Essays on Pathway

Introduction:

The function of many living organisms is coupled with a vast array of cells .These units in turn serve as role playing agents for the fundamental physiology that determines the well being of organisms. However, variations in cellular environment are thought to regulate cell growth, division and survival. A network of molecular pathways or signaling events are interlinked with the cellular functions .Alterations in this specific functional aspect could lead to unnecessary complications which may lead to health abnormalities. In such context , the present description is concerned with highlighting about mTOR Signaling in Carcinogenesis. mTOR stands for mammalian target ...

It was originally thought that basal ganglia were responsible for voluntary motor movements, and movement disorders were associated with pathological changes in the basal ganglia. However, it was found that the basal ganglia are associated with different cortexes with distinctive circuits, which are called loops, so a pathological transformation of tissue can manifest as a psychological or motor disorder, depending on the loop affected. The cortico-basal ganglia-thalamocortical loop is a one-way circuit that allows the basal ganglia to receive input from the cortex and send output via the thalamus back to different regions of the cortex. Pathological changes in this loop are ...

One of the key aspects of nursing is the focus on the society as the subject of the nursing career. The nurse has a role in ensuring that every member of the society can be assured of a healthy future and that their health problems today can be handled to achieve a positive outcome. It is the role of the nurse to seek any issue that relates to society health and seeking an amicable solution. When reflecting on a societal matter, it is always important that the nurse considers the role that group work plays in unearthing the potential health hazards in society ...

Introduction

Differential response is one of the alternative responses that have emerged as part of the child welfare larger movement. This movement strongly emphasizes on approaches that are strength based and family focused. The emergence of this alternative has been based on that there has been concern of the inability of the child maltreatment investigative response being cooperative and effective. Differential response has centrally been aimed ensuring implementation of child protection services (CPS) that can better be served through incorporation of collaborative and supportive approach, which does not involve stigma and constraints in the investigation (Hueber et al., 2009). This ...

Connective tissue growth factor induces collagen I expression in human lung fibroblasts through the Rac1/MLK3/JNK/AP-1 pathway

Many lung inflammatory diseases present pulmonary fibrosis as one of the symptoms, which is characterized by shortness of breath, chronic coughing and discomfort in the chest. It causes modifications of the lung tissues due to overgrowth, hardening and scarring. This occurs mainly due to deposition of collagen, an extracellular matrix (ECM) protein, whose turnover is regulated by fibroblast. Fibroblast is an important cell regulator that is enlisted by a site of injury. This process is driven by release of transforming growth factor-β (TGF-β), platelet-derived growth factor, interleukin-6 (IL-6), and IL-8/CXCL8. Previously, fibroblast was thought to express no or very ...

Background

Type II diabetes mellitus is a metabolic disorder found in adults that involves high blood sugar (hyperglycemia) due to insulin resistance as well as an insufficient amount of insulin. Type II diabetes differs from Type I diabetes, which is characterized by a complete lack of insulin. Symptoms of Type II diabetes include thirst, frequent urination and hunger. Long term complications include heart disease, strokes, vision problems and kidney failure. Today, there are close to 300 million people in the world who have been diagnosed with type II diabetes, an increase of 10 fold over the past 30 years. This increase in ...

Introduction:

Living organisms are equipped with robust machinery for executing a myriad of tasks to meet the day to day biological challenges. This machinery in turn relies on one or more interconnected pathways or networks composed of nucleic acid, proteins and other essential constituents. To say, it is the precise function of these components which determines the physiological well being organisms. Mammalian target of rapamycin (mTOR) kinases is one such known component that performs diverse physiological roles through its associations with the molecular machinery. mTOR is a protein that responds to metabolism and ageing, intercellular stress to growth regulation, growth factors ...

The epidermal growth factor belongs to the HER family receptor tyrosine kinases and it regulates cell differentiation and cell growth and interlinked with several human cancers. The signal transductions in the cells are controlled by EGFR. It is one of the oncogene which is involved in producing cancers via over expression of the ligands and the continuous activation and amplification of EGFR. The activity of the EGFR can be reduced by monoclonal antibodies against them. The activation of the EGFR is activated by binding of the transforming growth factor. The EGFR binds to receptor of HER family in order ...

