Fibrosis Research Papers Samples For Students

The purpose of this paper is to review the etiology, pathophysiology, clinical manifestations, inheritance patterns, and recent advances in disease management of cystic fibrosis. Cystic fibrosis is a progressive and lethal disease resulting from an autosomal recessive gene (Singh, Rebordosa, Bernholz, & Sharma, 2015). The major problem associated with cystic fibrosis is the repeated lung infections that over time severely damage the lungs, scar and widen the passageways and limit the ability to breathe (Cystic Fibrosis Foundation, n.d.). As of 2013, there are an estimated 70,000 cystic fibrosis patients globally with 33,000 of them in the United States ( ...

Introduction

Cystic fibrosis is an autosomal recessive condition that is caused by the mutation of the cystic fibrosis trans-membrane conductance regulator. The mutation affects the absorption of chloride ions which impairs the movement of sodium and water at the cellular level. This results in production of abnormally thick secretions that cause inflammation and damage to the cell. This affects the functioning of the organs. It is one of the most common genetic disorders that affects Europeans. Statistics indicating that one out of 2381 people in the United Kingdom suffer from the condition.
The complexity of the disease calls for a ...

Abstract

Cystic fibrosis is an autosomal recessive genetic problem with major infections to lungs, pancres, intestine and liver. The main characteristic of the disease is abnormal transport of chloride, and sodium in the epithelium leading to thick secretions.
It usually results from mutation in the gene for a protein known as cystic fibrosis trans-membrane conductance regulator (CFTR). This is a hormone which is usually involved in various body excretion processes. The main method of transmission of the disease is through genes. However, research has proved that it can be still transferred among people with no DNA connection
The disease is ...

Cystic fibrosis

Cystic fibrosis is a disease relating to the exocrine gland function. It involves multiple organ system as a whole, but there are some specific organ dysfunctions caused by this condition. These are the chronic respiratory infections, and pancreatic enzyme insufficiency. There are also some forms of complications that are usually associated with the untreated patients. Pulmonary issues or involvement is found in 90 percent of patients surviving the neonatal period. It has been noted in recent times that the major cause of death relating to the cystic fibrosis is the end-stage lung disease associated with it.
In the affected individuals, ...

Nurse Responsibilities

A nurse is a medical professional who focuses on taking care of sick individuals so that they can return to or improve their optimal health status (Philip, 2003). Unlike other medical professionals, a nurse has a lot of responsibilities. Some of a nurse’s main responsibilities include promotion of health, reducing the risks of a disease or treatment, and control of the spread of a disease. Sure there are a lot more responsibilities that a nurse has to fulfill (it may even vary from country to country) but this paper will only focus on these three.

Health Promotion

Nurses are considered members of the primary healthcare team. Primary healthcare ...

Introduction

Cystic Fibrosis (CF) is the most prevalent genetic disorder in the Caucasian population, with an incidence of 1 in 2500 births. CF is a disease that affects many organs including the upper and lower respiratory tracts, pancreas, intestines and reproductive system. Over the past 20 years, our understanding of the manifestation and management of the disease has progressed dramatically. CF was once considered a condition of childhood and there was very little expectation that children would enter adult life. However, CF has become a multisystem adult disease with the increased survival attributable to advancements in standardized treatment, introduction of ...

Research shows that around 30, 000 Americans have Cystic Fibrosis with over 1000 new cases diagnosed every year. Analysts suggest that it occurs evenly to both the females and males and affects generally every race. This condition is more common among the white babies. One in every 3,200 live white births in comparison to one in every 3,900 live births amongst all Americans appear to be suffering from the condition. At the age of three, most patients are diagnosed and only ten percent of the most recent cases are usually by age eighteen and above (Children’s ...

Cystic fibrosis is a chronic, progressive and often deadly genetic disease that affects the body’s mucous glands. It follows that cystic fibrosis (CF) is evident in the body’s digestive and respiratory systems, particularly in children and young adults (Flume et al., 2007). In some cases, it affects the reproductive system and the sweat glands. A CF-like disease has been known over the past two centuries, but it was in 1938 that the term cystic fibrosis was first used.
CF may also be considered to be an autosomal-recessive disease. Its estimated heterozygote occurrence is one for every twenty ...

Part 1

Cystic fibrosis is a disorder that has been proven to have profound effects on the genetic makeup of an individual. This condition mainly affects the lungs and the alimentary canal. The other body organs likely to get affected by the disease include the kidneys, pancreas, intestines and the liver. It has been established that the condition compromises the functioning of the body cells responsible for the production of digestive, mucus and sweat juices (Mayo Clinic., 2016). Under normal circumstances, these cells are usually thin and slippery but if they become affected, the secretions they produce turn sticky and thick. ...

