Essays on Inhibition

Introduction of Topic

Burden of Deep Vein Thrombosis Deep vein thrombosis is a severe preventable cause of morbidity-mortality around the globe. This disease is so silent hence difficult in diagnosing it and so it is seen as a significant challenge regarding diagnosis. The Little level of clinical suspicion and higher incidence and fatality makes deep vein thrombosis a grave concern to the world (Jaff, et al, 2011). In the United States, 1 to 2 in every 1,000 people is likely to be affect by deep vein thrombosis annually. There is also an estimation that up to 100,000 Americans scampers to ...

1. Biot’s respiration named after Camille Biot is an abnormal ataxic breathing pattern, where rapid series of shallow respiration are followed by a period of apnea. In order to known how AMP kinase, knock down leads to Biot respiration in mice; it is necessary to known how AMP kinase affects respiratory rate. AMP kinase is a metabolic sensor and is activated in response to stretching of the lung alveolar cells and other stressors. During respiration, the lung goes through cycles of expansion and contraction (Budinger et al., 2008). When the alveolar cells stretch during expansion, the 5′ AMP-activated ...

THE SCIENCE OF FOOD

Cancer and nutrition – good nutrition is very important in the management of cancer and thus healthy eating habits are encouraged during this period. Tumors that develop in the stomach or intestines may, however, affect the way the body uses the food that is ingested and may not absorb all the food, although the patient may be seen to be eating enough food. The side effects that may affect eating when one has cancer include vomiting, dry mouth, constipation, mouth sores, loss of appetite among others. Nutrition therapy is advised for cancer patients to help maintain a good quality life ...

3-nitrooxypropanol Report

Introduction Sheep, cattle, goats, and some wild animals such as antelopes and their families that are predominantly known as ruminants ferment plant material in their rumen. The result of this fermentation process is the formation of propionate, CO2, acetate, butyrate, and methane (Alexander et al., 2015). The carbon dioxide and methane formed escape from the bodies of these animals into the atmosphere.3-nitrooxypropanol is believed to inhibit methanogenesis in ruminant, an action that has various applications and benefits to the environment and animals. This report will consider the need for and application of the 3-nitrooxypropanol and how it would work ...

Disease pathophysiology

Definition of breast cancer Breast cancer is a malignant growth of cells in the breast. This type of cancer arises in the milk-producing glands when cells begin to divide in an uncontrolled way, forming a tumor. The most common neoplasm in breast cancer is the adenocarcinoma of the cells covering the terminal lobular unit (American Cancer Society, 2016; Stephan, 2016).

Prevalence of breast cancer

Breast cancer is the most common invasive cancer to affect women in North America, with more than 200,000 new cases each year, and worldwide, counting up more than 1,200,000. It is the second cause of cancer ...

Novel drug sourced from snake venom

Abstract The cardiovascular and cerebrovascular diseases have continued to be some of the leading death causes across the globe. In the recent times, the field of medicine has received substantial advancements, particularly in the areas of pharmacological treatment and the prevention of the disorders such as the plasminogen activators, platelets GPIIb/IIIa antagonists and the direct thrombin inhibitors. The development of the novel drug, the tirofiban sourced from the Echis carinatus venom been highly reported to be of great importance. Tirofiban, an anticoagulant factors isolated from Echis carinatus has a variety of immune responses that includes both acute inflammatory responses ...

Recent developments and current trends in human longevity

Age-related diseases and aging have become one of the greatest challenges with respect to financial burden and social status. Based on current evidence and a review of over 100 years of scientific experience, the concept of aging has received criticism owing to growing population of elderly and age-related diseases that act as a burden to the economy. An international workshop entitled, ‘Interventions to Slow Aging in Humans: Are We Ready?’ was conducted in Italy with an objective to provide a consensus on the discovery and development of safe interventions for aging in humans with the help of biologist and ...

Introduction

The large production of bisphenol A (BPA) in the world has been documented because of the increased usage of the same in various industries. The most critical industries that have been using this BPA include those manufacturing containers for foods and beverages, cigarette filters, thermal receipts as well as paper currency. With such a huge provision, it is critical that the basis of such developments only emanates from making the right choices over its uses because its production to a total of 2.7 million tons could be disastrous to the body. The main reasoning here is that the chemical ...