Introduction

The Extracellular signal-regulated kinases (ERK) pathway is one of the most important signal transduction systems in a cell. This pathway regulates a lot of the fundamental processes of the cell including cell growth control and also cell death. The ERK pathway’s basic structure includes a couple of phosphorylations. The pathway provides a channel for the passing of signals from receptor that is located on the cell surface to the DNA inside the cell nucleus. The signal transduction process through the ERK pathway is a complex process. Initially, the signaling molecule, that is, the epidermal growth factor (EGF) usually binds itself to a receptor ...

The lung cancer is of primary concern among western population in the western world by virtue of exaggerated rate of smoker compared to non smokers. The pathology of lung cancer comprises of genomic instability resulting in abnormalities over a long span. The variations occur at gene level via process called as gene silencing mediated methylation; amplification of DNA, sequence changes in DNA along with looses and gains of whole chromosome. The genetic alterations observed in cell lung cancer contain a loss of regions which are in turn part of the genome especially chromosomes 9p and 3p and it is also observed ...

Embryonic stem cell is a crucial factor in the developmental process of a multicellular organism. Embryonic stem cells (ESCs) are derived at early stages during development and eventually give rise to all type of tissues and organs in an animal. The ES cell lines have three properties consisting of self-renewal, primary chimera formation and pluripotency [1]. Pluripotency, a key feature of ESCs, refers to the capacity of a cell to differentiate into several different types of tissues [2]. An array of cellular factors play important role in maintaining pluripotency and determining cell fate in the developmental pathway. Negative effects on these factors may ...

http://www.nlm.nih.gov/medlineplus/ 2. http://www.blackmores.com.au/products/joint-formula-with-glucosamine-chondroitin http://www.naturesway.com/ 3. Interaction between health supplements and prescription medication

Part A is answered for interaction between various agents

Fish oil and aspirin A clinical study was carried on 10 healthy patients to investigate the effect of omega 3 fatty acid prescription in combination with aspirin on the platelet aggregation effect and bleeding time. Aspirin alone inhibited platelet aggregation in presence of low concentration of collagen.Omega3 fatty acid treatment did not inhibit platelet aggregation under the experimental condition; however combination of aspirin and omega 3 fatty acid inhibited blood platelet aggregation. This study demonstrated the efficacy of prescribing omega-3 fatty acid (fish ...

The regulation of blood pressure and fluid homeostasis in the body occurs thorough an endocrine pathway called the renin angiotensin (RAS) pathway. This is a multistep pathway in which two step conversion of angiotensinogen to angiotensin I by rennin and subsequent conversion of angiotensin I to angiotensin II by angiotensin converting enzyme (ACE) occurs (Fig 1a). The RAS involves a number of peptides, receptors and enzymes partake in this highly regulated system. The angiotensin II, however, is the key biological player of this pathway. Uncontrolled activation and improper regulation of the RAS pathway leads to hypertension, organ failure and eventually death. ...

- Abstract Cardiovascular diseases such as heart failure are some of the leading causes of mortality and morbidity with Australia being one of the country’s most greatly affected (McLean, Esclick & Coats, 2006). An area of interest in the pathology of heart failure is the significance that polymorphisms of adrenergic receptor genes have on the outcomes of patients with heart failure. Single-nucleotide polymorphisms or SNPs that occur in the genes that encode for adrenergic receptors are known to have various physiological and functional consequences. Specifically, the β1-adrenergic receptors have a crucial role in the regulation of heart rate and ...

The glyoxylate refers to the anaplerotic pathway of the TCA (tricarboxylic acid) cycle, which enables growth in organisms using C2 compounds and bypassing the steps that generate carbon dioxide in the TCA cycle. The two unique enzymes that are used in this route are malate synthase and isocitrate lyase and malate synthase (Dunn, Ramírez-Trujillo, & Hernández-Lucas, 2009). Another notable difference between the glyoxylate cycle and the TCA cycle is that the glyoxylate cycle uses two molecules of acetyl CoA enter in every turn as compared to one acetyl CoA molecule used in the citric acid cycle. Just ...