Cystic Fibrosis is a genetic disease characterized by the buildup of sticky and thick mucus inside the body that can potentially damage the organs (US NLM, 2012). The two most common signs of Cystic Fibrosis are damaged respiratory system and chronic digestive problems. The severity varies among the affected individuals. The disease is most common among Caucasian people (1 in every 2,500 newborns) and most rare among the Asians (1 in every 31,000 newborns) (US NLM, 2012).
Cystic Fibrosis produces thick mucus that can block the airways in the lungs, leading to bacterial infection and severe breathing ...

Qualitative research is relatively new to nursing research. Despite its being usually underused and undervalued, qualitative research is increasingly contributing to nursing knowledge (Hall, 2006). The purpose of this paper is to compare qualitative and quantitative research in order to examine their differences. The comparison will be done by examining an article using the qualitative method and two articles using the quantitative method. All articles are on the same topic, cystic fibrosis. All articles were published in well-known and reputable journals. The qualitative article is by Carpenter and Narsavage (2004) and the quantitative ones are by De Bias, et ...

Research Paper

Research paper

The article “One breath at a time: living with cystic fibrosis” presents a qualitative investigation to describe the living experiences of families caring for a patient of cystic fibrosis (CF). Several quantitative, ethnographic and grounded theory studies have been done involving the patients of CF and their families. These studies aimed at research on stressors and interventions for CF and are valuable in understanding coping in families lived with (or living with) CF for extended periods of time. However, these studies do not explain the experience of living with a family member with CF.
The objective of this research was ...

My thesis statement is that medical charities are utmost important for the nation as well as humanity in general as they help to cope with medical emergencies and necessities thus saving several precious lives and providing much needed medical help on time. This is the reason I have chosen medical charities from among the other charities to donate the sum of $10,000 at my disposal. For efficiently gauging which are the best medical charities, I have done some preliminary research by poring through their websites in detail supported by secondary research of going through their performance parameters and ...

Abstract

Cirrhosis is 12th on the list of leading causes of death in the US. Cirrhosis is characterized by scarring of the liver tissue due to inflammation that could lead to liver failure and death. Some patients develop cancer in due course of the illness. The scarring, which is usually permanent, covers the outer layer with collagen, makes the liver very rigid and limits the exchange of blood between the portal vein and the liver, thereby creating excess pressure in the hepatic portal vein. The scarring renders the removal of toxin such as alcohol difficult due to depletion of hepatocytes. ...

HCV or Hepatitis C virus infection has over 5 million people affected in US (Chak, et al., 2011) and over 120 million people worldwide hence a global health problem. This virus belongs to Hepacivirus genus and Flaviviridae family (Lindenbach, et al., 2007) with six genotypes and with more than seventy subtypes. In approximately 85% infected individuals it may be unresolved, hence representing a significant hepatocellular carcinoma and liver cirrhosis cause. It is viewed as commonest cirrhosis cause and chronic liver disease in the world. It also represents the main liver transplantation cause in USA, Europe, and Australia (Thimme, et ...

LIVER DISEASE

Pathophysiology of the Disease
Liver disease is a major concern all over the world. The initial stages are referred to as hepatic fibrosis. In case of severe and critical advancement, the stage is called cirrhosis. In this stage the disease is not reversible; the fibrous is scarred and the hepatic structure is characterized with interconnecting bands (Regenstein & Dickerson, 2006). Normal working of the liver is hindered by the resulting insufficient blood flow and continuous destruction of hepatocytes (Sorrell, Maddrey & Schiff, 2011).
The etiological factors which lead to cirrhosis include Hepatitis B, Hepatitis C and abuse of ...

(6 points) Compare and contrast mitosis and meiosis (include at least 3 comparisons and 3 differences).

Both mitosis and meiosis are usually associated the cytokinesis
In both processes, end result is usually production of daughter cells from the parent cell
The fundamentals in both processes are the same in that there is breakdown of nuclear membrane, genetic material separation into two groups, cell division and eventually the nuclear membrane in the cells reform

Differences

In meiosis, there are two rounds involved in genetic separation while in mitosis there is only one round.
In meiosis, there is separation of homologous chromosomes ...

Description and challenges

Hepatitis C is a type of infection that is caused by a virus that attacks the human liver resulting in inflammation. The virus is called Hepatitis C virus (HCV). The infected people show less or no symptoms during its early stages of infection (Michael, 2014, p 1178). Hepatitis C virus is considered the most dangerous of the Hepatitis infections. The virus is transmitted through the contact with contaminated blood, mostly through needles that are shared through the use of illegal drugs.
One challenge with Hepatitis is that, during its early stages, one cannot know if he is infected or not. This ...

Introduction

Human Engineering is an applied science that coordinates the design of systems, devices and the working conditions with the requirements and capacities of workers. It can also mean the alteration of human body cells in order to fight genetic and chronic diseases or to improve human intelligence, appearance, memory or some other desirable traits (Baylis & Jason, 24). In this context, human engineering is viewed from the context of genetic modifications of human cells. Genetists who conduct scientific research into human engineering and sports owners advocate for it while purists who advocate for the maintenance of the human species from ...

