Essays on Serum

‘Author’s name’

‘Institution’ Introduction Diabetes mellitus is defined by the World Health Organization (WHO) as a chronic disease characterized by the lack of insulin production by the pancreas or when the insulin produced by the body is not effectively utilized. Uncontrolled diabetes can result to hyperglycemia and may lead to severe damage to different body systems over time. Diabetes can damage the heart, blood vessels, eyes, kidneys, and nerves. (WHO, 2016) Type 1 diabetes occurs when the pancreas cannot produce enough insulin. Common symptoms of Type 1 diabetes include polyuria (frequent urination), polydipsia (thirst), and polyphagia (constant hunger). Other symptoms are ...

Cell culture is an in-vitro technique of cultivating cells under controlled conditions and in sterile conditions. The technique was first developed by Ross Harrison in 1907. During the process of cell culture, the cells are detached from their tissue of origin and segregated from each other, either by mechanical or enzymatic means. The detached cells are then transferred before culturing them in cell culture plate or flask. The first generation of producing cell through this method is called primary cell culture. The cells from the primary culture are transferred to a new culture plate with a fresh medium to ...

Abstract

In the last century, the knowledge of molecular biology has increased, opening new opportunities for addressing different diseases that have been affecting all populations. Before, genome and proteomic studies were seen as complicated field due to inability to get significance understanding of disease components at the molecular level. However, with the expansion of molecular biology, different techniques and tools have been developed to aid diagnosis and treatment of diseases. In this study, these tools have been investigated to understand how the knowledge on molecular diagnosis helps in detection and treatment of diseases. This study focused on the application of ...

(Author, Department, University,

Corresponding Address and email)

Hypernatremia and hyponatremia Hypernatremia and hyponatremia are among the most common electrolyte disorders in older people. Hypernatremia is caused by an increase in the concentration of the sodium in extracellular serum to more than 145 mEq per L. On the other hand, hyponatremia is caused by a decrease in the concentration of sodium in body, i.e. less than 135 mEq per L. Hyponatremia can be acute or chronic (Buttaro, 2013). Both hypernatremia and hyponatremia are commonly found clinical problems in critically ill patients. They are often asymptomatic, but in some patients their symptoms appear that can ...

Introduction

Zika virus also termed as ZIKV is a known to have gained worldwide attention, especially in the USA, South East Asia, and Australia. The Zika belongs to the Flaviviridae family which comes under the genus Flavivirus (Wikan & Smith. 2016). The Zika virus is spread though day time mosquitoes belonging to the Aedes family. Some of the most common mosquitoes to contain and spread Zika include A. aegypti and A. albopictus. The name of Zika originated in 1947 where it was first isolated from the Zika forest in Uganda. Based on evidence, the Zika virus was associated with varying viral ...

Overview: Overview: Antigen-antibody reactions are commonly used in immunological assays. In a traditional agglutination assay, the end product is a visible antibody-antigen complex that settles as visible particulate matter in the solution. In other cases, the reaction is invisible and wants the use of a specific enzyme or isotopic probes that can amplify the signal created by the antigen-antibody reaction, so that they can be detected with the naked eye or an ELISA/RIA reader1. Hemagglutination is a visible antigen -antibody assay in which soluble antibodies react with antigen on the surface of (red blood cell) RBC to form a ...

Cardiovascular Disease (CVD)

CVD includes all ailments of the heart and circulatory system, including angina and heart attack. Other CVD diseases include carditis, cardiomyopathy, and congenital heart disorder. Edmunds (2014), states that CVD develops when there is plaque build-up on vessel walls. The mechanism of CVD differs significantly depending on the disease involved. For instance, coronary artery ailment includes atherosclerosis, and may occur due to hypertension, smoking, overweight, high-fat diet or diabetes. Despite the high deaths caused by CVD, it is approximated that 90 percent of CVDs are preventable (McGill, McMahan, and Gidding, 2008). Atherosclerosis can be decreased by controlling the risk ...