Question 1: Uses the correct term for chronically recurring seizures.

Answer: Epilepsy Question 2: Determines if the patient in the scenario has epilepsy. Answer: J.G. does not have epilepsy. She has only had three previous cases of seizures prior to which she had not experienced any seizures. The current cases were triggered by the cesarean section thus too early to refer to the condition as epilepsy (Ko, 2016).

Question 3: Identifies possible conditions, besides brain injury, that contributes to the lowered seizure threshold for the patient in the scenario.

Answer: Apart from brain injury, lowered seizure threshold can occur as a result of infectious illnesses such as AIDS, meningitis as well as developmental disorders such as neurofibromatosis and autism (Ko, 2016).

Question 4: Describes the pathophysiology of a seizure.

The brain and the nervous systems functions within a ...

Public disturbance is actions that violate public order or moral or other behaviour that is interpreted as a threat to the normal routine of life of the society. Examples of such crimes are prostitution, pornography, gambling, vagrancy, public drunkenness and drug use. Often these disorders are called “crimes without victims” because they are difficult to accurately identify the victims of violations (C. Bartol & A. Barol, 2016). Latest statistics show that almost 80% of crimes are committed while intoxicated. Public disturbance under the influence of alcohol unfortunately occurs quite often. Control over one's own behaviour is reduced; the person is ...

The activity of AMPK supports the normal function of the endothelial barrier (Xing, Wang, Coughlan, Viollet, Moriasi, & Zou, 2013), while on the other hand, the exposure of LPS ensures that there is inhibition of AMPK, thus accentuating lung injury and endothelial barrier dysfunction (Kratzer et al., 2012). It is a fact that LPS increases the permeability of the endothelium, which occurs once there is a decrease in the AMPK activity. This is consistent with the fact that the activation of AMPK activator, AICAR, emphasizes LP, once it is applied in vitro to test the hyper endothelial permeability. Experiments done ...

Introduction

The kinetic characteristics are important for the design of chemical engineering processes. They allow assessing the time required for the reaction and choosing the temperature range suitable for the reaction. The reaction path is observed by measurments the transmittance of the Crystal Violet solution that reacts with sodium hydroxide. The concentration, and the color of the solution changes with the reaction flow, and this is measured by the spectrophotometer.

The data are plotted as concentration - time and logarithm concentration time, and the reaction rate is:

Rate = [Crystal Violet] [Sodium Hydroxide]. Using the excess concentration of one of the reagents, the reaction rate with respect to the other reagent is found from logarithmic plot (Rahul & Chakrabarti ...

Abstract

Bipolar disorder is one of the various clinical disorders that affect millions of people worldwide. There is no known cause for the disorder though genetics and environment play a significant role in exacerbating it. This paper examines the journey of one Carrie Mathison, a CIA agent who suffers from bipolar disorder. Like other patients with bipolar disorder, Mathison experienced frequent maniac episodes. She also exhibited high-risk behaviors, which are characteristic of bipolar disorder patients. That behavior was evident in her lack of inhibition and excessive drinking. Mathison also exhibited psychotic behaviors, particularly when she saw herself as a heroine ...

Prediction of PCL-R Scores

Psychopathy is defined as a mental disorder that is normally characterised by an individual always carrying out his activities in a manner that is selfish and manipulative and they always lack remorse. In addition to this, they are always in most instances emotionally detached from the public in that, they are always anti-social and further have the callous-unemotional traits. It was further realised, that in cases that the an individual shows these traits, then he or she ends up not caring that much about the people around him or her.Over the years researchers have had in place various theses ...

1. The researchers studied how humans act in the case of emergency individually or in a group when they are exposed to the inaction of other people, who also witness the same emergency. Experiments were carried out to test the following hypotheses: Passive reactions of other witnesses, in this case, confederates, to an emergency situation will affect the behavior of an individual; therefore, he will be more unlikely to act than if he were the only witness of this emergency; According to the second hypothesis, if a group of naïve subject witnesses face an emergency situation, two factors ...