When I was in eighth grade, my close friend Rick was diagnosed with a hole in his heart. After repeated attempts to repair it, his doctors just decided that he needed a new one. It took two years to find a donor, but Rick finally got a new heart. A year or two went by, and he started developing the same problem that he had before. His immune system was causing the hole which had by then grown so large that he needed another replacement. Another donor was quickly found, and he was back by the end of junior year. This time his ...

Cortisol is a steroid hormone synthesized in adrenal glands with a myriad of functions mainly in the endocrine and immune systems, and produced during stress circumstances. Under normal conditions, stimuli such as a pathogen release immune proteins called interleukins, which further activate T-lymphocyte cells. T-cells multiply to amplify the immune response and ultimately attack the pathogen (Abbas, 2014). Other immune responses are simultaneously activated, e.g. the complement system. The complement system exerts its functions through three pathways: classical, alternative or lectin pathways. The main activators of the classical pathway are antigen-antibody complexes, which trigger a series of events mainly mediated by complement proteins ...

Q1 Insolation can be described as the amount of energy of solar radiation received on a certain surface area and recorded in a given time. It is also known as solar irradiation and expressed as daily irradiation when recorded during a day and hourly irradiation when recorded during an hour. Throughout the year, the seasons undergo changes based on the quantity of sunlight hitting the Earth as it circles around the Sun. Seasons occur as a result of Earth tilting on its axis, moving in a loop around the Sun every year. Summer occurs when the hemisphere is angled towards the Sun ...

Bioinformatics combines the subjects of biology, mathematics and computer science in to a single field of study. There are various tools available for the biomedical researchers so that they are able to find out the desired biochemical, genomic and medical information. Search programs, data base storage and software programs are some types of bioinformatics tools that help in the analysis of proteomic and genomic data. The web based tutorial of bioinformatics programs will be used in this study to analyze the most important enzyme of fertilization called phospholipase C-gamma. This tutorial will use the bioinformatics tools easily acquired from the ...

Table of Contents

Executive Summary 3

Environmental Analysis 3 Market Need 4 Current Situation 5 Industry overview 5 Competitor analysis 5 Legal/Regulatory Overview 6 Target market 7 Target Audience Analysis 7 Marketing Objectives 8 Marketing Strategies 8 Product 8 Price 9 Place 9 Promotion 9 People 9 Physical layout 10 Process 10 Positioning 10 Marketing Tactics 10 Evaluation and Control ...

Introduction

Cilia are ancient and evolutionarily conserved organelles which are found on cell surface. This organelle project from those cell surfaces to provide multifunctional biological roles in the organism. An important role that cilia has been known to perform for cells are the locomotion, sensation and reproduction. The implication of the defect in the cilia is that the cell that tend to depend on the organelles for proper performance will be limited in it role. There are many diseases that have been found to be associated with cilia defects. Since cilia occurred as important organelles of many cells, majority of ...

1. Introduction: The current environment especially in Western societies promotes increasing consumption of calories along with a relatively sedentary lifestyle thus fueling the global obesity epidemic. Body weight is regulated by complex interaction of genes that promote energy storage along with environmental factors that promote enhanced energy intake and reduced energy expenditure. This obesity promoting environment makes it difficult for many people to sustain weight loss for long periods of time and adequately maintain healthy lifestyle habits. Obesity can overall have many devastating effects on human health such as increased tendency to develop high blood pressure, cardiovascular problems and strokes. ...

Introduction

Blood consists of erythrocytes and leucocytes suspended in it. Blood is pumped from the heart to the body through the arteries and it enters back in the heart through the veins. Blood without cells is known as plasma while serum is the straw colored liquid obtained after the removal of the clot. Plasma contains different proteins, nutrients and waste materials. There are different cases of blood disorders observed in humans.

Blood cells and platelets

The most abundant cells in the blood are the anucleate, biconcave erythrocytes. They contain a red pigment known as hemoglobin (Hb) that carries dioxygen (O2). Hb contains four subunits each ...

