Inhibition College Essays Samples For Students

Assignment 2

PART A - (Total 15 marks)

Cephalexin and Gentamicin
The mechanism of action of amoxicillin is focused on the prevention of the synthesis of the bacteria’s cell wall through the binding and inhibiting of the cell wall transpeptidases (Katzung, Masters, and Trevor, 2012). Specifically, it attaches to the penicillin-binding protein 1A found in the cell wall of bacteria. Then, the agent disintegrates the lactam ring to allow the acylation of the penicillin-sensitive transpeptidase C-terminal domain. The formation of the cross-link of the linear peptidoglycan strands is prevented by the inactivation of transpeptidases. Since the third and last stage ...

Article critique

1. What study report is this?
Hayes, B. T., Harter, R. A., Widrick, J. J., Williams, D. P., Hoffman, M. A., & Hicks-Little, C. A. (2012). Lack of neuromuscular origins of adaptation after a long-term stretching program. Journal of Sports Rehabilitation, 21, 99-106.
2. Purpose and general rationale. What was the general purpose of the study? What questions does it raise?
The purpose of this study was to examine the possible neurological origin and adaptations in the Ia-reflex pathway that allows the increase the flexibility of ankle range of motion (ROM). This study evaluated the neurological changes occurring ...

Summary: The study titled: “The Role of Prefrontal Inhibition in Regulating Fascial Expression of Pain.”, examines the role of pre frontal cortex in the control of fascial expression of pain (Karmann et al.). Expression of pain is determined by a certain factor in the environment (like the availability of caregiver) and also on factors that exist within an individual. Expressing pain is a form of communicating once feelings to others. Understanding expressions may help in assessing the pain in a patient (Craig). Presently, assessment of pain in an individual, is done based on the verbalization of pain by the ...

In the medical field, there are constant inventions that are intended to improve the quality of care for patients. These interventions are based on qualitative and quantitative research whose results indicate the effectiveness of the practice on different patients. Patients living with medical conditions like Diabetes rely on these practices to make their lives better. The adoption of the interventions is based on how well the medical professions understand it and how it changes the lives of their patients. The following is a detailed look at one of the practices and how I would ensure its adoption in a ...

The human body consists of trillions of cells that work together synchronously for the maintenance of an organism. The metabolic needs of all the cells in the body are almost similar. For the well-being of a human body and the proper functioning of all the cells, constant internal environment needs to be maintained by providing the cells with oxygen and nutrients (Homeostasis and Regulation in the Human Body < OpenCurriculum, 2016)
The internal environment of the body is tissue fluid, which bathes all cells making up the body (Mader, 2016). The composition of the tissue fluid must always remain ...

Biology

Analysis of Sources
Lebrec, H., Ponce, R., Preston, B.D., Iles, J., Born, T.L. & Hooper, M. (2015). Tumor necrosis factor, tumor necrosis factor inhibition, and cancer risk. Current Medical Research and Opinion 31/3: 557-574. DOI: 10.1185/03007995.2015.1011778

This is a secondary source. Reasons are as follows: -

The research design is based on a literature review (Lebrec, Ponce, Preston, Iles, Born, & Hooper, 2015, p. 557).
The researchers have carried out a topic search in the Ovid Database system (Lebrec, Ponce, Preston, Iles, Born, & Hooper, 2015, p. 559).
The researchers have quoted work from Waters et. al, Grunhagen et. al. and Derorose et. al. to establish the efficacy of isolated limb perfusion ...

In humans and animals, sleep and rhythmic vivacity replace each other. However, to understand the extent, to which sleep is necessary for the functioning of the body, it is necessary to consider the fact that total sleep deprivation of people and animals carries much heavier consequences than starvation.
What is sleep? How it arises and why there is such a big need for it? Many scientists tried to answer this question. French researchers Legendre and Pieron in 1910 conducted experiments, from which they concluded: the cause of sleep - accumulation in the blood during the day of hypnotoxin or ...

