Essays on DNA Replication

1. Explain in general terms the process of DNA replication. DNA replication refers to the process whereby DNA makes its own copy during the process of cell division. During this process, the DNA strands unzip themselves since helicase enzyme breaks the hydrogen bonds between the complementary strands. As this occurs, a replication fork is created. Each individual strand (leading and lagging) will be used as templates. A primer attaches itself to the leading strand and the synthesis of DNA begins, whereby DNA polymerase adds nucleotides to the synthesized strand. This is a continuous process and occurs in 5’ to ...

Biology

(Department)

DNA and its importance in our lives

Introduction Deoxyribonucleic acid (DNA) is a long linear polymer located in the nucleus of a cell. It is developed from nucleotides and shaped like a double helix. It is related to the transmission of hereditary information from one generation to the second generation. DNA contains the information for the development as well as reproduction of an organism, thereby leading to a normal life. In the year 1953, James Watson, a biologist, and Francis Crick, a physicist, discovered the structure of DNA in a laboratory in England (LEROY, 2003). The structure of DNA helped scientists to know the process ...

DNA (Deoxyribonucleic Acid)

Deoxyribonucleic acid, DNA, is the primary structure that carries the genetic material in cells of living organisms and some viruses. The DNA is made up of strands of nucleotides that are made up of nitrogenous bases, a phosphate compound and, a ribose sugar. The nucleotides form a ring or ladder that over lapses to form double helix strands of polynucleotides. DNA aggregates to form the chromosomes that are strictly found within the nucleus of the cell. Some DNA are found in the ribosomes outside the nucleus. In the DNA structure, the series of the bases is arranged, and the sequence in one ...

Introduction: Genetic mutations are associated with changes in the genomic sequence that are the main cause of diversity among organisms. The changes in genetic sequence can occur at any instance and are known to have different consequences. Mutations are often associated with a change that affects the nucleic acids in most organisms. Nucleic acids are considered as the building blocks of DNA. On the other hand, DNA are associated with the storage of information that is transferred to the offspring during reproduction. Mutations are associated with diversity and considered as an essential part in evolution. Genetic mutation is considered to ...

Introduction/background

Saccharomyces cerevisiae is an organism that can exist either as a singled-cell organism or as pseudomycelia. It is used in many scientific studies. It is commonly known as baker’s yeast. Saccharomyces cerevisiae is widely employed in scientific studies mainly due to the following reasons: it has a sequenced genome, it is easy to maintain in the lab, researchers can easily manipulate its genetics, and it grows rapidly. Saccharomyces cerevisiae can live with two genomes (diploid, n=32) or one genome (haploid, n=16). Consequently, the organism can undergo meiotic differentiation. In diploid phase, cells of the saccharomyces cerevisiae are more resistant to ...

Most chemotherapy drugs are designed to block DNA replication; majority of the generally and successfully drugs are DNA-damaging agents. The DNA targeting has proven to result in comparatively potent and discerning distribution of cancerous cells. Compounds which are empirically identified with anticancer activity have been indicated to target DNA as the crow flies or through enzyme inhibition which controls the integrity of the DNA of offers the DNA building blocks. With the revelation of the DNA structure various therapeutic modlaities have been established namely; the antimetabolites which, depletes the nucleotides comprising folic acid, an example being methotrexate. Alkylation agents ...

Question 2

Non covalent bonds attach the paired bases that compliment each other. The bond serves a strengthening feature in attaching the complimentary pairs. The bases that are complimentary in the bases of a DNA are G= guanines, A= adenines, C= cytonines and T= thymines. The bonding process of bases is done when G bonds with C, T bonds with A. This is the rule for bonding of the DNA bases. These are strongly found between the base and nucleotides that are completed when the four bases interact to make a adenosine monophosphate (Audesirk, et al., 2011).

Structure of the DNA 3

The polymer of the DNA is referred ...

Biology

1. There are certain situations where we practice selective behavior that favors certain traits. A lot of times when individuals are acting as a member of certain groups, their actions are usually tailored towards being in conformity with those of other members of the same group. For instance a prominent member of a certain professional organization may decide to listen to a particular brand of music and because other members of the group interact with the individual and look forward to them as an important personality, others might also want to listen to the same brand of music. Also, if members of the ...

Microevolution refers to the change that occurs in allele frequencies as a result of natural selection, gene flow, genetic drift and mutation. Macroevolution on the other hand refers to trends, big-scale patterns and change rates in families and other more overall species’ groups. A species refers to a group of organisms that are able to interbreed giving rise to viable offspring. A population refers to organisms of the same species that have interbred and live at the same geographical location at the same time. There are four forces that influence micro to macro evolution. These include; mutation, selection, genetic drift ...

Chemistry

Trizivir: Ingredients: 3 synthetic nucleoside analogues with inhibitory activity against HIV-1. “A recently approved antiretroviral looks like a nucleoside reverse transcriptase inhibitor (NRTI), but it acts like a protease inhibitor” (Portyansky 1999).

Active Ingredients:

1. abacavir sulfate, 300 mg (aka Ziagen™) 2. lamivudine, 150 mg (aka EIVIR™ or 3TC™) 3. zidovudine, 300 mg (aka RETROVIR™ or azidothymidine, ZDV or AZT because of Azide functional group).

Additives:

1. titanium dioxide 2. hypromellose 3. yellow iron oxide

Coating on Tablets

Is FD&C Blue No. 2, hypromellose, polyethylene glycol, titanium dioxide and yellow iron oxide

Inactive Ingredients: 1. sodium starch glycolate ...