Sorting of the Receptor

Response to questions Q. A Describe the main pathway turned ‘on’ by the EGFR to regulate cell growth MAPK/ERK pathway is the main pathway, which is turned on by EGFR in order to regulate cell growth. This path comprises of a chain of proteins within the cell, which communicates a signal from the cell receptor surface to the DNA within the cell nucleus. When a molecule binds to the receptor at the cell surface, a signal is induced and ends when the DNA expresses a protein, which in turn produces some changes within the cell. One of the common changes are cell ...

(City, State)

Introduction

A balanced diet refers to the food intake, which incorporates all the dietary needs of an organism in the right proportions. This is unlike the adequate diet, which includes the energy that is sufficient energy for the need of an individual. A balanced diet, therefore, includes both sufficient energy as well as all the dietary requirements that are needed by an individual at the right proportion. The main components that make up a balanced diet include carbohydrate, proteins, vitamins, fats, dietary fiber, water and minerals. Carbohydrates as a source of nutrients in the body are usually broken down through ...

Personal transformation refers to a dynamic and uniquely individualized practice of increasing consciousness where individuals turn out to be critically knowledgeable of old, as well as new self-views, thereby choosing to integrate these opinions to a new self-definition (Campebell, 2004). Although these views might take the form of Transpersonal Psychology, Taoism, Contemplative Psychology or Confucianism, they are capable of distinctively conceiving the temperament of human existence thus transforming the individual differently (Campebell, 2004). As a result, this essay explores personal transformation through the various perspectives of Transpersonal Psychology, Taoism, Contemplative Psychology and Confucianism.

1) Transpersonal Psychology

Transpersonal psychology widens the theories of traditional psychology concerning ...

In spite of the significant advancement in science and technology, the science behind lifespan is still a mystery. The theories that explain the process of aging and life span, are broadly divided into programmed and error theories (Jin, 2010). Though none of these theories are completely satisfactory, they do help to enhance one’s understanding in the area. According to the programmed longevity theory, aging follows a biological timetable, which is innate and heritable. The theory was first suggested by August Weismann. He theorized that; there is an actual limit to the extent of somatic cell division in a species, and this is ...

Introduction

The immigration legislation in the U.S. today is the product of decades worth of political wrangling and public anger on both sides of the debate. The immigration debate has gone back and forth between the two political parties in this country to such a degree that there is de facto compromise on the elements of reform, and now all we have to do is implement the reforms that are already in place. The argument has gone back and forth for decades with both Democratic and Republican regimes signing legislation that encourages immigration then opposes immigration. The full circle is here ...

Breast cancer can be referred to as a cancer type that originates from breast tissue, mostly from the milk ducts’ inner lining or the lobules, which supply the ducts with milk (Sariego, 2010). Cancers arising from ducts are called ductal carcinomas, as those from lobules are called lobular carcinomas. Breast cancer affects humans, as well as other mammals. Breast cancer also affects in men. Breast cancer occurs due to an environmental factor’s interaction with a host that is genetically susceptible. Normal cells undergo division as many times as required and stop. They get attached to other cells where they ...

Abstract

Organ transplantation is an important life-saving procedure for those people, who have some problems in their organs. However, the problem of organ transplant rejection is an important issue in this case. In this problem, patient’s immune system starts rejecting the organ as a foreign body. This problem of rejection of the organ can be acute or become chronic. Several diagnostic procedures have also been developed to reduce the problem of rejection of an organ. Scientists have done a lot of research in this regard. Acute rejection needs immediate care. In order to reduce the problem, specialists will check the area ...

Abstract

Sexual addiction is a controversial topic that lacks substantial data. However, a psychosocial and neurotransmitter theories have been postulated in order to shade light on this disorder. Sexual addiction denotes sexual urges, thoughts or behaviors that appear out of an individual’s control or extreme in frequency; extreme addiction to sexuality (Kingston & Firestone, 2008). Addiction, on the other hand, denotes the state of behavior that goes beyond the boundaries of social norms and hinders a person’s ability to develop healthy relationships or function appropriately in life’s general aspects (Kingston & Firestone, 2008). In this paper, I provide theoretical explanations for John’ ...

