Enzyme Case Studies Samples For Students

- Ingestion of fava beans increases the formation of free radicals in red blood cells which in turn causes disruption on the normal functioning or reduction of Glucose-6-Phosphate Dehydrogenase enzyme. Consequently, glucose-6-phosphate dehydrogenase reduces and therefore the red blood cells are incapable of defending themselves from the detrimental effects of reactive oxygen species. This makes the damaged cells to breakdown and rupture prematurely hence hemolysis.

Glucose-6-phosphate dehydrogenase pathway

The G6PD gene is located from base pair 153,759,605 to base pair 153,775,795 on the X chromosome.
- Fatty acid synthesis occurs in the cell cytoplasm. Fatty acid synthesis ...

Biology of Disease

Mode of action of;-
Dexamethasone
The Glucocorticoid receptors are discovered intracellularly in all tissues. They enter cells through inactive dispersion and structure a complex with a receptor protein (Rhodes & Hartnoll, 2002, P.10). This intricate then experiences an irreversible enactment and enters the cell core, where it ties to the DNA, hence prompting organic impacts instigated by these hormones, which include expanded hepatic gluconeogenesis, as well as expanded lipolysis (Ahmed, 2007, P.13).
Dexamethasone is utilized to treat numerous provocative and immune system conditions, for example, rheumatoid joint pain and bronchospasm. Idiopathic thrombocytopenic purpura, an abatement in quantities of ...

The doctor suspects mitochondrial disease which can occur at multiple levels in different mitochondrial processes. To help the doctor determine where the defect might have occurred:

1. Explain what would happen if the interconversions of the Cori cycle occurred and remained within a single cell.

The cori cycle refers to a pathway of carbohydrate metabolism which links the processes of anaerobic glycolysis (glucose breakdown) in skeletal muscle tissue and glucose synthesis that is gluconeogenesis in liver cells. Anaerobic glycolysis is the major source of energy in form of ATP for skeletal muscle cells when they are under intense activity; it generates ...

1.
The patient is diagnosed to have congestive heart failure. This is a heart disorder resulting to pulmonary vascular congestion with a reduced cardiac output. Among the diagnostic symptoms of the disorder include pulmonary complications, such as pulmonary edema, obstructive sleep apneas and pleaural effusions (Figueroa and Peters 2006). It is also characterized by the main symptoms of orthopnea, fatigue, dyspnea, paroxysmal nocturnal dyspnea and peripheral edema (Grimshaw, Khunti and Baker, 2001), which are all present in the clinical symptoms presented by the patient Mabel. During the exacerbation of the congestive heart failure, the patient will benefit from continuous ...

PHYSICAL EXAM:

You will be expected to write up your response as follows:
List of Differential Diagnoses [rank ordered]
A. Congestive Heart Failure
B. Angina
C. Hypercholesterolemia
D. Myocardial Infarction

E. Diabetes Mellitus

F. with Grade II diastolic heart failure.

G. Hypertriglyceridemia

H. GERD
I.

J. Hypertension

Leading hypothesis : Congestive Heart Failure
Active Alternative hypotheses
Must not miss diagnoses [critical rule outs]
Congestive Heart Failure
Angina
Hypertriglyceridemia
Hypercholesterolemia
Most common diagnoses [reasonable alternatives]
GERD
Hypertension
Diabetes Mellitus
Presumptive Diagnosis [assumption]
Congestive Heart Failure

Treatment Plan

Non-pharmacologic / lifestyle interventions (provide rationale)
• Modify Diet.
- Advance to a low-sodium, low-cholesterol, low-fat, solid diet as tolerated R: to minimize metabolic demands ...

INTRODUCTION

The 6-month infant presents to the clinic with splenomegaly and lipemic samples at birth . Screening of complete blood count at birth was ordered, but could not be conducted, owing to the lipemic nature of samples. Subsequently, the patient was referred to a pediatric gastroenterologist, who examined the baby to be oversized with weight in 99th percentile, 81st percentile for height and 70th percentile for head circumference, and body mass index (BMI) in the 99th percentile. He exhibited multiple lipomas on one ear lobe, in the right eye, neck and abdomen. Abdominal examination presented a soft, nontender abdomen with splenomegaly ...

I. UNDERSTANDING THE DISEASE AND PATHOPHYSIOLOGY
1. How is acid produced and controlled within the gastrointestinal tract?
The production of acid occurs in the stomach by cells that are therein. The cells found in the stomach produce intrinsic factors and hydrochloric acid. There are chemical messengers that help during the activity. They are histamine, gastrin and acetylcholine. Gastrin helps in stimulating the cells to produce secretions when food enters the stomach. An enzyme somatostatin inhibits the secretions when needed. The digestion takes place in three phases; the cephalic phase, gastric phase and the intestinal phase. It is in the ...

Helicobacter pylori, which was formerly known as Campylobacter pyloridis, is a microaerophilic, Gram-negative bacterium present in the stomach. In 1982, Robin Warren and Barry Marshall discovered that it was found in persons who were suffering from chronic gastric ulcers and gastritis, diseases that were not formerly thought to have been caused by microbes. It is also associated with the development of duodenal ulcers and stomach cancer. Nevertheless, more than 80 percent of persons infected with the bacterium show no symptoms, and it has been contended that it may have a crucial role in the natural ecology of the stomach (Blaser, 2006).
...