Evaluate And Analyze The Paper I.E. Any Improvements, Why Things were done In the Relative Manner Cibely, O., Olivan, M., Jochen Springer, S. B., Tshiner, A., Figueras, M., & Toledo, M. (2012). Theophylline is able to partially revert cachexia in tumour bearing rats. Nutrition and metabolism.

Introduction/background

Explain the background to the research and how it came to being, name any previous articles used as the basis and explain why they are important, is the article building on previous work or aiming to resolve disagreements in previous studies, state the hypothesis being tested, what is the importance of the research question?

...

Introduction

In recent decades, trends in diets tailored to promote weight loss have resulted in a significant increase in the intake of protein, particular in people with overweight and obesity issues. Accordingly, researchers have questioned the benefits or risks linked to the habitual consumption of “dietary protein in excess of recommended intakes” (Martin et al., 2005). In general, the primary concern has involved the possibility that diets rich in protein may increase hyperfiltration and, hence, exacerbate renal damage. Nevertheless, the potential link between protein-rich diets and renal damage has also been questioned due to an absence of adequate clinical evidence. ...

Hypothyroidism is an endocrine disorder that results from thyroid hormonal deficiency. In the U.S. and other regions that have sufficient iodine consumption, autoimmune thyroid or the Hashimoto disease, normally causes hypothyroidism, while worldwide, iodine deficiency is the leading cause.

Pathophysiology

Hypothyroidism can be caused by malfunctioning of the hypothalamus, thyroid, or pituitary gland, as all of these result from the same “negative feedback mechanism” (McCann, 2011, p. 496). Despite belonging to the same mechanism the hypothalamus malfunction rarely causes hypothyroidism, and when it does, it is called ‘secondary hypothyroidism’. While the malfunction of the gland is referred to as ‘primary ...

Roseola also known as exanthema subitum or Sixth disease is a viral infection caused by human herpesvirus 6 (HHV-6) common in infants and young children. The pathognomonic sign of roseola infantum is the development of acute high fever and febrile seizure. Commonly after defervescence, a rubelliform eruption or rash occurs. A clinical exam is needed to diagnose roseola and the treatment is symptomatic (Caserta, 2014). To patients who are immunosuppressed, HHV-6 is a major cause of morbidity and mortality. HHV-6B can also cause CNS disease in these immunocompromised patients ("Roseola Infantum", 2016).

Pathophysiology

The transmission of the HHV-6 is airborne, ...

Diabetes in its generality is a condition that is associated with elevated blood sugar levels. When these elevations persist, the patient may experience cases of disturbance of other body systems and leading to poor functionality and ultimately a chronic condition that affects their quality of life. Type-2 diabetes (T2DM) is the most common type of diabetes whose impact on the health of populations has significantly been documented (Murrock, Taylor & Marino, 2013). Apparently, among the documented aspects of health disparities, T2DM is noted as one of the biggest health challenges for African Americans. The prevalence is even higher among women ...

The primary cause of emphysema is smoking cigarettes. CH and other patients with emphysema are at risk of the destruction of the alveoli and different cancers, coronary artery diseases, heart failures, cerebral vascular diseases, osteoporosis, and some anxiety diseases. Emphysema is a complex respiratory disease and is usually associated with various systemic symptoms. A low BMI and relatively high rates of dyspnoea contribute to impaired exercise tolerance and promote a dreadful forecast beyond the respiratory obstruction. Emphysema sufferers are vulnerable to some conditions such as lung cancer, anemia, depression, coronary artery diseases, and dysfunctional skeletal myopathy. COPD has been ...

Dehydration is the excessive loss of water by an individual which in turn reciprocates in the disruption of the normal bodily functions. This improper functioning of the body is mainly caused by the fact that the human body is in a constant state of losing fluids and it is always required that the lost water be replaced, however if not replaced, then complications may arise. The elderly in the nursing homes tend to be victims of dehydration mainly due various reasons such as being unable to speak out when they need to be given fluids and further inadequate supervision ...