Technology has led to efficiency in the health care industry. This technology continues to expand due to high investment in research and development in health care. As the technology improves, so will there be more job opportunities for practitioners. New careers will materialize as people handle technology in affecting the health care (Fett, 2006). Technology has given a major boost in quickly gathering medical records since they can rely on the computer system. The computer system enables the review of patients’ records and scheduling of appointments as well as administration of treatment. There have been significant innovations in the field ...

Introduction

The thyroid gland is an essential gland found in various vertebrates, and has thyroid follicles (comprised of thyroid epithelia cells), which are supplied by a dense network of blood capillaries. The thyroid tissue’s main function is the biosynthesis and secretion of the thyroid hormone, which is an essential biological molecule existing in either of two forms, T3 and T4. The activity of the thyroid gland is controlled through the neuroendocrine system, which involves the hypothalamus and the secretory actions of the pituitary gland. TSH plays a key role in stimulating the thyroxin-binding globulin (TGB) and the uptake of blood iodine ...

“Abstract”

Cholesterol plays a pivotal role in the fluidity of plasma membrane in cells. Evidence of cholesterol evolution from lanosterol suggests that cholesterol has little sensitivity to changes in temperature as opposed to lanosterol. Simulations also revealed that there is no ld-lo coexistence and 3-phase lines in lipid/lanosterol systems as opposed to lipid/cholesterol systems. The sterol also favors a strong interaction with lipids having saturated acyl chains (Miao et al.) which is a key factor in understanding and characterizing the lipid bilayer model. Based on surface potential measurements, cholesterol and ergosterol reduce the penetration of water into the lipid monolayer. Results revealed that excess ...

One of the promise Obama said would be on his agenda if re-elected was a “comprehensive” immigration reform bill that would both provide a pathway to citizens and also be fair to those who opted to try legal means to enter the US and are waiting in line to enter the United States. This month, the Senate kept good on this political promise by formally beginning debates on the matter. A bipartisan “Gang of 8” have come up with a plan, which creates a “13-year path to citizenship for most of America’s 11 million undocumented immigrants.” (CNN.com). The bill contains four ...

Environmental and Nutritional Requirements of Lactobacillus casei

Lactobacillus species have attracted considerable attention during the past few years due to the health benefits to the gastrointestinal tract when they are added as probiotics to food products such as yogurt and other fermented milk drinks (Broadbent, Larsen, Deibel, & Steele, 2010). In general, Lactobacillus species exhibit very complex nutritional and environmental requirements for optimal growth. Particularly, Lactobacillus casei is a rod shaped, aciduric (prefers acidic environments), facultative (capable of living in aerobic or anaerobic conditions) and mesophilic (temperature range between 15-40°C) lactic acid bacterium. These characteristics allow its isolation from different environments including fermented milk, meat or vegetable ...

How an Animal Cell Survives

Although the animal cell is similar in many ways to eukaryotic as well as some few eukaryotic cells, there are strikingly large differences between them, especially the requirements for survival in various environments (Baitsell, 2008). The animal cell is one of the members of eukaryotic cell category, whose structure is quite complicated by the organelles present as well as the diverse functions they play towards the survival of the cell and the organism in general (Solomon, Berg, & Martin, 2004). The cell structure is defined by a plasma membrane that bounds a number of organelles, all of which function towards the ...

Arguably, the food we eat in our entire life are imperative to long term stability, as well as health. The most important people who should give more focus nutrition and diet are children due to their continuous and active growth and development. In fact, losing weight and growing thinner is the global trend that media focuses on. This influence has tremendously been reflected on the eating habits of people. The argument in this case is that vegetarianism is a pathway of developing serious eating disorders, especially by focusing on vegetarians’ psychological and physiological health, as well as the reasons behind ...