(Author)

Regulation of Xiap Protein in Breast Cancer
Breast Cancer
Breast cancer is the type of cancer that develops in the tissues of the breast. Two most commonly reported types of breast cancer are “ductal carcinoma” and “lobular carcinoma”. Ductal carcinoma is initiated in the lining of the milk ducts, which are thin tubes involved in carrying of milk from lobules of the breast to the nipple. Ductal carcinoma can be in the form of Invasive ductal carcinoma (IDC) as well as Ductal carcinoma in situ (DCIS). IDC is the most commonly found type of breast cancer ...

Introduction

A scientific study was conducted to evaluate the effects of crude oil on different nitrifying prokaryotes. The researchers utilized ammonia-oxidizing bacteria and archaea to develop a bioassay. The study evaluated the ecological responses of these two groups of microorganisms on marine oil spills. Researchers found inhibition of nitrite production in all tested ammonia-oxidizing micro-organisms. The paper highlights the impact of crude oil spills on the environment. The paper also demonstrates the effects of phytoremediation to treat the oil spills. Many scientific studies had been conducted to evaluate the effects of phytoremediation (Using Nitrosopumilus maritimus and Nitrosococcus oceani) for crude oil ...

1. Motor pathways: Briefly describe important differences between the lateral and the medial (motor) systems

ANSWER:

The motor system is the corticospinal tract. The lateral part of the corticospinal tract decussates while the medial part does not. The lateral corticospinal tract controls limb muscles while the medial corticospinal tract controls the axial and trunk muscles. The lateral corticospinal tract carries contralateral fibers from the cerebral cortex to supply the limb muscles while the medial corticospinal tract carries ipsilateral fibers from the cerebral cortex to supply the axial and trunk muscles.

2. What is the main function of the basal ganglia?

ANSWER:

...

Recent developments and current trends in human longevity

Age-related diseases and aging have become one of the greatest challenges with respect to financial burden and social status. Based on current evidence and a review of over 100 years of scientific experience, the concept of aging has received criticism owing to growing population of elderly and age-related diseases that act as a burden to the economy. An international workshop entitled, ‘Interventions to Slow Aging in Humans: Are We Ready?’ was conducted in Italy with an objective to provide a consensus on the discovery and development of safe interventions for aging in humans with the help of biologist and ...

1. The researchers studied how humans act in the case of emergency individually or in a group when they are exposed to the inaction of other people, who also witness the same emergency. Experiments were carried out to test the following hypotheses:
Passive reactions of other witnesses, in this case, confederates, to an emergency situation will affect the behavior of an individual; therefore, he will be more unlikely to act than if he were the only witness of this emergency;
According to the second hypothesis, if a group of naïve subject witnesses face an emergency situation, two factors ...

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Introduction

Parkinson Disease (PD) is a very complicated neurodegenerative condition including the motor and non-motor manifestations that lead to neuronal loss. Currently, only symptomatic therapies are available but nothing is known yet to prevent this degenerative process. This is a multi-factorial condition with multiple risk factors that includes increasing age, genetic vulnerability, and environmental determinants. All these factors mutually play a role in the pathogenic process of PD. Medical sciences have achieved major advances in understanding the process working behind PD development that are Nigral Dopaminergic Apoptosis, Protein ...

When a person wants to lose weight, he just wants to get rid of excess fat. However, in the reality it often turns out that the majority of modern diets and training methods cannot burn fat. The result is that people together with fat lose muscle mass.

The Role of the Thyroid Gland

Low thyroid hormone level often causes a general slowing of the metabolic rate, including the inhibition of processes of fuel utilization by muscles, lack of power, increased sensitivity to cold and catarrhal diseases. Today low-carbohydrate ketogenic diets have high popularity. People suffering from insulin resistance may gain an advantage from them by ...

