of carbohydrate in communication. Nevertheless, it goes un-denying that carbohydrates are indispensable for cellular communication and signaling, just like proteins and nucleic acids. The paper titled, Carbohydrates in Cell Recognition, by the authors Nathan Sharon and Halina Lis, is a good review that elucidates the significance ...

Acute coronary syndrome is an umbrella term for a group of clinical symptoms indicative of acute myocardial ischemia. These conditions include non-ST-segment elevation myocardial ischemia (NSTEMI), unstable angina, and ST-segment elevation myocardial infarction (STEMI). These conditions are high-risk manifestations of atherosclerosis in the coronary artery and significant causes of utilization of emergency services and hospitalization (Kumar and Cannon, 2009). STEMI causes 30% of all acute coronary syndromes in Australia (Harper and Lefkovits, 2010). This paper will describe the expected presentation, pathophysiology, ECG findings, pre-hospital management, and initial 24-hour management of STEMI in hospitals settings. These aspects will be described ...

Communication Skills (Laughter is the best medicine)

Humor in general is infectious and perhaps this explains why a glance at a laughing person may make one to laugh without asking the reason for the person’s behavior. The jingle of boisterous laughter is far more catching than any sniffle, cough, or sneeze. Upon the sharing of laughter people are bound together, moreover, happiness and intimacy also are also enhanced. Besides the domino effect of amusement and joy, laughter also triggers healthy bodily changes. Laughter and Humor strengthen a person’s immune system, diminish pain, boost one’s energy, and protects from the detrimental effects of stress.

Shared laughter ...

The case of James a 48 year old male is a case of a patient with DVT but with little information. This man is a lawn tennis player with some issues that made him visit the emergency room and had the boot placed on him for 4 weeks duration. It was after that episode of medical management that he noticed a form of ankle to calf swelling on one of the legs. The swelling was really abnormal in terms of size hence he needs to see the doctor urgently. Despite swelling and the test such as ultrasound done, the extent of severity to him ...

Available empirical evidence and facts points to the direction that potassium is a critical component in the human body as a regulator of blood pressure. The above stems from surveys and data recorded over a cross-sectional spectrum of the human population to the effect that areas and regions that take less of potassium have a likelihood of suffering blood pressure-related complications. It is to say that people who take less of potassium have a higher prevalence and prospects of getting hypertension. This logic is true and possible since the ion present in Potassium are unique and provide some functions that aid in the regulation ...

Introduction

Cells are independent units of life. However, when a cell becomes part of an organism, it becomes part of a tissue and organ system. Cells in a tissue are joined to each other and to the extracellular matrix (ECM) by cell junctions. There are three kinds of cell junctions: Occluding junctions, anchoring junctions and communication junctions. Occluding junctions occur in the epithelium where the adjacent cells are so tightly sealed together that even small molecules cannot pass. Communicating junctions allow the exchange of chemical and electrical signals between cells. Anchoring junctions are the ones which attach a cell either to its neighbor or ...

Introduction

The simulated experiment of the practical is about the addition of agonists and antagonists on a guinea pig ileum and observing the effect of these agonists and antagonists on the ileum. This experiment is carried out with an aim to determine the effects of different concentrations of agonists and antagonists on the ileum of a guinea pig. In this experiment the type of data that are to be collected include the traces of acetycholine in the guinea pig ileum on addition of different concentrations of matropine. The expected values of the experiment are that the contraction of the ileum to change ...

Analytical methods to evaluate seed dormancy in legumes

Abstract Legumes are known to have multiple health benefits. The seed coat in particular contains a number of bioactive compounds which possess antioxidant activity. Of great interest is the relationship between the chemical composition of the seed coat and its role in seed dormancy. Modern technological approaches are currently used to further identify these compounds and determine their role in seed development; these include NRIS FTIR, mass spectroscopy, electron microscopy and chromatography. The following review describes the constituents of the legume seed coat and their respective roles in dormancy and other stages of seed development. The review also highlights ...