1) What does the toll of two decades (1980-2002) of climate-related disasters tell us about vulnerability and inequality at the global level? (Chapter 3) The inequality at the global scale is very obvious when it comes to the degree of adverse effects that climate-related disasters cause. Accordingly, wealthy nations suffer relatively at a lower level compared to poor or developing nations. The reason behind this is the inability of the latter to respond to such natural calamities in a timely, efficient way. They basically, do not have enough resources to mitigate the damaged done by natural calamities. Timely and sufficient ...

Part 1. Group development

The process of group creation and evolution cannot be viewed as the single-moment one. Common framework of group development, formulated by Tuckman (1965), involves four main stages of group development. In the first stage of the development of a group, group forming takes place. As team members usually do not know each other well, they tend to avoid discussing their perspectives on serious issues and concentrate on routine. Storming phase is associated with the growth of the team and is usually characterized with difficulties because misunderstandings and conflicts may arise. At norming phase, participants are aimed at the development of ...

Glade Bender JL, Lee A, Reid JM, Baruchel S, Roberts T, Voss SD, Wu B, Ahern CH, Ingle AM, Harris P, Weigel BJ, Blaney SM. Phase I pharmacokinetic and pharmacodynamic study of pazopanib in children with soft tissue sarcoma and other refractory solid tumors: a children's oncology group phase I consortium report. J Clin Oncol. 2013 Aug 20;31(24):3034-43.

This study describes a phase I clinical trial of “Pazopanib” in pediatric patients suffering from soft tissue sarcoma (STS). Pazonapib is an anti-angiogenic drug. It is a competitive inhibitor of ATP molecule1,2. It competes with the ‘substrate’ ...

Introduction

Diabetes mellitus is a serious metabolic disorder, with a complex of symptoms, such as hyperglycemia, as a result of dysfunction in producing of the insulin, its synthesis or secretion. (Stöppler, 2014). This disease may lead to serious complications. The major risk factors that raise the prevalence of diabetes are hypertension, obesity, pressed immune resistance to the infectious illnesses and even cancer. (Bilous, 2002.) Patients with diabetes are more probable to develop neuropathic vascular diseases (National Diabetes Education Program NDEP 2000). Self-management and educational programs for this group of people can greatly increase their level of life. (Department of Health, 2005). According ...

Color Signals in Human

For more than 20 years there has been confusion and contradiction about whether and how the visual system can examine the motion of pure color patterns that contain no luminance variety. Three new papers have reported proof that, given their force, color patterns match luminance designs in the motion related sensations and utilitarian attractive resonance imaging signals. They evoke in people, and in the neural signs they inspire in the motion region of cortex of acting monkeys. This key aspect of the most seasoned and the most modern of cognitive neuroscience strategies decisively reject the proposal that color signs ...

The surgeon’s assistant is also referred to as assistants-at-surgery. The category of specialists serve as the members of the surgical team. In most cases, the surgeon assistant performs various tasks under the instruction of the surgeons. Some of the simple tasks that the assistant-surgeons include exposing, the surgical site, making the foremost incisions(Clark,15). This essay intends to develop a conceptual framework of the basic attributes that help in defining an assistant surgeon. This essay will put more focus on the educational requirements to obtain the job, description of the job and the role of technology in the ...

(Author)

Regulation of Xiap Protein in Breast Cancer Breast Cancer Breast cancer is the type of cancer that develops in the tissues of the breast. Two most commonly reported types of breast cancer are “ductal carcinoma” and “lobular carcinoma”. Ductal carcinoma is initiated in the lining of the milk ducts, which are thin tubes involved in carrying of milk from lobules of the breast to the nipple. Ductal carcinoma can be in the form of Invasive ductal carcinoma (IDC) as well as Ductal carcinoma in situ (DCIS). IDC is the most commonly found type of breast cancer ...

Introduction

The immunological disorders in an individual can occur due to three different reasons. This includes immunological diseases in an immunocompromised individual, or “autoimmune diseases”, or finally an immunological hypersensitivity that can lead to tissue damage.

Immunodeficiency diseases

Immunodeficiency diseases occur due to malfunctioning of the organs or cells in an individual. They are further classified as primary immunodeficiency (PID) and secondary immunodeficiency (SID).