Question 1

For succinate oxidation to fumarate there is yield of 2H+ and 2 electrons; however, the process of the reaction skips one step thereby leading to 2 ATP. The resulting FADH2 electrons skips the first stage of oxidative phosphorylation by moving into the electron transport chain located in CoQ. This can be illustrated as NADH -> CoQH2. Consequently, there is 2 ATP forming stages found in the electron chain from CoQ to O2 used in this course (Schwender et al, 50). Indifferent to the first scenario, oxidation of malate to produce oxaloacetate results to NADH, with production of 2H+ and ...

The immune system has an immune arsenal that help in the combat of infections including the challenging viral infections (Iannello 2006). Upon infection by a virus, the host invariably reacts by activating its line of defenses. These immune defenses can fall into two main groups: the innate immune system (first line of defense) and adaptive immune response. The innate immune system is non-specific in nature, but the adaptive immune system is acquired following previous infections or vaccinations (Iannello 2006). However, viruses continue to undergo an evolution and have engineered strategies that evade the hosts’ immune antiviral responses. This paper examines ...

(Course No.)
(City & State)
Growing cells are located within defined environmental niches and any area outside the niche is very hostile. Because normal cells lack survival techniques, it leads to anoikis. The tumor development process strives when malignant cells escape from the local issues and resist anoikis. The cells of the immune system play a dual role of stimulating adaptive immune responses against tumor-specific antigens and at the same time promoting tumor angiogenesis and progression. This is through the support of the innate and inflammatory responses (Ravi et al., 2000).
Integrins are termed as a family of adhesion ...

Introduction: Glucagon-like peptide-1 (GLP-1) based therapy is a novel treatment for type 2 Diabetes. GLP-1 receptor agonists and inhibitors of dipeptidyl peptidase IV improve glycemic control. GLP-1 exerts multiple effects including modulation of a-cell proliferation, apoptosis and exogenesis. Inhibition of gastric emptying and food Intake with stimulation of glucose uptake by adipocytes has also Been reported.

Beneficial effects of GLP-1 on myocardial and endothelial functions. However, the mechanisms underlying these various effects are not fully understood. Therefore, we examined whether the GLP-1 analog liraglutide protects human umbilical vein endothelial cells (HUVECs) from the injurious effects of the proinflammatory cytokine tumor ...

THE SCIENCE OF FOOD

Cancer and nutrition – good nutrition is very important in the management of cancer and thus healthy eating habits are encouraged during this period. Tumors that develop in the stomach or intestines may, however, affect the way the body uses the food that is ingested and may not absorb all the food, although the patient may be seen to be eating enough food. The side effects that may affect eating when one has cancer include vomiting, dry mouth, constipation, mouth sores, loss of appetite among others.
Nutrition therapy is advised for cancer patients to help maintain a good quality life ...

Introduction

The large production of bisphenol A (BPA) in the world has been documented because of the increased usage of the same in various industries. The most critical industries that have been using this BPA include those manufacturing containers for foods and beverages, cigarette filters, thermal receipts as well as paper currency. With such a huge provision, it is critical that the basis of such developments only emanates from making the right choices over its uses because its production to a total of 2.7 million tons could be disastrous to the body. The main reasoning here is that the chemical ...

Abstract

Bipolar disorder is one of the various clinical disorders that affect millions of people worldwide. There is no known cause for the disorder though genetics and environment play a significant role in exacerbating it. This paper examines the journey of one Carrie Mathison, a CIA agent who suffers from bipolar disorder. Like other patients with bipolar disorder, Mathison experienced frequent maniac episodes. She also exhibited high-risk behaviors, which are characteristic of bipolar disorder patients. That behavior was evident in her lack of inhibition and excessive drinking. Mathison also exhibited psychotic behaviors, particularly when she saw herself as a heroine ...