Abstract

Worldwide, ovarian cancer is ovarian cancer is the sixth most diagnosed cancer and is responsible for the most deaths annually than any other disease of the female reproductive system. It has a poor prognosis because the symptoms are vague even into Stage IV of the disease. Epithelial ovarian cancer constitutes about 90% of diagnosed cases. Research has demonstrated that hormone therapy, chronic pelvic inflammation, and BRCA1 and BRCA2 germline pathogenic variants are factors in the etiology of ovarian cancer. BRCA1 and BRCA2 is also associated with breast cancer, pancreatic cancer, fallopian tube cancer, prostate cancer, and primary peritoneal cancer. ...

Monomorphic Ventricular Tachycardia

Cardiac arrhythmias often require immediate medical care that may include resuscitation (Ray, 2004). The diagnosis of cardiac arrhythmias can be challenging particularly in situations whereby the patient is asymptomatic and ECG findings are normal between symptomatic episodes (Cruickshank, 2008). Distinguishing between supraventricular and ventricular tachycardia is also a challenge (Australian Resuscitation Council, 2008). Cardiac arrhythmia should be suspected in patients with a history of syncope, near syncope, palpitations, and/or chest pain (Cruickshank, 2008). This paper will justify why monomophic ventricular tachycardia is the most likely diagnosis of a male patient who collapsed abruptly and has hypotension (BP 63/38), tachycardia ( ...

P.J is a 53 year old man who has had type 2 diabetes for which he was diagnosed two years ago. He has also had hyperthyroidism and obesity problems. P.J is a lawyer and says that he his job restricts him from having free time to do exercise or any light activity. He is a regular user of alcohol and uses five sticks of cigarette per day. He is however planning to quit alcohol in the next 12 months. He says that for the last three nights he has woken up at 4.00am due to elevated blood glucose levels ...

{Author Name [first-name middle-name-initials last-name]} {Institution Affiliation [name of Author’s institute]}

Diuretics targets to lower sodium and water reabsorption that may lead to enhanced water excretion. The main aim of diuretics is to reduce the fluid volume inside the body and maintain the electrolyte and water equilibrium. These agents are used for managing the pathological conditions including hypertension and edema such as cardiac congestion failure, liver and kidney problems, and glaucoma. It also helps in processing and regulating the blood pressure by eliminating the excessive salt from the body which slows down the cardiac muscles to impel the ...

Abstract

This paper discusses how exercise stimulates the release of growth hormone. Older people tend to have lower levels of the hormone. As a result, mechanisms have been formulated to help deal with the deficiency which includes inducing the growth hormone into the individual’s body. This, therefore, leads to the discussion of the exact mechanism through which the growth hormone facilitates exercise, maintains growth and repair of worn out muscles or even reverses the aging process among the aged. Also, the functions of IGF-I binding proteins during exercise and its importance in aiding the release of the GH is ...

Pregnancy presents a unique condition and it is of utmost importance by the care provider to conduct all the necessary assessments not only for the purposes of securing the health of the mother but also that of the unborn (London et al., 2015). The first weeks of pregnancy present a unique phase of pregnancy since most birth defects occur during these initial weeks. Examples of the defects include; neural-tube and congenital defects. This makes it necessary to conduct thorough and comprehensive assessment of the unborn and the mother so as to prevent the occurrence of these conditions. As such, ...

Based on the initial symptoms, the patient most likely suffers from hypothyroidism or low thyroid hormone disorder. Further clinical tests and an examination of the family’s medical history reveals that the particular disorder could be Hashimoto’s disease; also called Hashimoto thyroiditis. Hashimoto thyroiditis is classified as an autoimmune disease. In autoimmune disease, one's immune system attacks the body’s tissue specifically the thyroid gland (Skugor & Wilder, 2006, p.2). By attacking the thyroid gland, the disease reduces the gland’s ability to produce thyroid hormones of substantial quantity. This condition leads to hypothyroidism. Thyroid hormone deficiency presents with ...