Black Cohosh

Black cohosh is also known as black snakeroot (as the name appeared in the U.S. Pharmacopoeia in the year 1820), bugwort, columbine-leaved leontice, tall bugbane, cordate rattle top, rattleroot, macrotys, papoose root, and battleweed. Its Latin name is Actaea racemosa or Cimicifuga racemosa. Macrotys actaeoides is also a synonym for the drug (Frostburg State University, frostburg.edu). It belongs to the Ranunculaceae (buttercup) family (Kinghorn A 2). The plant was first described in 1690 in Phytographia by Leonard Plukenet as Christopheriana facie. Later in 1751, it was named as Actaea racemosa by Linnaeus. However, the name was later changed into ...

What part of this dilemma should a counselor point out is Yelena’s responsibility to acknowledge and address?

The sexual disconnect between James and Yelena is essentially a consequence of an absence in open and honest communication between them about sex, particularly in expressing their specific needs in relation to sex, which is referred to in psychological literature as ‘sexual self-disclosure’ (Tang, Bensman, & Hatfield, 2013; Litzinger & Gordon, 2005) or ‘dyadic sexual communication’ (Pazmany, et al., 2014). Yelena had been enduring an unsatisfactory sex with her husband for more than two decades because she decided not to communicate her needs on the mistaken notion that doing so is being unfeminine. Yelena felt the dilemma between her need for ...

In the medical field, there are constant inventions that are intended to improve the quality of care for patients. These interventions are based on qualitative and quantitative research whose results indicate the effectiveness of the practice on different patients. Patients living with medical conditions like Diabetes rely on these practices to make their lives better. The adoption of the interventions is based on how well the medical professions understand it and how it changes the lives of their patients. The following is a detailed look at one of the practices and how I would ensure its adoption in a ...

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Diuretics targets to lower sodium and water reabsorption that may lead to enhanced water excretion. The main aim of diuretics is to reduce the fluid volume inside the body and maintain the electrolyte and water equilibrium. These agents are used for managing the pathological conditions including hypertension and edema such as cardiac congestion failure, liver and kidney problems, and glaucoma. It also helps in processing and regulating the blood pressure by eliminating the excessive salt from the body which slows down the cardiac muscles to impel the ...

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Introduction

Parkinson Disease (PD) is a very complicated neurodegenerative condition including the motor and non-motor manifestations that lead to neuronal loss. Currently, only symptomatic therapies are available but nothing is known yet to prevent this degenerative process. This is a multi-factorial condition with multiple risk factors that includes increasing age, genetic vulnerability, and environmental determinants. All these factors mutually play a role in the pathogenic process of PD. Medical sciences have achieved major advances in understanding the process working behind PD development that are Nigral Dopaminergic Apoptosis, Protein ...

The elevation or lowering of an individual’s mood can be attributed to one or more disorders that affect the psychological well-being of the affected person. Mood disorders can cause depression, anxiety, and generally create a personal environment for the affected individual that is difficult and even impossible at times to handle. Many people who suffer mood disorders seek therapy or medication, or both, to help get through each day. From a psychological standpoint mood disorders are a debilitating effect that can have a great impact on an individual’s life. There are several types of mood disorders, and ...

When a person wants to lose weight, he just wants to get rid of excess fat. However, in the reality it often turns out that the majority of modern diets and training methods cannot burn fat. The result is that people together with fat lose muscle mass.

The Role of the Thyroid Gland

Low thyroid hormone level often causes a general slowing of the metabolic rate, including the inhibition of processes of fuel utilization by muscles, lack of power, increased sensitivity to cold and catarrhal diseases. Today low-carbohydrate ketogenic diets have high popularity. People suffering from insulin resistance may gain an advantage from them by ...

Assignment 2

PART A - (Total 15 marks)

Cephalexin and Gentamicin The mechanism of action of amoxicillin is focused on the prevention of the synthesis of the bacteria’s cell wall through the binding and inhibiting of the cell wall transpeptidases (Katzung, Masters, and Trevor, 2012). Specifically, it attaches to the penicillin-binding protein 1A found in the cell wall of bacteria. Then, the agent disintegrates the lactam ring to allow the acylation of the penicillin-sensitive transpeptidase C-terminal domain. The formation of the cross-link of the linear peptidoglycan strands is prevented by the inactivation of transpeptidases. Since the third and last stage ...