Black Cohosh

Black cohosh is also known as black snakeroot (as the name appeared in the U.S. Pharmacopoeia in the year 1820), bugwort, columbine-leaved leontice, tall bugbane, cordate rattle top, rattleroot, macrotys, papoose root, and battleweed. Its Latin name is Actaea racemosa or Cimicifuga racemosa. Macrotys actaeoides is also a synonym for the drug (Frostburg State University, frostburg.edu). It belongs to the Ranunculaceae (buttercup) family (Kinghorn A 2). The plant was first described in 1690 in Phytographia by Leonard Plukenet as Christopheriana facie. Later in 1751, it was named as Actaea racemosa by Linnaeus. However, the name was later changed into ...

What part of this dilemma should a counselor point out is Yelena’s responsibility to acknowledge and address?

The sexual disconnect between James and Yelena is essentially a consequence of an absence in open and honest communication between them about sex, particularly in expressing their specific needs in relation to sex, which is referred to in psychological literature as ‘sexual self-disclosure’ (Tang, Bensman, & Hatfield, 2013; Litzinger & Gordon, 2005) or ‘dyadic sexual communication’ (Pazmany, et al., 2014). Yelena had been enduring an unsatisfactory sex with her husband for more than two decades because she decided not to communicate her needs on the mistaken notion that doing so is being unfeminine.
Yelena felt the dilemma between her need for ...

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Diuretics targets to lower sodium and water reabsorption that may lead to enhanced water excretion. The main aim of diuretics is to reduce the fluid volume inside the body and maintain the electrolyte and water equilibrium. These agents are used for managing the pathological conditions including hypertension and edema such as cardiac congestion failure, liver and kidney problems, and glaucoma. It also helps in processing and regulating the blood pressure by eliminating the excessive salt from the body which slows down the cardiac muscles to impel the ...

Summary: In the article titled, “Abnormal Cortex Plasticity in Juvenile Myoclonic Epilepsy”, the authors investigate the role of defective motor plasticity in the pathogenesis of Juvenile Myoclonic Epilepsy (Strigaro et al.). Prior to this study, JME was linked to motor cortex hyper-excitability and to the abnormal function of thalamic networks. This study, identifies a new mechanism that can cause JME, a common form of generalized epilepsy seen in children. The motor cortex plasticity was studied using an interesting technique called the Paired Associated Stimulation (PAS). The details of this technique are discussed in the methodology section. The role of ...

Temperament plays a significant role in the development of adjustments and social competence. The support for this theory emanates from a number of studies conducted in North America and Western Europe. However, most of the effects of temperament on development take place in the cultural context. Further, temperament makes a substantial contribution in the development of social functioning and peer relationships. I hold the opinion that temperament may play a significant role in influencing the behavior of people. However, the influence on behavior is likely to be constrained by the cultural and social context. For instance, a group of ...

Question 1

FAD is reduced to FADH2 in Succinate oxidation to fumarate through catalytic action of succinate dehydrogenase. The resulting FADH2 electrons skips the first stage of oxidative phosphorylation by moving into the electron transport chain located in CoQ. This can be illustrated as NADH -> CoQH2. Consequently, there is 2 ATP forming stages found in the electron chain from CoQ to O2 used in this course (Schwender et al, 50). Indifferent to the first scenario, oxidation of malate to produce oxaloacetate results to NADH consequently, the NADH produced electrons completes its movement in 3 ATP forming steps associated with chain ...

Vascular System: The New Frontier in Cancer Research

Vascular System: The New Frontier in Cancer Research
For the last 50 years, cancer treatment has been ruled by the fact that each type of tumor must be selected for specific cancer treatment. Thus, medics have concentrated in producing specific types of drugs for the treatment of certain types of cancer (1). The types of drugs used were specific to candidates affected. Nonetheless, cancer cells have high rate of mutation hence they are very unstable therefore some cells become resistant due to repeated drug use or exposure to chemotherapy. The high rate mutation causes the cells to be genetically ...

Behavioral Finance Insights: Personal Finance and Planning

Behavioral finance is one of the new paradigms in the financial theory that aims at anticipating and comprehending the psychological financial decision making, especially of individual investors in conjunction with the systematic implications of the decisions in question on the financial market. Very simply, the basic premise of behavioral finance follows that individual investors or entrepreneurs tend to deviate from acting rationally in a utility-maximizing manner something that usually leads to business failures in the long-run. Essentially, behavioral finance does not substitute the existing theories on investment and finance. In other words, it complements and attempts to improve on their ...