Hypercalcemia refers to the condition where calcium levels are above normal in the blood. Presence of too much calcium in the blood may result to endless complications and defects to an individual’s body parts. No severe signs are experienced in the human body until the the accumulation of the calcium levels hits the abnormal levels. Patients with high levels of calcium in their blood stream will experience constant dehydration and this will lead to frequent intake of water hence constant urination (Marcocci & Cetani, 2011). This is as a result of the kidneys being involved in filtration of high ...

Introduction

Prenatal iron supplementation has been the customary recommendation in addressing maternal anemia especially in developing countries for over thirty years (West, et al., 2014). There is paucity of information regarding the correspondence between hemoglobin levels in pregnant women and iron supplementation. The limited information in this pertinent public health issue is more pronounced in developing countries as West, et al., (2014) opines. The main purpose of this research is thus to establish the efficacy of prenatal iron supplements on the hemoglobin levels of pregnant women in developing countries.

Research design

In order to achieve the study’s objective, the methodology will ...

Individuals with advanced age are prone to acquire a spectrum of illnesses due to a decline in their body functions. This group requires a thorough care management from the health care system to overcome further consequences. In such context, the present description deals with a topic entitled ‘Nutrition and Hydration in Older Adults’

Significance to nursing students:

This topic is important to nursing because nurse serve as the ideal candidates who could provide the care and warmth needed for the patients of this particular old age. In the nurse profession, geriatric nurses are special category of nurses who assist the older patients. The ...

Since the introduction of Antiretroviral Therapy (ART), the health prospect for the HIV-infected population has evolved considerably. The application of ART has led to a significant reduction in the rate of mortality for this group of people (Chastain et al., 2015). However, the number of deaths resulting from non-HIV-related diseases including cardiovascular diseases (CVD), hepatic disease, and cancer has taken the opposite turn. This paper evaluates the association between CVD and the administration of ART among HIV patients. A study in this area may be helpful in reducing the occurrence of CVD in the HIV-infected population. A prompt detection ...

Magnesium is an essential nutrient

Magnesium is a mineral which is of great abundance in the human body. Along with enzymes, it is important for protein synthesis, muscle regulation and a host of other important cellular factors such as oxidative phosporylation, energy production which involves production and utilization of ATP and glycolysis. Additionally, Magnesium is required to assist in different cellular processes such as DNA replication and transcription and RNA translation(Barbagallo, 2012). Magnesium is found usually in the bones and or in the soft tissues of humans. Next to Potassium, it is the most abundant ion in the body. The plasma actually contains ...

What are three major causes of chronic bronchitis?

The three major causes of chronic bronchitis are cigarette smoking, long time exposure to air pollutants (such as industrial or chemical fumes), and inhalation of toxic gasses (Madell, 2016).

What are the major pathologic airway changes are associated with chronic bronchitis?

Chronic bronchitis is the condition affecting human beings that cause a continuous irritation and inflammation of the lining of the bronchial tube. Bronchial tubes are airways that carry air to and from the lungs. Exposure to cigarette smoke, air pollutants, or toxic chemicals causes a persistent cough that leads to the formation of excessive amounts of sticky mucus in the airways that result in inflammation and fibrosis. The mucus blocks ...

Lis Rodriguez

Lab 1 ASA College Abstract Patau’s syndrome is a rare genetic disorder that involves trisomy 13. The condition is characterised by either an extra copy of the autosomal chromosome number 13 or a translocation to chromosome 13 from another chromosome. There are severe symptoms observed in the unborn and newborn children having this defect. Polydactyly, cleft lips, physical retardation, mental retardation, heart defects are few of the many symptoms. The disease can be diagnosed during gestation via screening methods followed by several analytical procedures like FISH, karyotyping and microarray on samples of blood and serum from the pregnant ...