The primary hypothesis of the study of “Group Inhibition of Bystander Intervention in Emergencies” was to see if people would see smoke filling the room as an immediate danger and help others by intervening during an emergency or if they would behave in a passive way whether there were others in a room or whether they were alone in a room. The independent variable in the “Group Inhibition of Bystander Intervention in Emergencies” was the people who were there along with the smoke filling the room. They were either there by themselves or in a group. The smoke filling ...

Summary: In the article titled, “Abnormal Cortex Plasticity in Juvenile Myoclonic Epilepsy”, the authors investigate the role of defective motor plasticity in the pathogenesis of Juvenile Myoclonic Epilepsy (Strigaro et al.). Prior to this study, JME was linked to motor cortex hyper-excitability and to the abnormal function of thalamic networks. This study, identifies a new mechanism that can cause JME, a common form of generalized epilepsy seen in children. The motor cortex plasticity was studied using an interesting technique called the Paired Associated Stimulation (PAS). The details of this technique are discussed in the methodology section. The role of ...

Summary: The study titled: “The Role of Prefrontal Inhibition in Regulating Fascial Expression of Pain.”, examines the role of pre frontal cortex in the control of fascial expression of pain (Karmann et al.). Expression of pain is determined by a certain factor in the environment (like the availability of caregiver) and also on factors that exist within an individual. Expressing pain is a form of communicating once feelings to others. Understanding expressions may help in assessing the pain in a patient (Craig). Presently, assessment of pain in an individual, is done based on the verbalization of pain by the ...

Introduction

The total number of patients with cancer keeps soaring globally with around 14 million cases diagnosed by 2014. Each year, about 8 million people die of cancer-related illnesses globally. There are quite some remedies that have been proposed to mitigate in the cancer menace. This study is focused on cancer treatment by curcumin through tyrosine kinase inhibition. Curcumin is the primary coloring agent found in turmeric, a tuber of the herb Curcuma longa Lin. It has widespread use as a flavoring agent (Aggarwal and Bokyung 87). It is also well known for its medicinal value commonly used to suppress ...

Temperament plays a significant role in the development of adjustments and social competence. The support for this theory emanates from a number of studies conducted in North America and Western Europe. However, most of the effects of temperament on development take place in the cultural context. Further, temperament makes a substantial contribution in the development of social functioning and peer relationships. I hold the opinion that temperament may play a significant role in influencing the behavior of people. However, the influence on behavior is likely to be constrained by the cultural and social context. For instance, a group of ...

Introduction

At an old age, multiple medical medicals are almost unavoidable. The wellness of the body reduces and several elements may contribute to the ill condition of the individual. The elderly need special care with proper medical interventions. Geriatrics is a specialty aiming at resolving medical issues for old people. It is significant in promoting prevention as well as treatment of diseases in older adults. The medical wellness for the elderly is affected by some factors. One of the most sensitive factors influencing the participation of older individuals in medication regimen is the irresponsiveness of the body to the drugs. ...

Patient information

The patient under review is a 42 year old female Indian who is admitted into the emergency room presenting with acute gastrointestinal bleeding. Prior patient diagnosis reveals the patient had suffered from dental abscess and also a fractured tooth, which was subsequently treated with antibiotics. However, a tooth extraction procedure was carried out for the extraction of the tooth. Ensuing dental ache was treated with drugs purchased over the counter (OTC) including ibuprofen and acetaminophen before the medical prescription of Vicoprofen. The patient complains of nausea and headache in addition to vomiting copious amounts of a dark brown liquid ...

Question 1

For succinate oxidation to fumarate there is yield of 2H+ and 2 electrons; however, the process of the reaction skips one step thereby leading to 2 ATP. The resulting FADH2 electrons skips the first stage of oxidative phosphorylation by moving into the electron transport chain located in CoQ. This can be illustrated as NADH -> CoQH2. Consequently, there is 2 ATP forming stages found in the electron chain from CoQ to O2 used in this course (Schwender et al, 50). Indifferent to the first scenario, oxidation of malate to produce oxaloacetate results to NADH, with production of 2H+ and ...