Primary immunodeficiency disease

They occur when there is a direct defect in the immune system. They are further classified into eight groups depending upon the site of the defect. Combined T and B deficiencies. Severe Combined Immunodeficiency (SCID) is an excellent ...

Design principles

The ARM stands for Advanced RISC Machine which is the architecture that is used to build processors. One of the ARM architectures is ARMv6. The development of this architecture was due to the need to enhance the various constraints that have been of great concern for the development of the ARM architecture. The main issue of concern of the Next generation architectures has been the need to meet the needs of the market which keep on evolving. The different parameters like speed, performance, power, and cost should be the determining factors in the design and development of architectures. ARM ...

Purpose

Materials and Methods Gram Stain: the test was done to differentiate Gram-positive from Gram-negative organisms. A drop of the unknown 300 was suspended on a slide and the culture spread to an oven thin film. The culture was air dried and fixed over a gentle flame. Crystal violet stain was added over the culture and allowed to stand for 60 seconds. The stain was poured off and rinsed gently. Iodine solution was added on the smear, allowed to stand for 60 seconds and the stain poured off. The slide was rinsed with running water, and a few drops of decolorizer solution ...

Immunoglobulins (Ig) are also known as antibodies and they have molecular weights between 160000 and 970000 (Guyton, 2006, p. 443). They are key components of the vertebrate immune system and are a part of the humoral immune system, forming the base of the B-Cell. Igs function in cell-cell recognition as well as structural organization and regulation of musucle (Harpaz, Chothia, 2004). All Igs are made up of a light and a heavy polypeptide chain, usually two of each, but they may contain many more (Guyton, 2006, p. 443). They contain discrete domains of approximately 100 amino acids that are divided into categories ...

Abstract

A-kinase anchoring proteins (AKAPs) are a group of structurally varied scaffold proteins which are found to regulate the PKA pathway by localizing the protein kinase A and some specific enzymes at sub cellular level. So far several of the AKAPs have been found to play critical role in the regulation of phosphorylation of several PKA dependent substrates which are necessary for the modulating the cardiac function. Abnormalities in these AKAPs genes have been found to cause various forms of cardiac disease. The most prominent AKAPs are the AKAP9 and AKAP13. Mutations in the AKAP9 gene has been found to be ...

In a given ecological setting, some species dominate and influence the abundance of the other species in that ecology. Two pathways, which lead to dominance, exist: competition where the dominance species has superior access to the limited resources and low susceptibility to other processes that are not competitive. In the second pathway, the non-dominant species are normally very susceptible to the non-competitive processes. The former pathway is highly interactive and the dominant species suppresses its subordinates by limiting the resources available to them. Sustained dominance reduces the diversity of species that ecology. The second pathway is weakly interactive and the ...

Skeletal muscles are complex and highly specialized group of cells that are not isomorphic but can be categorized in a heterogeneous group with different qualities. This heterogeneity of the skeletal muscles is important because ensures different sets of functions that skeletal muscles perform in the human body. This heterogeneity also enables a significant ability of the human organism to adapt to different conditions in life (Pette and Staron 2000). In addition of this heterogeneity, skeletal muscles also posses the ability of plasticity. This means that muscle cells can evolve and adapt to different stimuli and change their characteristics (Tavi and Westerblad ...

Abstract

Renal cell carcinoma is a devastating disease that oftentimes results in a poor prognosis because there are few effective chemotherapeutic options. The renal carcinoma cell line 769-P is an ideal in vitro model for investigating novel drug treatments for renal cell carcinoma. Two drugs that may potentially reduce renal cell carcinoma proliferation are Actinomycin D and phorbol 12-myristate 13 acetate (PMA). Both of these drugs have been shown to inhibit cell proliferation in other in vitro models of cancer. This study examined the effects of Actinomycin D and PMA treatment on the proliferation of 769-P cells. Cell viability studies indicate that ...

