Gene Expression and Signaling Class
Short Answer Different Phenotype in PTEN Mutations While PTEN is either mutated or lost in both spontaneous and heritable cancers, the p110 alpha is frequently mutated in major forms of cancer such as breast cancer, endometrial, colorectal, ovarian, and prostate cancers with a greater prevalence of breast cancers (Nagata et al., 2004). Besides, the monoallelic loss of PTEN mostly contributes to the growth of tumor in the context of other somatic mutations in which case the count of PTEN proteins correlates with the severity of cancer, an indication that PTEN is haploinsufficient in functionality. Additionally, while the gene encodes ...