The human body consists of trillions of cells that work together synchronously for the maintenance of an organism. The metabolic needs of all the cells in the body are almost similar. For the well-being of a human body and the proper functioning of all the cells, constant internal environment needs to be maintained by providing the cells with oxygen and nutrients (Homeostasis and Regulation in the Human Body < OpenCurriculum, 2016) The internal environment of the body is tissue fluid, which bathes all cells making up the body (Mader, 2016). The composition of the tissue fluid must always remain ...

1. The molecule chosen for the analysis is Immunicillin -H. It is a transition state analogue for the enzyme purine nucleoside phosphorylase (PNP). Chemically Immunicillin -H is [(1S)-1-(9-deazahypozanthine-9yl)-1,4-dideoxy-1,4-imino-D-ribitol] (Kicska et al. 2001) 2. PNP is important for the degradation of nucleotides, especially deoxy guanosine. In the absence of this enzyme, deoxy guanosine accumulates and inhibits T cell function, causing T cell mediated immunosuppression. Inhibitors of PNP were found useful in treating T cell malignancies. Inhibiting PNP using transition state analogue, triggers apoptosis of T cells. Though Immunicillin-H inhibits stimulated malignant and nonmalignant T cells, ...

Immunogenic cell death: the role of SAGE

Immunogenic cell death: the role of SAGE

Introduction

Millions of cells are always being removed in the human body not only to regulate and coordinate the body’s biochemical pathways but also to keep the cells healthy. This particular systematic removal of cells occurs through a selective mechanism called cell death or apoptosis process. Apoptosis is not a new concept in the understanding of the biological workings of the body. This homeostatic death of body cells has been defined as a tolerogenic or a non-immunogenic event for many [1]. However, new discoveries have unearthed the existence of a different concept ...

In the process of wound healing, angiogenesis is also known as neovascularization. The process commences in lined with the proliferation of the fibroblast when the endothelial cells mover towards the wound site. Oxygen and other nutrients are required for the formation of epithelial cells and the activity of fibroblasts. In comparison to the fibroblast and epidermal mitigation, angiogenesis is crucial for other stages of wound healing. The process of angiogenesis is complex and occurs in the following stages: Latent period: In this stage, vasodilation and premeabilisation are known to permit leukocyte extravasation during the haemostatic and inflammatory phase. Decontamination ...

4.0 Discussion 4.1 Introduction The primary goal of the present study was to investigate how manipulating anxiety can impact cognitive performance during acute exercise bouts measuring four minutes per stage on an ergometer. The ergometer measures muscle power. Five stages of intensities were applied during the exercise trials under two conditions. The five intensities are listed below.

60% Heart Rate Response (HRR) 80% HRR Cool down Post 15 minutes The two experimental conditions refers to the two types of stimuli. congruent stimuli, and incongruent stimuli The research was built from previous studies carried out by Gratton, Coles, and Donchin ( ...

Question 1

FAD is reduced to FADH2 in Succinate oxidation to fumarate through catalytic action of succinate dehydrogenase. The resulting FADH2 electrons skips the first stage of oxidative phosphorylation by moving into the electron transport chain located in CoQ. This can be illustrated as NADH -> CoQH2. Consequently, there is 2 ATP forming stages found in the electron chain from CoQ to O2 used in this course (Schwender et al, 50). Indifferent to the first scenario, oxidation of malate to produce oxaloacetate results to NADH consequently, the NADH produced electrons completes its movement in 3 ATP forming steps associated with chain ...

Immunogenic Cell Death: The Role of RAGE

Introduction Millions of cells are always being removed in the human bodyin order to regulate biological pathways and keep cells healthy through a particular mechanism called cell death or apoptosis. Through apoptosis, such homeostatic death of cells has been defined as a tolerogenic or a non-immunogenic event for many years [1]. However, during the past few years, scientists have discovered the occurrence of a different concept of cell death – immunogenic cell death (ICD), where the death of a cell stimulates a response from the immune system against antigens of a dead cell, and this mechanism of cell death may ...

