Essays on Mice

It has never been a secret for people that physical activity stimulates the brain and provokes its development. Living in the modern world, it is hard to imagine our life without TV-shows, serials, computer games or Internet. It has become very complicated for us to devote our free time to something helpful, useful and effective. When talking about brain development and physical activity it is necessary to mention that scientists have devoted decades to the research of the fact that when we do sports, we stimulate our brain and improve our cognitive skills. It has been proved that exercising ...

Abstract

The impact of coffee (caffeine) on diabetes is an issue that has not found significant exploration in past literature. The general hypothesis and one that has been adopted in this study is that coffee and particularly it major ingredient caffeine has significant positive influence on prevention of diabetes in humans. In this experiment, the researchers utilized a sample of eleven mice that had a genetic mutation for becoming diabetic. These mice were subjected to a diet of water (control group) and diluted coffee in the experimental group (Yamauchi et al., 2010). It was assumed that the experimental group would ...

The definition and summary of what is and should be allowed for when it comes to animals and their confinement and purpose is up for debate. There are people that feel that any treatment of animals is all well and good due to their lesser status as compared to humans. There are others that suggest that animals should have as many rights as humans and that they should be given equal status. Of course, the more reasonable answer is somewhere in between those two extremes given that non-human animals are clearly not on the same level as humans. At ...

Introduction

The “Scientific Method” characterizes science from other fields of studies. It encompasses methodologies of scientific inquiry that follow certain patterns to easily obtain and make experimentation easier. The scientific method is improved as science and technology progress but it has the following general parts that are universal: a. identifying the problem statement, b. formulation of hypotheses, c. observation from sampling, measurement and description of the data obtained, d. formulation of inductions, e., employing theories and finally, f. formation of conclusion (Oxford University Press). These steps are greatly relevant to obtain the desired data for an experiment and with the ...

Introduction

The Scientific method is a framework followed by scientist in investigating a certain inquiry or process. Scientific method is a series of steps that was established during 1619 by Rene Descartes. This then led to the improvement of the principle so as being used until the recent times as a principle that guides every scientific fields (McLelland, n.d.). With scientific method, biases from personal prerogatives and the influence of environmental and social concerns are eradicated. The scientific method employs the utilization of testing procedures to verify claims that can be reproduced to strengthen the credibility. Scientific method is a ...

1. Biot’s respiration named after Camille Biot is an abnormal ataxic breathing pattern, where rapid series of shallow respiration are followed by a period of apnea. In order to known how AMP kinase, knock down leads to Biot respiration in mice; it is necessary to known how AMP kinase affects respiratory rate. AMP kinase is a metabolic sensor and is activated in response to stretching of the lung alveolar cells and other stressors. During respiration, the lung goes through cycles of expansion and contraction (Budinger et al., 2008). When the alveolar cells stretch during expansion, the 5′ AMP-activated ...

George from Of Mice and Men

Great Starter Of Mice and Men is a narrative regarding immigrant workers, Lennie and George. Lennie has a mental disability and has to rely on George’s guidance. He reckons that his life would be so much easier if he did not have to look after Lennie. George has taken advantage of Lennie’s disability to mistreat him, but his perception has changed.

Thesis Statement

Although George has become more understanding of Lennie’s condition, he is aware that the world is designed to prey on the weak as depicted by his previous interactions with Lennie.

Body Paragraph # 1

Adjective # 1 – Responsible Example George ...

In global societies, discussions concerning the use of animals in medical tests for research are uncomfortable and controversial. Modern technology often broadcasts horrific photos of procedures being conducted on helpless creatures accompanied by claims of untrustworthy results and skewed statistics. In the long run, animals will continue to be used for testing in laboratories until the value of the practice is diminished. “The benefits of animal research have been enormous and it would have severe consequences for public health and medical research if it were abandoned “ (Festing and Wilkinson, n.p.). This paper will present information regarding whether animal testing ...

Evaluate And Analyze The Paper I.E. Any Improvements, Why Things were done In the Relative Manner Cibely, O., Olivan, M., Jochen Springer, S. B., Tshiner, A., Figueras, M., & Toledo, M. (2012). Theophylline is able to partially revert cachexia in tumour bearing rats. Nutrition and metabolism.

Introduction/background

Explain the background to the research and how it came to being, name any previous articles used as the basis and explain why they are important, is the article building on previous work or aiming to resolve disagreements in previous studies, state the hypothesis being tested, what is the importance of the research question?