Re-uptake involves the reabsorption of neurotransmitters by any of the neurotransmitter receptors or transporters. The transporters involved are usually of pre-synaptic neurons. Re-uptake occurs after the neurotransmitter has transmitted a neural impulse. Re-uptake is very crucial in order for the normal functioning of synapses to take place. This is because it allows the neurotransmitters to be recycled, thereby regulating their levels in the synapse. This in turn dictates the length of time it takes for a signal - generated by neurotransmitter release - to last. Neurotransmitters are usually large hydrophilic molecules that cannot pass through the neuronal membranes. For this reason, ...

- The stromal cells that are found in the developing gonads of tetrapods begin from the medulla from the peritoneal wall and the cortex from inter-renal blastema or mesonephric. Hence the gonads have a dual origin.
- Spermatogenesis occurs in a syncytial complex because it involves the formation of sperm from undifferentiated cells that are first attached to rachis. Syncytial cell complex or syncytium result when cells with single nuclei fuse to for a cell with nucleus. Syncytial cell complex is vital in oogenesis in that it assists in the differentiation of cells. One other developmental model is vitellogenesis.
- ...

Chemistry can be described as the branch of science concerned with the substances of which matter is composed, the investigation of their properties and reactions, and the use of such reactions to form new substances.

The Mechanisms and Synthesis of Aspirin

Aspirin is also known as acetylsalicylic acid (ASA). It is a salicylate drug used as an analgesic (something that relieves pain without producing anesthesia or loss of consciousness) for minor aches and pains, as an anti-inflammatory drug, and as an antipyretic to suppress fever. (Vane & Bottling 2000)
The name “Salicylic acid’ was derived from salix, which is the willow family of plants. In ancient ...

The overall aim of the paper Studies of Interference in Serial Verbal Reactions by J. Ridley Stroop is to demonstrate how interference influences the reaction time of a given task. The paper presents an experimental work in the naming of colors while reading the names corresponding to the different colors. The time taken to name a color differs greatly when a color is given and the corresponding name turns out to be the name of the color as opposed to a scenario where the name of the color does not denote the color on which the name is written. Errors are bound to ...

Racial order reflects the procedure of setting individuals into unique gatherings focused around variety in phenotypic physical gimmicks of the face and body, for example, skin shade, hair color and composition, eye shape, nose width, and lip totality. Racial stereotyping, prejudice, and separation reflect the human inclinations to conceptualize and worth certain setups of phenotypic peculiarities in an unexpected way, and follow up on these contemplations and emotions in our associations with parts of racial classifications. A number of us, especially learners of partiality, can select from memory distinctive illustrations of racial inclination and its outcomes. In both plain ...

Introduction

In the recent past, the trend in human social behavior and temperament has been a critical determining factor of the course of many global systems. The influence of human social behavior to the global systems is unlimited. Elements of social behavior have an effect to the world economy, consumer preferences, politics, religion, education, health, nutrition and a myriad of other utterly significant global structures. The media plays a critical role in engineering the moral response to a given event . The perception and understanding of global social systems is currently greatly dependent on the output of the media. One social element that is of ...

2. Neurodegenerative disease resulting in mental and intellectual decline (alz.org).
3. Most common cause of dementia and progressively worsens leading to patient’s death.
4. Symptoms
a. Memory loss (alz.org).
b. Inability to solve daily tasks and problems
c.Confusion about place and time
d. Depression and social withdrawal
- Causes of AD
- i. Presence of Amyloid peptide oligomers and neurofibrillary tangles that result in damage and death of neurons.(Gravitz, 2011)
ii. Inherent Genetic predisposition. (APOE) allele 4, GSK3 and TREM2 are part of gene clusters associated with AD ( ...

