Essays on Phosphatase

Diseases and disorders occur due to many reasons such as bacterial or viral infections, can genetically be inherited or they can be linked to nutritional deficiencies. One such disease linked with nutritional deprivation is termed as Rickets or Osteomalacia. It is an illness which has been around for many centuries and mainly affects children. However, the prevention of rickets has been made possible with research and discovering the factors which can help improve bodily health. Yet, the disease is a commonly recurring one in developing countries where infants and young children are exposed to a nutritional deficiency of Vitamin ...

Introduction

Cancer is a disease that is associated with high morbidity and mortality rates. The Prognosis of the diseases in many of the patients is also poor (Adorno & Brownell, 2014). The Economic cost involved in treating the conditions and other factors serve as an incentive for studies into approaches for the identification of high risk people. The development of brain metastases in patients diagnosed with lung cancer further amplifies the disease burden (Adorno & Brownell, 2014). This paper summarizes two articles in which the authors present content on the use markers in the identification of high risk populations.

Summary of Articles

The article by ...

Introduction

Cancer is a disease that is associated with high morbidity and mortality rates. The prognosis of the diseases in many of the patients is also poor (Adorno & Brownell, 2014). The economic cost involved in treating the conditions and other factors serve as an incentive for studies into approaches for the identification of high risk people. The development of brain metastases in patients diagnosed with lung cancer further amplifies the disease burden (Adorno & Brownell, 2014). This paper summarizes two articles in which the authors present content on the use markers in the identification of high risk populations.

Summary of Articles

The article by ...

Vid30 complex participation in the degradation of CDC25 in yeast and their role in Ras/ cAMP/ PKA pathway

Background: Unicellular organisms such as Saccharomyces cerevisiae in its total life cycle is exposed to diverse and changing nutrient conditions. Thus, in order to survive and achieve a competitive advantage, it has adapted itself such that it not only uses the wide range of available nutrient sources but also the sources that are nutrient rich. It mainly uses fructose and glucose by rapidly fermenting to alcohol. In response to these nutrient conditions, the intracellular trafficking transcription and turnover of protein from nutrient transporters (e.g. Hxts) get regulated. Therefore, when the availability of the glucose increases, the expression of low- ...

Immunogenic cell death: the role of SAGE

Immunogenic cell death: the role of SAGE

Introduction

Millions of cells are always being removed in the human body not only to regulate and coordinate the body’s biochemical pathways but also to keep the cells healthy. This particular systematic removal of cells occurs through a selective mechanism called cell death or apoptosis process. Apoptosis is not a new concept in the understanding of the biological workings of the body. This homeostatic death of body cells has been defined as a tolerogenic or a non-immunogenic event for many [1]. However, new discoveries have unearthed the existence of a different concept ...

Immunogenic Cell Death: The Role of RAGE

Introduction Millions of cells are always being removed in the human bodyin order to regulate biological pathways and keep cells healthy through a particular mechanism called cell death or apoptosis. Through apoptosis, such homeostatic death of cells has been defined as a tolerogenic or a non-immunogenic event for many years [1]. However, during the past few years, scientists have discovered the occurrence of a different concept of cell death – immunogenic cell death (ICD), where the death of a cell stimulates a response from the immune system against antigens of a dead cell, and this mechanism of cell death may ...

Introduction

Millions of cells are always being removed in the human body in order to regulate biological pathways and keep cells healthy through a particular mechanism called cell death or apoptosis. Through apoptosis, such homeostatic death of cells has been defined as a tolerogenic or a non-immunogenic event for many years [1]. However, during the past few years, scientists have discovered the occurrence of a different concept of cell death – immunogenic cell death (ICD), where the death of a cell stimulates a response from the immune system against antigens of a dead cell, and this mechanism of cell death may ...