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Prior to the Great Depression policy makers in the United States generally tended to accept that business cycles happened and in accord with Adam Smith's "invisible hand," tended to be self-correcting. The stock market crash of 1929, and the more general problem of massive unemployment forced a reconsideration. Smiley (2008) and Bernstein (2016) both point out that the human face of the Depression left no choice but for some government intervention. Jahan and Papageorgiou (2014), discussing Keynesian Economics put it plainly: “The central tenet of this school of thought is that government intervention can stabilize the economy.” The centerpiece ...

According to Squire (2009), the altered respiratory pattern in AMPK KO neonatal mice has attracted a lot of scientific approaches to reach out to traditional answers. Knockout mice and transgenic models have however come up with relativity pyramids, which have been efficient enough in explaining why AMPK KO neonatal exhibit altered respiratory patterns(Bertoldo, et al., 2009). This paper bases its assertions on relevant literature to depict the how AMPK, out of its function as a fuel gauge, plays a critical role in the control of respiratory patterns in neonatal mice. AMPK protein kinase is a proposed energy regulator. ...

The article at hand discussed the effectiveness and benefits of usage of MR Imaging in the case of Alzheimer Disease. The study took place in a mouse model, however it claims for being equally effective in the treatment of people who suffer from this disease. The main purpose of the study was to determine whether MR targeted to the hippocampus is helpful in identifying and monitoring Alzheimer Disease. It is also aimed at seeking ways to achieve improvement in pathologic brain abnormalities and behavior that can possibly prevent prompt development of disease. The choice of the method that was ...

Answer Questions

Answer Questions.

Dietary factors (an unhealthy diet). Lifestyle (A sedentary lifestyle). Genes (familial predisposition) (Wallis, 2014). List four things that bacteria in our digestive system do to help us. Digestion of plant fibers. Influencing the storage of fat. Influencing blood glucose levels. Influencing response to hormones related to hunger (Wallis, 2014). Of the four things you have listed above (answers 4-7) which is the best documented, the best understood scientifically? The most understood and documented of the four activities is the digestion of plant fibers since bacteria have been found to digest organic materials both in vivo and in-vitro.

What are the two locations in the body that hold the most bacteria?

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The activity of AMPK supports the normal function of the endothelial barrier (Xing, Wang, Coughlan, Viollet, Moriasi, & Zou, 2013), while on the other hand, the exposure of LPS ensures that there is inhibition of AMPK, thus accentuating lung injury and endothelial barrier dysfunction (Kratzer et al., 2012). It is a fact that LPS increases the permeability of the endothelium, which occurs once there is a decrease in the AMPK activity. This is consistent with the fact that the activation of AMPK activator, AICAR, emphasizes LP, once it is applied in vitro to test the hyper endothelial permeability. Experiments done ...

Smoking electronic cigarettes (or e-cigarettes), colloquially known as vaping, has become a rapid global trend. In fact, about a fifth of Americans aged 25 to 44 are using e-cigarettes (Hwang et al. 667). E-cigarettes are battery-powered devices that use a solution of nicotine, flavorings, and humectants, to produce an aerosol, which will be inhaled by the user. The popularity of smoking e-cigarettes may be due to various motivations, but the most practical reasons are to help the user quit traditional cigarette smoking and to allow the user to use nicotine within non-smoking areas (Kalkhoran & Glantz 1). However, the popularity ...

Mechanical ventilation (MV) causes oxidative stress that is responsible for adverse consequences on organs. In a situation of MV, the excessive pressure impairs the function of the mitochondrial respiratory chain leading to oxidative and nitrosative stress (Kavazis, 2009; Hafner et al., 2014). MV is commonly associated with hyperoxia where an excess of oxygen is provided. In such a case an oxidative stress can be induced when the oxygen pressure in the alveolar exceeds that of the normal breathing conditions because the biological system is not able to readily detoxify the environment from components such as reactive oxygen species (ROS) ( ...

Introduction

The treatment for multitudes of diseases and disorders resulting from genetic reasons have been ambiguous since long as the only cure could be the correction of genes and DNA in the specific region. Gene therapy gave a promising horizon to the correction of such genetic defects whereby molecular tools are applied to reverse the mutation or any other changes in the DNA. The advancing biomedical research have offered several tools for gene therapy since last few decades that have been able to perform the desired roles but with one or the other limitations. Lately, CRISPR-Cas9 based tools for gene ...

Abstract

This paper is about the investigation of Parkinson’s disease, and in particular is involved with the examination of its symptoms, stages, causes, prevalence, diagnosis and treatment, and social impacts. Finally, the paper analyzes and evaluates two ongoing on Parkinson’s disease researches, which are also examined in respect to their impact on Parkinson’s disease patients. Key words: Parkinson disease, Parkinson disease causes and impacts, Parkinson disease symptoms and prevalence, Parkinson disease diagnosis, and Parkinson disease ongoing research.

