Stem cells are undifferentiated biological cells that can differentiate into specialized cells and further divide through the process of mitosis to produce more cells. Stem cells are found in multicellular organisms; however, in mammals there are two broad categories adult stem cells that are found in diverse tissues, and embryonic stem cells that are isolated from the inner cell mass of the blastocyst. Stem cells and progenitor cells act as a system that repairs the body in case it is injured as well as replenishing tissues (Humber 105). However, in the developing embryo stems cells differentiate into specialized cells that ...
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The article under study is Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model.
Glioblastoma is referred to as the most cancerous type of astrocytic gliomas and the most commonly occurring chief brain cancer in adults. Due to the weak prognosis of glioblastoma, there is an urgent need for a better and profound understanding of disease pathogenesis. The article presents a demonstration of the fact that p53 deficiency is capable of cooperating with various mitogenic signalling pathways for inducing malignant glioma. As an example, it is not necessary to deactivate the ...
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