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Introduction
Cirrhosis is caused by liver injury that results in fibrogenesis and inflammation. These problems result in collapse of liver structures and significant distortion of hepatic vascular structure. This distortion leads to elevated resistance to portal blood flow as well as portal hypertension. Moreover, hepatic synthetic dysfunction is also caused as a result of these problems. Clinically, liver cirrhosis is considered as an end-stage disease that could result in death until liver transplantation is performed (Tsochatzis, Bosch, & Burroughs, 2014).
Liver cirrhosis is an important cause of morbidity and mortality in most of the developed countries. In ...

COPD is a medical condition that is characterized by alteration in lung parenchyma, bronchitis, emphysema and narrowing of the respiratory passages. It occurs as a consequence to chronic inflammation reaction involving the respiratory tract. The mucous secretion and fibrosis associated with chronic inflammation, can cause blockage and narrowing of the airway. Bronchitis refers to inflammation of the inner lining of the lung, while, emphysema is a clinical condition that occurs following the long term destruction of lung parenchyma. Bronchitis and emphysema are both characteristic features of COPD. Destruction of lung parenchyma causes loss of alveolar attachment and decreases the ...

Introduction:

Occupational exposure to silica crystals has long been identified and recognized in most of the industries. There are various industries that involved the silica dusts, where some are highly exposed beyond the threshold limits for the substances. The problem with the occupational exposure of workers to silica crystals are often not taken seriously be employer and employee alike. Exposure to silica in the occupational environment results to health effects such as silicosis and other related diseases. People who are working with these crystals are prone to respiratory effects as well. There is a problem in the safety and health ...

Description of Disease

Chronic obstructive pulmonary disease or COPD is a progressive illness due to which the sufferer is not able to breathe easily. In this connection, progressive means that this disease worsens with the passage of time. In COPD, the patient’s coughing produces mucus in large amounts, puffiness, breath shortness, tightness of chest, and similar other symptoms (Currie, 2011).
There are two major conditions in COPD i.e. chronic bronchitis and emphysema. Emphysema refers to the condition whereby damage of the walls between several air sacs occurs. Consequently, the air sacs become flaccid due to the shape loss. Such damage also ...

Abstract

The acute respiratory distress syndrome is a form of injury to the lungs that impedes the supply and uptake of oxygen from the alveoli resulting in a state of severe hypoxemia, dyspnea, anxiety, and tachypnea. This review has established that genetics may be playing a role in increasing one’s susceptibility to acute respiratory distress syndrome (ARDS. Moreover, biomarkers would also play a significant role in the diagnosis and treatment of the disease. However, it still remains unclear on the type of genes and biomarkers that play a role in causing ARDS. It has also been established that young children (less than 2 years ...

Pancreatic cancer (PC) is a malignant cancer that originates from cancerous cells in the pancreas. It has been estimated that 90-95% of pancreatic cancers are adenocarcinomas that originate from the exocrine part of the pancreatic tissue. Adenocarcinomas (ductal pancreatic cancer) are tumors that exhibit glandular architecture when observed under a light microscope. Pancreatic carcinoma accounts for fourth highest occurrence of cancer related deaths in the United States. The prognosis for the various stages of pancreatic cancer is poor with an estimated 25% survival rate for a person diagnosed with stage 1, while only 5-6% survival rate estimated for a stage 5 diagnosis according ...

A condition affecting the system of veins in legs with venous hypertension resulting in different pathologies that involve swelling, ulcerations, pain, skin changes, and edema is called chronic venous insufficiency (Eberhardt and Raffetto, 2005).
It is necessary to understand normal venous function and anatomy to analyze the venous insufficiencies pathology. The peripheral venous system serves as a conduit returns blood into the heart and as a reservoir where blood is stored. Appropriate operation of the peripheral venous system is dependent on a series of muscle pumps and valves (Eberhardt and Raffetto, 2005). Blood entering the venous system of lower extremities has ...

Genetic testing also known as DNA based test, involves direct examination of DNA molecules to test for genetic disorders and diseases (Gene testing, 2010). According to the Human Genome Project Information (2010), Genetic testing can be used for various reasons to include:
- Identifying people who carry one copy of genes causing diseases such as Huntington’s disease.
- Pre-symptomatic testing of adult onset diseases/disorders such as Huntington’s disease
- Forensic testing and determining paternity.
- Newborn screening and pre- natal testing.
DNA stands for Deoxyribonucleic acid, and these are chemical Data bases ...

Dear Grandma,

Our body has tissues and organs that are made up of different types of cells. Each cell contains the deoxyribonucleic acid also known as DNA. This double-stranded DNA is made up of 4 chemical molecules also known as bases: adenine (A), guanine (G), cytosine (C) and thymine (T). In the DNA, A always pairs with T; C always pairs with G. These strands are nothing but sequences of these bases that run really long. So typically a short sequence of DNA if written down in English will read:

AGTCCCGGTTC

TCAGGCCAAG
The DNA sequences are 99% alike in all humans, but ...