Idiopathic Parkinson disease (PD) is a progressively evolving disease with main manifestations resting tremor, muscle stiffness, slow movement and loss ...

Industry Case Study Report

Industry Case Study Report

Abstract

The world has become increasingly mobile or that is what the statistics shows us. The number of tourists across the world has been rising all through the years barring a few occasions like post 9/11 in 2001 and during the global recession period of 2008-2010. The latest data shows that the international tourist arrivals have increased by 4 % to reach a record 1.2 billion tourist arrivals in 2015 . Almost all the major markets exhibited positive results and is it is expected to upkeep the momentum in 2016 as well. New Zealand also continued to show ...

Vladek's Mental Illness in Art Spiegelman's Maus

In recent years, a lot of comics are very mediocre, quite often they have similar super-heroes and antagonists. Not many comics evoke some powerful emotions, not many of them have a strong sense of compassion for the characters. They shock the readers very rarely. One of the graphic novels, which cause such a feeling, is "Maus." This is a comic of Art Spiegelman. He used the stories of this father. This is the book about the life of one family, about the survival of the mind and body in conditions where the word "destruction" is not an abstraction, but ...

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Introduction

Genome imprinting is the latest technique that has genetically modified the face of infertility; it is an epigenetic phenomenon through which the parental origin of a gene is determined based on its expression. 1 There are a vast number of genes in mammals that are marked with their parental origin, and the result of this phenomenon is a single parental allele. These marked genes are known as “imprinted.” They rely on the epigenetic machinery determining their parental identity and maintaining their origin-specific gene expression. There are 100 imprinted genes estimated in human and 200 ...

Mirna Salim

Introduction Cats have been living with us for thousands of years. As opposed to other domestic animals like cows and sheep that provide as with food and other raw materials, it has never been clear the main reason why human domesticated cats. Some schools of thought believe that cat was domesticated to help human eradicate rodents which were destroying crops. However, others believe that cats were domesticated just to be pets, to keep human company. This research will not major in the reason as to why cat was domesticated, but rather will focus on the origin of the domesticated ...

Relating Literature to Experience: Literary Masterpieces that Speak.

Literature has existed in our lives since the invention of formal standardized writing. Writers have used literature to express their thoughts and opinions on various subjects relating to human life. Fundamentally, literature has always been about relating to the human life and experiences. Literature employs elements of writing such a plot, point of view and dialogue to express the ideas of the author. In most cases, authors approach a subject by writing about experiences and using humor to pass the point across rather than approaching the subject head on. Literature has been used over time to record experiences and ...

American cartoonist Art Spiegelman’s Maus is considered a comic masterpiece and the two-volume telling the horrors of the Holocaust is a winner of Pulitzer Prize. Art’s father, Vladek was a Polish Jew, who survived the Holocaust. The essay looks at MAUS graphic novel, its artwork and how the author uses those images to tell a compelling story. Maus is considered to be as an intellectually substantive graphic novel. Spiegelman has depicted Germans as cats and Jews as mice and Germans and Poles as pigs cats in the graphic novel. The purpose is to show Germans as the ...

Introduction

Recently, worldwide obesity prevalence has been raised rapidly and nearly doubled between 1980 and 2014, however in 2014 more than a half a billion of adult (18 years and older) were obese (11% men and 15% women) (WHO, 2014). Obesity and overweight are defined as excess body fat accumulation that leads to health risks and comorbidities. Adult weight can be classified based on the Body Mass Index. Hence, an individual having a BMI equal to or more than 25 is regarded as being overweight, while a person with a BMI equal to or more than 30 is considered obese ( ...

Magnesium is an essential nutrient

Magnesium is a mineral which is of great abundance in the human body. Along with enzymes, it is important for protein synthesis, muscle regulation and a host of other important cellular factors such as oxidative phosporylation, energy production which involves production and utilization of ATP and glycolysis. Additionally, Magnesium is required to assist in different cellular processes such as DNA replication and transcription and RNA translation(Barbagallo, 2012). Magnesium is found usually in the bones and or in the soft tissues of humans. Next to Potassium, it is the most abundant ion in the body. The plasma actually contains ...