Biology

Analysis of Sources Lebrec, H., Ponce, R., Preston, B.D., Iles, J., Born, T.L. & Hooper, M. (2015). Tumor necrosis factor, tumor necrosis factor inhibition, and cancer risk. Current Medical Research and Opinion 31/3: 557-574. DOI: 10.1185/03007995.2015.1011778

This is a secondary source. Reasons are as follows: -

The research design is based on a literature review (Lebrec, Ponce, Preston, Iles, Born, & Hooper, 2015, p. 557). The researchers have carried out a topic search in the Ovid Database system (Lebrec, Ponce, Preston, Iles, Born, & Hooper, 2015, p. 559). The researchers have quoted work from Waters et. al, Grunhagen et. al. and Derorose et. al. to establish the efficacy of isolated limb perfusion ...

Introduction

Millions of cells are always being removed in the human body in order to regulate biological pathways and keep cells healthy through a particular mechanism called cell death or apoptosis. Through apoptosis, such homeostatic death of cells has been defined as a tolerogenic or a non-immunogenic event for many years [1]. However, during the past few years, scientists have discovered the occurrence of a different concept of cell death – immunogenic cell death (ICD), where the death of a cell stimulates a response from the immune system against antigens of a dead cell, and this mechanism of cell death may ...

Vascular System: The New Frontier in Cancer Research

Vascular System: The New Frontier in Cancer Research For the last 50 years, cancer treatment has been ruled by the fact that each type of tumor must be selected for specific cancer treatment. Thus, medics have concentrated in producing specific types of drugs for the treatment of certain types of cancer (1). The types of drugs used were specific to candidates affected. Nonetheless, cancer cells have high rate of mutation hence they are very unstable therefore some cells become resistant due to repeated drug use or exposure to chemotherapy. The high rate mutation causes the cells to be genetically ...

Disease management constitutes an important area in the clinical research where drugs possess a significant position. The effect of drugs on various organ systems has been the area of much research interest which gradually made feasible the development of several classes of drugs. Drugs may have dual role of promoting and inhibiting the vital biochemical and molecular pathways that play influential role in the disease outcome.

Angiotensin converting enzyme (ACE) inhibitors are considered as anticongestive heart failure and antihypertensive agents. They have gained wide spread physician and patient satisfaction. The ACE inhibitors prevent the ...

Full title- A COMPARISON OF THE INHIBITORY EFFECTS OF METAL IONS

Enzymes are an essential part for the functioning of the human system. Most of the enzymes require binding of metal ions and other non-protein components for their appropriate functioning. Such non proteins, which facilitate the functioning of enzymes, are called cofactors. The cofactors can be an organic cofactor as Thymine Pyrophosphate (TPP), Flavin Adenine Dinucleotide (FAD), Nicotinamide Adenine dinucleotide (NAD); or inorganic cofactors like metal ions, Mg2+, Cu2+, Mn2+, Zn2+ and Iron-sulphur clusters. When the enzyme is bound to a cofactor, ready to carry out its function, it is known as a ‘Holoenzyme.' An enzyme without a ...

Diabetes is a burning issue all over the world. World health organization has shown concerns on the prevalence and incidents of diabetes. In USA, 29.1 million people or 9.3% of the population; diagnosed or undiagnosed have diabetes. (CDC, 2012). As per National Diabetes Fact Sheet, 2011 215, 000 people in USA have type-I or type-II diabetes. Thus, diabetes is a disease penetrating all age groups. Treatment of diabetes has a few advancement in the recent past. Apart from general oral hypoglycemic agents and injectable insulin there are islet transplantation surgeries also available for diabetes. There is a wide scope of treatment of diabetes ...

SLIDE-1-4

WELCOME-SLIDE /ADDRESS My dear respected faculty member/teachers and fellows, Asslamualaikum /Good Morning/ Afternoon Oil & Gas industry and environment are much important for us, and we have to save it for ourselves and future generations. Environmental issues are on the increase at the world and it could affect the alternatives of corrosion prevention in the future. Ecological needs still to be developed; however, some elements have been established.

SLIDE # 2

SLIDE#3 Saudi Arabia geography mostly comprises of deserts & seas and its economy is much dependent on oil & Gas industry. We need to protect our industry for sustainable progress ...

