Essays on Mutant

In 1872, the 22-year-old George Huntington presented a paper describing an elaborately outlined inheritance pattern of a disease, which during the time was referred to as "chorea." In his paper, which was presented at the Meigs and Mason Academy of Medicine at Ohio, George described all the features of the adult-onset form of the disorder and outlined the disease’s autosomal-dominant pattern of inheritance. Although the mechanism underlying the inheritance pattern of the disease was not understood until the rediscovery of Mendel’s works, his paper was so comprehensive that George Huntington quickly became widely acclaimed. In fact, he ...

Vid30 complex participation in the degradation of CDC25 in yeast and their role in Ras/ cAMP/ PKA pathway

Background: Unicellular organisms such as Saccharomyces cerevisiae in its total life cycle is exposed to diverse and changing nutrient conditions. Thus, in order to survive and achieve a competitive advantage, it has adapted itself such that it not only uses the wide range of available nutrient sources but also the sources that are nutrient rich. It mainly uses fructose and glucose by rapidly fermenting to alcohol. In response to these nutrient conditions, the intracellular trafficking transcription and turnover of protein from nutrient transporters (e.g. Hxts) get regulated. Therefore, when the availability of the glucose increases, the expression of low- ...

We live in a world where there is good and evil. Since time immemorial, stories told by humans have always had heroes and villains. Human culture has always been rife with tales of heroism, both real and fictional, wherein awe-inspiring individuals faced immense adversity only to overcome it and accomplish good in the end. In the last century, these stories have taken a new turn in introducing fictional characters that are superhuman. The heroes in such storylines who’re more commonly referred to as superheroes are capable of feats that, by any standard, far exceed human capabilities. It is ...

Abstract

Cancer of the lungs is among the leading causes of cancer in the world. It has two forms; small cell lung cancer (SCLC), and non-small-cell lung cancer (NSCLC). NSCLC constitutes about 85% of cases of lung cancer. Epidermal growth factor receptor (EGFR) and its mutations are found to have an important role in this cancer. Therefore, EGFR tyrosine kinase inhibitors (TKIs) can work effectively against NSCLC. Gefitinib, which is a first generation TKI, and afatinib, which is a second-generation TKI, are effective as a first-line therapy for advanced NSCLC. Erlotinib is effective as a second-line therapy for advanced NSCLC. ...

Movies are a source of entertainment and act as agents of recreation. Around the world, millions of people at one point in their lives will admit to having watched a movie. Whether it is at the big screens, rental DVD’s or streaming online. With a larger followership, movies are popular with both the young and old, the polarity of the film may be due to the theme expressed, or the role the main actor plays in the movie. Furthermore, the popularity of the movie may be because of affiliation with another big box office hit of the year ...

strains?” Researches on viruses have been carried out since time immemorial. Several vaccines, therapeutics, and targeted drug delivery systems have been developed only through extensive research on virulent strains. However, genetic engineering and molecular biology techniques have enabled scientists to manipulate, and develop new recombinant strains that may not occur in nature spontaneously. Proper containment of these engineered strains is essential as they might have properties that are entirely different from their parent strains. In September 2011 a researcher from Erasmus Medical Center, Rotterdam revealed how he had engineered avian influenza strain H5N1, and made it “more receptive to ...