Introduction

Capsular polysaccharides are of high molecular mass and low molecular weight cell-surface polysaccharides of Gram-positive and Gram-negative bacteria (Wang et al. 2000). They facilitate evading the immune system; therefore, the production and extraction of this layer is a prospective therapeutic target (rcsb.org). In the Gram-positive bacterium Streptococcus pneumoniae, strain TIGR4 the Cps4B is tyrosine protein phosphatase CpsB. The phosphatases have capability to dephosphorylate their analogous autokinases, instead of their similar functionality equivalence; they don’t demonstrate sequence homology. This capsule or CPS act as an interface border between a microbe and its environment that presents an expansive biological and clinical significance. ...

Von Gierke Disease

Introduction Von Gierke disease or Glycogen Storage Disease Type 1 (GSD-1) belongs to a group of rare metabolic disorders with a reported incidence of 1 case per 100,000 births per year. The clinical condition results from deficiency of key enzymes in the glycolytic pathway resulting in an increase in intermediate metabolites and accumulation of glycogen in the affected tissues. It is a genetic disorder with a natural history of severe developmental abnormalities and long term complications. This paper provides an overview of GSD-1 based on studies published in peer reviewed journals with a focus on its genetic determinants, clinical picture, available therapeutic ...

(Author)

Regulation of Xiap Protein in Breast Cancer Breast Cancer Breast cancer is the type of cancer that develops in the tissues of the breast. Two most commonly reported types of breast cancer are “ductal carcinoma” and “lobular carcinoma”. Ductal carcinoma is initiated in the lining of the milk ducts, which are thin tubes involved in carrying of milk from lobules of the breast to the nipple. Ductal carcinoma can be in the form of Invasive ductal carcinoma (IDC) as well as Ductal carcinoma in situ (DCIS). IDC is the most commonly found type of breast cancer ...

Introduction

Components that enhance the rate at which chemical reactions that place are referred to as enzyme (Lehninger, Nelson, & Cox, 2008). Through the reduction of the amount of activation energy that is necessary for a successful completion of a reaction, enzymes manage to reduce the time and resources needed to complete the reaction (Cooper, 2000). The activity of a given enzyme is, usually, affected by the level of different parameters such as temperature, pH levels, concentration of the enzyme and substrate concentration (Eed, 2012). Enzymes work best within a given range of values for each of these factors and deviation from these values ...

Sorting of the Receptor

Response to questions Q. A Describe the main pathway turned ‘on’ by the EGFR to regulate cell growth MAPK/ERK pathway is the main pathway, which is turned on by EGFR in order to regulate cell growth. This path comprises of a chain of proteins within the cell, which communicates a signal from the cell receptor surface to the DNA within the cell nucleus. When a molecule binds to the receptor at the cell surface, a signal is induced and ends when the DNA expresses a protein, which in turn produces some changes within the cell. One of the common changes are cell ...

Article Review

Article Review: The Surprising Role of Amyloid Fibrils in HIV Infection Summary Human Immunodeficiency virus which causes Acquired Immune Deficiency Syndrome has been around for some time. The initial identification was done about three decades ago. HIV is a global epidemic that poses an aggressive public health threat. The developing world suffers a greater percentage of the scourge with 68% of worldwide adult figures of people with HIV and AIDS residing in the developing countries. Moreover, 90% of worldwide figures of people living with HIV and AIDS also reside in developing countries. Heterosexual transmission makes up a large chunk of ...

Introduction

Crude acid phosphatase from wheat germ can be isolated by gentle aqueous extraction of pulped wheat germ to provide an enzyme-rich and vitamin-rich liquor, containing amongst other things Vit E, Vit B1 (thiamine), Vit B6 (pyridoxine), Vit B2 (riboflavin) and Vit B3 (niacin). This is generally spray dried at low temperatures and the dried product (fine powder) is sold as wheat germ extract.

The enzyme acid phosphatase is ubiquitous in nature and wheat germ provides a convenient source. It is a non-specific esterase utilising a variety of phosphate esters. It exists in three isoforms (I, II and Ill), each having pH optima ...