The management of chronic diabetes self-care programs is mainly the responsibility of the patient. In primary care, nurses normally emphasize the prevention of complications and adherence to diabetes self management regimes. However, compliance to diabetes self-care programs is always a challenge for many diabetes patients. Diabetes self-management programs require patients to make many lifestyle and dietary changes. Diabetes patients need to be highly motivated to adopt and conform to the lifestyle changes in diabetes self-care programs (Perry & Collins, 2009). This paper describes the process of implementing a protocol for motivational interviewing for diabetes patients at Ben Taub Hospital in Houston, Texas. ...

Research review

The objectives of motivational interviewing are increasing the motivation of people for behavioral change, and strengthening people’s dedication to embrace change. This technique emphasizes collaboration instead of confrontation, Autonomy instead of authority and evocation over education while handling the behavioral change process in people (Burke et al, 2002). A very large and rapidly growing body of research has evaluated the effectiveness of motivational interviewing as a behavioral change strategy. Many randomized, Quality, Meta- analytic research studies into the effectiveness of motivational intervention have provided an evidence base that motivational interviewing is an effective behavioral change strategy. Many randomized ...

Assignment 2 (Modules 4-6)

Background information: The diagram below shows the activation of mTORC1 by growth factors as already encountered in workshop 5. The activity of mTORC1 is mainly controlled by the tuberous sclerosis complex, which consists of a heterodimer of tuberin (TSC2) and hamartin (TSC1). The known function of hamartin is to stabilise tuberin. Tuberin has GAP (GTPase activating activity) towards the G-protein Rheb. Rheb is active in its GTP-bound form and activates the mTOR kinase resulting in phosphorylation of S6Kinase (S6K) and consequently ribosomal protein S6, as well as 4EBP-1, resulting in protein synthesis and cell growth. Growth factor signalling results ...

"Are Protein-Protein interactions likely to be valid therapeutic targets for cancer therapy?" In her paper entitled “Protein-Protein interactions and cancer: small molecules going in for the kill” Michelle Arkin raises questions regarding the grooved and linear regions that permit protein-protein bonds, the binding peptides also found in those regions, if those interfaces are tractable for small molecule discovery and what compounds might serve as bonding agents. Further investigation of compounds would include if they are active, inhibiting, and do they help further characterize the target. She documents tubulin and several others that have potential. Her conclusion confirms that ...

Congestive heart failure

Congestive heart failure is by caused by amongst other reasons heart failure occurring due to either or both systolic and diastolic ventricular dysfunction. The use of the term “congestive heart failure” is used to imply that the patient in question is having some form of fluid overload. Congestive heart failure is a major cause of morbidity and mortality accounting for a significant proportion of hospitalizations. Of further note is that its incidence increases with advancing age (Tansley, 2010, p.1396). Although the presenting signs and symptoms of CHF have remained the same over time, great advances have been made in terms of ...

Introduction

Key figures in the caliber of Ingo Potrykus have made alarming contributions in public health which have immensely impacted globalization and social change to the extent that remarkable shifts have occurred in the discipline both locally and in the international arena.

Major Contributions to Public Health

Ingo Potrykus is significantly known for developing the golden rice project which is exclusive to the production of provitamin A. Also Ingo Potrykhus was very influential in organizing funding for the project and teamed up with Peter Beyer in launching a $2.6 million venture.

Challenges of implementation

The first major challenge was identifying the target countries for the gold rice projects especially, ...

Hepatocellular carcinomas (HCC) exhibit genetic heterogeneity. Most of the HCC tumors are associated with activation of insulin/IGF-1/IRS-1/Ras/Raf/MAPK/Erk and a WNT/Frizzled receptors/β catenin signaling cascade which provides targets for therapy. All the pathways are mediated by genetic mutations and signaling compounds and the loss of regulatory proteins also contributes for tumor generation. Two signaling pathways are involved in the carcinogenesis which includes insulin/IGF 1/IRS 1/MAPK and Wnt/FZD/β catenin pathways. The insulin/IGF-1/IRS-1/MAPK cascade plays a crucial role in regulating regeneration of liver and embryonic development. The constitutive activation of these cascades which is due to IRS 1 over expression leads to HCC ...