The article sins the father by Virginia Hughes is an epigenetic paper reporting the experiments carried out by Dr. Dias and Dr. Ressler of the University of Atlanta. The two doctors have studied the involvement of imprints in the process of inheritance in mice based on fear and the reaction associated to acetophenone. The doctors find a large than normal expression of M71 glomeruli receptors in the mice’s offspring’s noses. The amazing elegant but inconclusive cause effect approach bring a possible kind of an explanation to the controversial observation by the doctors and the scientific society to ...

Summary

Over the past few years, there has been a growing interest among neurosurgeons on the potential for therapies that impact on diseases, over and above the movement disorders and pain. One of the biggest targets of this increasing interest has been the nucleus accumbens. It has been studied for long, as an area of the brain that mediates a variety of behaviors, including reward and satisfaction (Salgado & Kaplitt, 2015). With this in mind, the modulation of the biology of the Nucleus Accumbens through either deep brain stimulation or through biological therapies like gene therapy or the transplantation of cells ...

4 – Nitroaniline

INTRODUCTION

4-Nitroaniline is an organic nitro aromatic compound. It is a yellow powder with a pungent odor and is highly soluble in hot water, methanol, ethanol, acetone etc (Lide 1994). Its chemical formula is C6H6N2O2. It has the following chemical structure: (Courtesy: PubChem 2016) It is also known as P-Amino nitrobenzene, P-Nitraniline or Benzene amine (PubChem 2016). It explodes on decomposition to emit toxic nitrogen oxides (Lewis 1996). 4-Nitroaniline is used in the manufacture of textile dyes such as the red azo dyes. It is also used in preparation of antioxidants, fuel additives, pesticides, pharmaceuticals and poultry medicines ( ...

Introduction

The total number of patients with cancer keeps soaring globally with around 14 million cases diagnosed by 2014. Each year, about 8 million people die of cancer-related illnesses globally. There are quite some remedies that have been proposed to mitigate in the cancer menace. This study is focused on cancer treatment by curcumin through tyrosine kinase inhibition. Curcumin is the primary coloring agent found in turmeric, a tuber of the herb Curcuma longa Lin. It has widespread use as a flavoring agent (Aggarwal and Bokyung 87). It is also well known for its medicinal value commonly used to suppress ...

Brief summary

Cocaine use disorder (CUD) is considered to be a health problem because of the millions of people who are using it worldwide. The article states that excessive cocaine use will cause changes in the prefrontal Cortes (PFC) (Terraneo, p.37). The reason for this is because PFC plays a significant role in the addictive cycle such as the inhibitory control, reinforcement learning as well as cravings. Many types of research that have been conducted show that the loss of inhibitory control is brought on by drug behaviors. The article looks at the animal studies that have been carried out in ...

ABSTRACT

Addiction is a serious problem in the modern era, in the United States and all over the world. Addictions can be to drugs and alcohol, but people can be addicted to many things. Many feel that addiction is the consequences for poor choices potentially encouraged by environmental factors. However, many argue that addiction is linked to genetics. The predisposition to addiction can be entirely hereditary. That means that some people carry genes that put them at greater risk for becoming an addict, which has been contributing to high addiction statistics. Today science has identified a number of genes that ...

Vitamin D deficiency during pregnancy: Effects, treatment and the outcomes

The aim of this study is to evaluate vitamin D deficiency in pregnant women and its impact on pregnancy course, the best way of management, and the outcome of this management Bone metabolism in humans is associated with a complex steroid hormone system which comprises of vitamin D (Harvey, et al. 2014). Many reports have suggested the potential benefits of vitamin D across therapeutic areas including vascular health, placental function, metabolism, and immune function (McAree, et al. 2013). Data based on biological and clinical findings suggest the key role of vitamin D in women reproductive health. However, there is ...

Summary of the article

Background and perspective Weaning refers to the gradual replacement of breastfeeding with other foods as well as different methods of nurturing. The weaning process is said to begin the minute the baby takes food from a source other than breast milk. This can be in the form of mashed bananas or formula from a bottle. From a medical point of view, it is important for babies to receive breast milk. It is recommended that for ideal and adequate nutrition, a child needs to be exclusively breastfed for the first six months. Medics also insist that nursing of a baby ...

Summary

The neural network controls physical activities. Recently scientists have found out that the neural network can be observed to show different levels of activation depending on an organism’s mental activity. Scientists have gone further to devise actual methods that detect brain activity in particular instances. The brain and the neural network never stop working; however, certain tasks cause the brain and the neural network to work faster, harder and more intensely (Garcia). These unique activities usually register or appear as spikes or dips in the never-ending sequence of brain activity. Genetically Encoded Voltage Indicators (GEVIs) are a promising ...