Answers

- The differences between the cardiovascular diseases and the coronary heart diseases

The major differences between these two types of diseases relates to the vascular components of the cardiovascular system. This simply means that the cardiovascular diseases do not only involve the heart alone but also involves all the heart linked vessels. i.e all arteries, veins and lymphatics found to be associated with the heart and blood passes to and from the heart. However, the coronary heart diseases only relate to the vessels that are within the heart itself and supply the heart itself and also the muscles of ...

Glade Bender JL, Lee A, Reid JM, Baruchel S, Roberts T, Voss SD, Wu B, Ahern CH, Ingle AM, Harris P, Weigel BJ, Blaney SM. Phase I pharmacokinetic and pharmacodynamic study of pazopanib in children with soft tissue sarcoma and other refractory solid tumors: a children's oncology group phase I consortium report. J Clin Oncol. 2013 Aug 20;31(24):3034-43.

This study describes a phase I clinical trial of “Pazopanib” in pediatric patients suffering from soft tissue sarcoma (STS). Pazonapib is an anti-angiogenic drug. It is a competitive inhibitor of ATP molecule1,2. It competes with the ‘substrate’ ...

Microbial nutrition is essential in the survival and growth of microorganisms. Talaro and Chess considers several factors which are key players in the survivability of microbes in order to adapt or “inhabit all parts of the biosphere.” Among these factors include nutrients, temperature, pH, water availability, atmospheric gases, light, pressure and other organisms inhabiting the earth. Nutrition in essence is that which chemical substance in the form of nutrients are ingested inside the body such that when assimilated leads to the formation of energy to be used for metabolic activities.

Organisms require organic forming compound elements such as ...

_______________________

A Dissertation

The College of Graduate and Professional Studies ______________________ _______________________

Graduation or Proposal Month Year

(Keywords: cognitive booster, face naming, object naming cognitive psychology, lexical retrieval, semantic executive functions)

ACKNOWLEDGMENTS

ACKNOWLEDGMENTS ii

CHAPTER 1: INTRODUCTION 4

Overview of Problem 4 Problem Statement 9 Purpose of the Study 10 Research Questions and Objectives 10 Research Question 11 Objectives 11 Definition of Terms 12 Methodology 13 Significance of the Research 15

References 16

CHAPTER 1: INTRODUCTION An investigation was undertaken to try to identify an executive function that acts as a type of mechanism resulting in a “cognitive booster” (Oppenheim, Dell, & Schwartz 2010). The ...

Behavioral Finance Insights: Personal Finance and Planning

Behavioral finance is one of the new paradigms in the financial theory that aims at anticipating and comprehending the psychological financial decision making, especially of individual investors in conjunction with the systematic implications of the decisions in question on the financial market. Very simply, the basic premise of behavioral finance follows that individual investors or entrepreneurs tend to deviate from acting rationally in a utility-maximizing manner something that usually leads to business failures in the long-run. Essentially, behavioral finance does not substitute the existing theories on investment and finance. In other words, it complements and attempts to improve on their ...

Introduction

Prozac [fluoxetine hydrochloride] is commonly regarded as a first-line therapeutic medication for adolescents due to its supposedly better risk ratio than other antidepressants (Meeker, et al., 2015; Capitao, et al., 2015). It is also currently the most commonly used among selective serotonin reuptake inhibitor (SSRI) active ingredients, more than sertraline, escitalopram, venlafaxine (Wagner, 2015). However, its link to suicide cannot be ignored; or to birth defects and low libido (Naish, 2013). Despite the euphoria over it, a dampening cloud can be felt in the background. Is it worth risking adverse effects with Prozac? Is the risk for death or deteriorated ...

Video Game Violence and its effects on children

Abstract This was a single subject case study to evaluate the effects of video games on children. In this study, a case of 14- year- old boy was evaluated to check whether the problems he faced were the result of long- term exposure to video games. The 14- year- old boy was administered with sedatives and anticoagulants to treat deep vein thrombosis. He underwent FMRI scans, cognitive inhibition- counting test and emotional interference tests designed to see his brain activity and response to different stimulus. The FMRI scans and the results of the tests were recorded and compared with the ...