Cocaine is an illicit drug that is made from the leaves of the coca plant. Cocaine can be manufactured in several. A common method involves copping the coca leaves and mixing this with ammonia and lime. Following this, the mixture is placed into barrels with diesel gasoline. The active component of cocaine dissolves into the gasoline and the gasoline is filtered out from the rest of the mixture that is discarded. Sulfuric acid is then mixed with the diesel mixture. This allows for the formation of cocaine sulfate. The cocaine sulfate is then mixed with more lime to neutralize ...

Parkinson’s disease was first described by James Parkinson in 1817 as the “shaking palsy”. A person with Parkinson’s disease suffers from continuous shaking tremors while they are at rest, a phenomenon known as “pill rolling” (Jankovic, 2008). There are several public figures that live with Parkinson’s disease including the actor Michael J. Fox, the boxer Muhammad Ali, and former Attorney General Janet Reno. While tremendous research efforts have uncovered many important aspects of this disease, it is still unclear what determines the onset of this disease. The majority of Parkinson disease cases are idiopathic, meaning that there ...

Introduction

The information provided by pharmacokinetics is important in the discovery of new drugs and in screening drug candidates. It helps in drug research and can determine the concentration of a drug present in the body. The discovery of new medicines not only depends on pharmacological activity but on pharmacokinetic parameters as well. Pharmacokinetics includes absorption, distribution, metabolism and execration (ADME). Absorption is the absorbing of a drug in the blood stream. There are two types of absorption, passive and active. The physico-chemical properties are responsible for passive transportation while the active transportation determines the binding of a molecule to the target site. ...

Background

Asthma is a chronic disease associated with inflammation of the lining of airway and obstruction of lung airflow. It usually involves an increase in the number of inflammatory cells, most commonly eosinophils and to some extent basophils, mast cells, macrophages. (Eds. Brunton, et al., 2009) Asthma, together with Chronic Obstructive Pulmonary Disease (COPD), is considered as one ofthe most common obstructive lung diseases characterized by expiratory airflow obstruction. (eds. Longo, et al., 2012)
An asthmatic patient usually presents with recurrent events of shortness of bright (SOB), chest tightness, and wheezing, “a high-pitched whistling sound when breathing caused by movement of ...

Section 1. Renal Excretion of Drugs and their Metabolites

Determine whether your drug is:
a) Primarily excreted unchanged (as the parent drug) in the urine (renally cleared)
b) Excreted in the urine principally as metabolites (metabolised; hepatically cleared)

Salbutamol is cleared through the urinary system, metabolizing through the inactive 4’-O-sulphate (phenolic sulphate). Within the urine (with a minor extraction method being faeces), both the salbutamol and the metabolite sulphate are excreted. In studies, urinary excretion of salbutamol has resulted in around 64% of a dose being excreted as unchanged salbutamol, with about 12% excreted as the sulphate conjugate (Spina, 2003).

Section 2. Drug Metabolism

For your drug:
a) discuss its metabolism noting the ...

1.0 Overview of urine formation
The kidney is the chief regulator of all body fluids primarily responsible for maintaining homeostasis (equilibrium) of fluids and electrolytes (salts) in the body[ CITATION LAK03 \l 2057 ]. The kidney has five main functions namely: regulation of fluid and electrolyte, regulation of acid-base balance, excretion of the waste products of protein metabolism, hormonal function and protein conservation. All kidney functions except the hormonal function are carried out through urine formation which involves three processes: filtration, re-absorption and secretion. These processes occur at different parts of the nephron, the basic functional unit of the ...

In this experiment, students were asked to accurately guess how allergic Mrs. X was to a particular type of food. Phase 1 allowed participants to randomly guess the allergy level of a food without any prior notice of how susceptible Mrs. X was to each food, only learning after they had guessed. The lack of reinforcement of the correct answer for A in phase 1 made it less likely to remember it in phase 2, whereas they had time to get the right answer in their minds for cue B.

This leads to the conclusion in the results that reinforcement is ...