Essays on Fibrin

Status of the document.

This document is a project proposal for the development of starch-based hemostatic products. Acknowledgement. Much thanks to the project supervisor who offered guidance in every step of the development of this proposal. Developing starch based hemostatic products Project summary. Purpose: This proposal is envisioned to develop a hemostatic agent from purified plant starch. In this case, the product of the reaction should be developed by the formation of microporous hemosphere particles after etherification, esterification and crosslinking of glucose molecules to form ethyl propanetriol (glycerol-ether links (1-3 deoxy propanol)). The second intention of this study is to investigate the properties ...

Introduction

It is critical to understand that mechanical interventions and thrombolytic therapy are the commonly used approaches to treat both venous and arterial thrombotic complications. However, this approaches offer several limitations that are hard to ignore. First and foremost, there is a possibility of excessive bleeding and damage to the walls of the blood vessel. Secondly, the approach may fail to reach reperfusion. Thus, the use and application of ultra-sound accelerated thrombosis offer an entire revolution in vascular medicine. Again, the technologyis meant to withstand the test of time. Cleary, the technology has reduced the body dosage that would be ...

Pathophysiology of Chronic venous insufficiency and Deep venous thrombosis

Chronic venous insufficiency is a condition that describes a dysfunction of the valves in the upper and lower extremities or the inability of the muscles in these regions to exert the required pressure that can force the flow of blood back into the heart. Essentially, the arteries are designed to supply oxygen-rich blood to all parts of the body while the veins are designed to transport the oxygen-deficient blood back into the heart (McPhee& Hammer, 2010). These processes are enhanced by the pressure exerted by the underlying muscles within the upper and lower extremities as well as the ability ...

A 36-year-old woman is married and has two adopted children. She is diagnosed with polycystic kidney disease (PKD), and she will soon have to go on dialysis or consent to a renal transplant. 1. What additional data should the nurse collect to help the patient make the best decision for herself? The nurse would need to collect previous health records of the patient. Gathering information on the cause of kidney failure and the medications used would help the nurse analyze the health issue in a precise manner. Gathering information on the patient’s psychological health and family would help ...

Introduction

Blood consists of erythrocytes and leucocytes suspended in it. Blood is pumped from the heart to the body through the arteries and it enters back in the heart through the veins. Blood without cells is known as plasma while serum is the straw colored liquid obtained after the removal of the clot. Plasma contains different proteins, nutrients and waste materials. There are different cases of blood disorders observed in humans.

Blood cells and platelets

The most abundant cells in the blood are the anucleate, biconcave erythrocytes. They contain a red pigment known as hemoglobin (Hb) that carries dioxygen (O2). Hb contains four subunits each ...

Introduction

According to Huether (2012), venous insufficiency is a medical condition characterized by the inability of the veins of the lower extremities to effectively push blood back to the inferior vena cava. The venous blood evades its normal antegrade flow path and refluxes down the veins in the lower segments resulting to lower limb venous congestion. Syndromes in this condition are mostly due to valvular incompetence common in the low pressure superficial venous system, although they may also be due to incompetence of the valves in the deep venous systems.

Pathophysiology of CVI

The failure of the valves of superficial veins is attributed to ...

Sepsis is a clinical condition that evokes an inflammatory response of the host immune system in response to clinically-suspected infections. It usually occurs in an individual with a weak immune system such as a post-surgery patient, organ transplant patient, cancer patients or an AIDS patient. It spreads throughout the body via the bloodstream. There are several degrees of sepsis such as severe sepsis, septic shock and refractory septic shock (Morrell, Micek & Kollef, 2009) that together make up the systemic inflammatory response syndrome (SIRS) (Mayr, Yende & Angus, 2014). Sepsis and septic shock are some of the leading causes of death in the world, ...

1.0 Introduction Hemophilia A (HA) is an inherited X-linked bleeding disorder that results from a wide range of mutations in the factor VIII (FVIII) gene which leads to the absence or quantitative and/or qualitative deficiency of the said blood clotting factor ( (Jacquemin, et al., 2000; Guillet, et al., 2006; Venceslá, et al., 2008). FVIII gene is one of the most extensively investigated of all human genes and these extensive studies have led to the identification of a wide range of different types of mutations responsible for HA. Some of the mutation types identified include point mutations (resulting in missense, nonsense ...

Part 1.

The pathophysiological template of an ischemic stroke involving the dominant left hemisphere of the brain is usually caused by the arterial occlusion resulting from a thrombus that embolized from a more proximal anatomical structure in the body that is closer to the brain, such as the heart and lungs and arterial plaques. The thrombus may cause a significant occlusion to the major intracranial arteries like the middle cerebral artery which carries the blood flow to the frontal, parietal and temporal lobes. A left middle cerebral artery stroke will manifest a right hemiplegia and hemiparesis with the upper extremities more significantly affected than the ...

Wound care, especially the management of chronic wounds is a costly affair. It is estimated that for every 1000 patients, 3.5 have a wound (Shepherd & Nixon, 2013). This implies that considerable resources are spent in the management of wounds. For instance, in the US, $2.8 billion is spent annually in the management of about 3-5 million chronic wounds. Chronic wounds negatively impact on the quality of life of affected patients since they affect their comfort, mobility, emotional well-being, life satisfaction, create caregiver burden, and time is spent seeking medical care (Buckley, Adelson, & Agazio, 2009). The implementation of prospective payment systems has ...