Abstract

Caffeine is a widely-used drug that modifies the psychological condition of the consumers. At high doses, it causes various caffeine-related symptoms such as agitation, as well as the restless legs syndrome. Since caffeine is a habit forming drug, it allows the development of tolerance and withdrawal symptoms. It also alters sleep patterns in accordance with the consumed daily caffeine dose. Although its arousal of the central nervous system can induce pleasant effects at relatively lower doses, caffeine can impair concentration and attention at increased doses. The present study, therefore, examines the various adverse effects of consuming caffeine at high doses. The ...

Introduction

Although drinking tea has been said to have health benefits for many centuries, only recently have its medicinal value been investigated empirically. There are four general categories of tea. These are green, black, white, and oolong tea. Black tea and green tea are the most common types. Black tea, which is obtained after fermentation and oxidation through fermentation, is the most commonly consumed kind. However, recent research indicates that some nutrients and elements are lost through oxidation. Green tea, which is the least unprocessed kind of tea, contains antioxidant polyphenols, especially the catechins believed to contribute to health benefits. ...

The science of sleep cannot boast of its significant age. In essence, the research of the brainwork by scientists continues only the last hundred years. Have you ever tried to do without sleep for a week or a month? Clearly, it is almost impossible. After some time, our brain is tired. The body starts to ache. People without sleep become irritable, lose the ability to think clearly and cannot concentrate. They need sleep - time to recuperate and stockpile for the next activity. People over 20 years out of 60 spends in a dream, and that is one third of all ...

Re-uptake involves the reabsorption of neurotransmitters by any of the neurotransmitter receptors or transporters. The transporters involved are usually of pre-synaptic neurons. Re-uptake occurs after the neurotransmitter has transmitted a neural impulse. Re-uptake is very crucial in order for the normal functioning of synapses to take place. This is because it allows the neurotransmitters to be recycled, thereby regulating their levels in the synapse. This in turn dictates the length of time it takes for a signal - generated by neurotransmitter release - to last. Neurotransmitters are usually large hydrophilic molecules that cannot pass through the neuronal membranes. For this reason, ...

- The stromal cells that are found in the developing gonads of tetrapods begin from the medulla from the peritoneal wall and the cortex from inter-renal blastema or mesonephric. Hence the gonads have a dual origin. - Spermatogenesis occurs in a syncytial complex because it involves the formation of sperm from undifferentiated cells that are first attached to rachis. Syncytial cell complex or syncytium result when cells with single nuclei fuse to for a cell with nucleus. Syncytial cell complex is vital in oogenesis in that it assists in the differentiation of cells. One other developmental model is vitellogenesis. - ...

Connective tissue growth factor induces collagen I expression in human lung fibroblasts through the Rac1/MLK3/JNK/AP-1 pathway

Many lung inflammatory diseases present pulmonary fibrosis as one of the symptoms, which is characterized by shortness of breath, chronic coughing and discomfort in the chest. It causes modifications of the lung tissues due to overgrowth, hardening and scarring. This occurs mainly due to deposition of collagen, an extracellular matrix (ECM) protein, whose turnover is regulated by fibroblast. Fibroblast is an important cell regulator that is enlisted by a site of injury. This process is driven by release of transforming growth factor-β (TGF-β), platelet-derived growth factor, interleukin-6 (IL-6), and IL-8/CXCL8. Previously, fibroblast was thought to express no or very ...

Discussion

Periostin, an ECM protein, was named because of its expression in the periodontal ligament and periosteum of adult mice.30 PN is expressed in tissue growth and remodeling, as in cardiac and valvular development and disease, wound repair, tumor tissues, and inflammation.31-37 PN is also widely expressed in various atherosclerotic vascular lesions: it could be located in the intima, preatheroma regions, and the extracellular matrix of advanced lesions with calcification. PN variants are associated with extent of atherosclerosis in young persons, which suggest the importance of PN in the development of atherosclerosis in the arterial wall.38,39 This study used ...

In life, human beings experience traumatic events; whether accidents, death or any other trauma, such occurrences harm the person’s psychological well-being. In some cases, people are unable to deal with the aftermath of such occurrences; they thus deals with it by pushing it out of consciousness into the sub-conscious. Instead of dealing with the problem, they ignore it through psychological processes; this research paper focuses on the analysis of the process. It is a process known as repression (Loftus, 1993). Repression is a very general concept in the field of psychology researched by many scholars through the years. Psychologists ...