Apoptosis Research Papers Samples For Students

Immunogenic cell death: the role of SAGE

Immunogenic cell death: the role of SAGE

Introduction

Millions of cells are always being removed in the human body not only to regulate and coordinate the body’s biochemical pathways but also to keep the cells healthy. This particular systematic removal of cells occurs through a selective mechanism called cell death or apoptosis process. Apoptosis is not a new concept in the understanding of the biological workings of the body. This homeostatic death of body cells has been defined as a tolerogenic or a non-immunogenic event for many [1]. However, new discoveries have unearthed the existence of a different concept ...

Immunogenic Cell Death: The Role of RAGE

Introduction
Millions of cells are always being removed in the human bodyin order to regulate biological pathways and keep cells healthy through a particular mechanism called cell death or apoptosis. Through apoptosis, such homeostatic death of cells has been defined as a tolerogenic or a non-immunogenic event for many years [1]. However, during the past few years, scientists have discovered the occurrence of a different concept of cell death – immunogenic cell death (ICD), where the death of a cell stimulates a response from the immune system against antigens of a dead cell, and this mechanism of cell death may ...

In the heart, a large number of the vital pathway, which includes energy metabolism, stress response, and survival, apoptosis, oxygen sensing, and inflammation response are all regulated by reactive oxygen species (ROS) and a cellar redox state (Dickinson & Chang, 2011). Through upregulation of proapoptotic proteins and mitochondrial-dependent signaling pathways, ROS is part of a process of cardiac remodeling, cell death and hypertrophy (Dickinson & Chang, 2011). Molecular oxygen is a center for both formations of NO and regulation of ROS as significant energy metabolism by-products. Since the intermediates that are meant to be short-lived can either act as signaling molecules ...

Abstract

The research paper deals with the problem of whether or not cannabis and cancer are interrelated. There are arguments provided in favor of cannabis stimulating the growth and proliferation of cancer and counterarguments, claiming that not only has marijuana consumption no negative impact on human health, but it also has the potential of being used for medical purposes for treating brain, breast, lung, prostate, blood, oral, liver, and pancreatic cancer inasmuch as it serves as a natural inhibitor of tumor growth as well as providing apoptosis of malign cells. Cannabis treatment may also be used as a legitimate, harmless and far ...

Targeted therapies that include small molecule inhibitors and monoclonal antibodies have considerably altered the cancer treatment over the past several years. These drugs are currently a part of therapy for several widespread malignancies, including colorectal, breast, pancreatic, and lung cancers, as well as leukemia, multiple myeloma, and lymphoma. The action mechanisms, as well as toxicities of targeted therapies, are different from the action mechanisms of traditional cytotoxic chemotherapy. Targeted therapies are usually better endured than traditional chemotherapy, although they are linked to a number of unfavorable effects, like cardiac dysfunction, acneiform rash, proteinuria, thrombosis, and hypertension. Small molecule inhibitors are acted ...

1.0 Introduction
Down syndrome (DS) is a genetic condition caused by trisomy 21 (the presence of three copies of chromosome 21 rather than two). Although the actual cause of Down syndrome remains unknown, several risk factors increase the chances of a baby being born with the disorders. The primary risk factor, is the maternal, with about 80% of the cases of Down syndrome occurring in babies born by women above the age of 35. Other risk factors are genetic predisposition (indicated by siblings, another baby or parent with Down syndrome), immunologic problems, hormonal abnormalities, viral infection or x-rays. The risk ...

HeLa cell line is a human cancer cell line that does not undergo apoptosis or cell death, and can be continuously cultured indefinitely in-vitro (AccessScience Editors [ASE] 2014). In general, human somatic cell cultures cannot be maintained in laboratory conditions beyond certain no of generations. Hence, HeLa cells are very useful in medical research for studying cell behavior and cell death, in developing new cancer therapies and vaccines. Since their initial culturing, HeLa cells have been cloned several times, and distributed throughout the world for various research purposes. Though today several immortalized cell lines are available, HeLa still remains ...

Introduction

Most of the world’s chronic diseases are preventable by long term dietary behavior. Out of the ten major causes of deaths for Americans, diet is a contributing factor to at least five of them. These diseases are such as cardiovascular diseases, cancer and diabetes. A report by the Joint World Health Organization on diet made in 2003 revealed that, most of the world’s chronic diseases can be prevented by regular physical exercise and maintenance of a healthy weight. This finding is valid up to date. According to this report, a person’s genome determined their susceptibility to disease while external ...

Introduction

The human papillomavirus (HPV) is from the papillomavirus family which infects the cells in the skin or the mucous membrane. HPV is a non-enveloped double stranded virus which carries its genetic code from early (E1-E7) and late (L1-L2) proteins. The early proteins promote viral replication while late proteins are responsible for structural support or capsids of proteins. Two viral oncogenes together with the non-structural early proteins (E6-E7) were associated to the transformation of the tumor from benign to malignant stage. The aforementioned proteins influence carcinogenesis by promoting both the retinoblastoma (Rb) and p53 proteins. These proteins regulate cell growth and ...

Cancer is the abnormal proliferation and differentiation of cells in an abnormal tissue incongruent with the growth pattern of normal cells that persists even after the stimuli that evoked the change is withdrawn. The cell cycle check points at G1, G2 and at the end of metaphase that prevent transmission of genetically damaged DNA fail to occur. Transmission of faulty DNA results in either an abnormal rate of cell division and multiplication or abnormally constituted daughter cells.
The genes affected are the normal regulatory genes including growth promoting proto-oncogenes-normal genes that are prone to becoming cancerous on mutation ...

Abstract:

Strokes are a leading cause of morbidity and mortality in the developed world. Key to prevention and control of strokes is a thorough understanding of their etiology and the pathophysiologic processes that occur. A review of the literature regarding cerebrovascular disease was undertaken to more fully understand the changes that lead to strokes. The causes are manifold and there are many risk factors that may lead to pathology causing a stroke.
The third leading cause of death in the United States is stroke, it is also the cause of significant neurologic disorders and morbidity. A pathological process involving the blood vessels ...