Essays on Transcriptase

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Description of HIV

Human Immunodeficiency Virus (HIV) is a virus that weakens and destroys the immune system of the body so that the body cannot defend the infection. HIV positive person also possesses AIDS (Acquired Immunodeficiency Syndrome), and if HIV is treated at its early stage, the risk of AIDS can be averted. If an HIV-positive person is diagnosed with AIDS, it means that the complete destruction of the immune system has been accomplished by the HIV and that increase the vulnerability of the patient towards various opportunistic infections. The ...

Abstract

Over thirty years after its identification, HIV and AIDS remains a somewhat elusive virus, particularly when it comes to its history as a human infectious agent, and resourcing a complete epidemiology of the disease. Part of the problem is that so many antiretroviral drugs have come out and have either been used or prescribed incorrectly. In addition, the virus, like many other reverse RNA transcriptase viruses, has a very high aptitude in terms of developing resistance to drugs at a very rapid rate. What further complicates matters is how quickly it has spread. It will probably never truly be ...

INTRODUCTION

In the 1980s a new disease was spreading. It was previously unknown, but seemed quite contagious and quite virulent. HIV, the Human Immunodeficiency Virus, is defined exactly as it sounds. It is a virus that causes an infection that negatively affects the immune system. That infection attacks and weakens the immune system, making an individual at greater risk for contracting other opportunistic diseases. When the immune system becomes too damaged it leaves the patient open to contracting AIDS, the Acquired Immunodeficiency Syndrome, which essentially disables the immune system, which leaves sufferers to deal with many of unpleasant symptoms associated ...

Introduction

Tooth development involves a complex process whereby teeth are formed from embryonic cells, and then eventually mature after erupting as evident in the mouth (Eckhardt, Jágr, Pataridis, & Mikšík, 2014). The development usually originates from mesoderm and ectoderm. At the ectoderm found in the oral cavity, there is the development of enamel and other tissues also come from associated mesenchyme. All teeth don’t develop at the same time, but rather in stages (Eckhardt, Jágr, Pataridis, & Mikšík, 2014). First buds are always observed in the region of anterior mandible, followed by anterior maxillary area then finally ...

HIV/AIDS

December 1, is World’s AIDS Day. At the initiative of the World Health Organization, for the first time, this date was marked as World AIDS Day on December 1, 1988. At that time, around 7 million people were infected with HIV. In 5 years there were already 14 million, today more than 36.9 million people in the world are living with HIV (“Global Statistics”). The first notice of new disease was placed in 1981 in the American weekly newspaper “Morbidity and Mortality Weekly Report”. According to some scientists the human immunodeficiency virus derived from green monkeys immunodeficiency virus. ...

Human Immunodeficiency Virus, a main cause of worldwide AIDs, belongs to the Lentivirus genus of Retroviridae family. Pathogen causes chronic type of symptoms, taking a long time of latency it constantly keeps replicating inside human body. HIV is categorised into two types, HIV-1 and HIV-2. The genome of this retrovirus consists of two single-stranded RNA molecules. Though, both are involved in AIDS, HIV-2 seemed less virulent and demonstrated more frequent connections with the disease of central nervous system (Fanales-Belasio et al. 5). Like other retroviruses, the genes located on HIV chromosome are gag, pol, env. The functions of gag, pol ...

1. In your own words explain why this paper is important or significant The article is very informative and significant since it introduces another breakthrough in DNA sequencing and analysis. It highlights the polymerase chain reaction which is the new way of identifying mutant genes in both homozygous and heterozygous organisms. The technique uses primers to amplify segments of the DNA by many folds such that it clearly identifies the mutant genes faster than all the other methods. The paper points out important milestones that genomics and gene sequencing has undergone over the years. Geneticists usually use the ...

- The answer to this question depends on the definition of an STD. For instance, Shigella was once though to be a Gastrointestinal disease, but with modern sexual practices and the increase of oral to anal intercourse it is now becoming an STD as well. Therefore, no precise number of STDs can be stated but there are now >30 infections classified as predominantly sexually transmitted (Harrisons, 2008, p. 822) - The most common viral STD is HPV. It is said that nearly ½ of the population is infected with the virus at any given time. Both males and females can ...

Human Immunodeficiency Virus, HIV is a retrovirus, which is a unique virus family consisting of RNA as the genetic material instead of DNA. This genetic material is surrounded by an envelope of lipoprotein. HIV differs structurally from other members of the family retrovirus. It is roughly spherical and has a diameter of around 120 nm. Human Immunodeficiency Virus comprises of two copies of non-covalently joined positive single-stranded RNA enveloped by a conical capsid that consist of the p24 viral protein, which is typical of lentiviruses. Lysine tRNA is reverse transcriptase that is magnesium dependent and is involved in the packaging of both ...

Introduction

Gene expression is the process through which the information that has been encorded in the gene is firstly converted into messenger RNA and then finally to a protein. The study of gene expression is critical especially to the biological student and more so to one who would like to study biology related course like microbiology in future. Therefore, it is important to note that we study gene expression in order to determine how the genes and the proteins which they encode functions in the intact organism. Zhang (2006), Another reason why we study gene expression is in order to ...

Chemistry

Trizivir: Ingredients: 3 synthetic nucleoside analogues with inhibitory activity against HIV-1. “A recently approved antiretroviral looks like a nucleoside reverse transcriptase inhibitor (NRTI), but it acts like a protease inhibitor” (Portyansky 1999).

Active Ingredients:

1. abacavir sulfate, 300 mg (aka Ziagen™) 2. lamivudine, 150 mg (aka EIVIR™ or 3TC™) 3. zidovudine, 300 mg (aka RETROVIR™ or azidothymidine, ZDV or AZT because of Azide functional group).

Additives:

1. titanium dioxide 2. hypromellose 3. yellow iron oxide

Coating on Tablets

Is FD&C Blue No. 2, hypromellose, polyethylene glycol, titanium dioxide and yellow iron oxide

Inactive Ingredients: 1. sodium starch glycolate ...

Telomerase also known as telomere terminal transferase is a type enzyme in all vertebrates that extends Die ribonucleic acid sequence by repeating TTAGGG to the Die ribonucleic acid terminal strands in the region known as the telomere. It is found in adult germ cells, fetal tissues, and tumor cells. Telomere is the region of repeated nucleotide, which is made up of non-coding Die ribonucleic acid material. The region prevents loss of vital Die ribonucleic acid from chromosome terminals. This results to only a hundred to two hundred nucleotides being lost each interval the chromosome is duplicates, thus no damage is caused ...

HIV VIRUS

The HIV virus is the causative agent of Human Immunodeficiency Virus (HIV). It usually infects the CD4 + T Helper cell by binding to the cell membrane, this is then followed by membrane fusion; a process that allows the virus to release viral particles into the host cell. Once infected, the T-Helper cell turns into a HIV replicating cell since the viral RNA is converted into DNA by reverse transcriptase a process facilitated by the viral proteins [ CITATION bio \l 1033 ]. The double stranded viral DNA is then transported to the nucleus where it is fused with the normal host DNA by ...