Chemistry

2. The nano carrier needs to remain in suspension in H2O, PBS, human serum, etc. What type of polymer do you need to use to decorate the surface of the nanocarrier to achieve this goal? In order to maintain the nanocarrier in suspension in water, Phosphate-Buffered Saline (PBS), human serum a suitable solution a polymer is needed on its surface. The polymer used needs to accomplish three goals. The polymer needs to decorate the nanocarrier surface to enhance suspension and secondly, to prevent protein absorption. Another characteristic is that the polymer evades the immune system. PLGA poly(lactic-co-)glycolic ...

INTRODUCTION

The 6-month infant presents to the clinic with splenomegaly and lipemic samples at birth . Screening of complete blood count at birth was ordered, but could not be conducted, owing to the lipemic nature of samples. Subsequently, the patient was referred to a pediatric gastroenterologist, who examined the baby to be oversized with weight in 99th percentile, 81st percentile for height and 70th percentile for head circumference, and body mass index (BMI) in the 99th percentile. He exhibited multiple lipomas on one ear lobe, in the right eye, neck and abdomen. Abdominal examination presented a soft, nontender abdomen with splenomegaly ...

Hepatitis- A Review of Viral Disease

Abstract The liver is one of the key and principal organs of the body and virus of hepatitis potentially develops an inflammation of the liver due to an increase in particular enzymes. There are many types of hepatitis, but the commonly known virus is hepatitis A, B and C. Hepatitis has a long history since the time immemorial due to inadequate sanitary conditions. The infection of hepatitis A is related to picornavirus, and major symptoms include nausea, abdominal pain, fever, and anorexia. Moreover, the visitors traveling to endemic countries are at higher risk. Hepatitis B is related to ‘serum ...

Abstract

Growth hormone is one of the many hormones released in the human body. This paper discusses the relationship between the growth hormone and exercise. The exact mechanism through which the growth hormone facilitates exercise is discussed in the paper. It is noted that the growth hormone is released rapidly in young children and teenagers but the production slows down with age. Other factors such as gender, adipose and diet also play a huge role in regulating the release of the growth hormone. For that reason, it is recommended that the aged people should exercise more frequently to induce the ...

HCV or Hepatitis C virus infection has over 5 million people affected in US (Chak, et al., 2011) and over 120 million people worldwide hence a global health problem. This virus belongs to Hepacivirus genus and Flaviviridae family (Lindenbach, et al., 2007) with six genotypes and with more than seventy subtypes. In approximately 85% infected individuals it may be unresolved, hence representing a significant hepatocellular carcinoma and liver cirrhosis cause. It is viewed as commonest cirrhosis cause and chronic liver disease in the world. It also represents the main liver transplantation cause in USA, Europe, and Australia (Thimme, et ...

Immunogenic cell death: the role of SAGE

Immunogenic cell death: the role of SAGE

Introduction

Millions of cells are always being removed in the human body not only to regulate and coordinate the body’s biochemical pathways but also to keep the cells healthy. This particular systematic removal of cells occurs through a selective mechanism called cell death or apoptosis process. Apoptosis is not a new concept in the understanding of the biological workings of the body. This homeostatic death of body cells has been defined as a tolerogenic or a non-immunogenic event for many [1]. However, new discoveries have unearthed the existence of a different concept ...

Article Review

Synergistic effect of human plasma and antimicrobial peptidomimetics and antibiotics on pathogenic bacteria: The Application is a promising tool in enhancing the efficacy of future antibiotics. This work aims at summarizing and critiquing the Research in Microbiology journal research paper titled ‘Improved In vitro evaluation of novel antimicrobials: potential synergy between human plasma and antibacterial peptidomimetics, AMPs and antibiotics against human pathogenic bacteria’ .

Abstract

Condisering the hurdles of cytotoxicity and adverse side effects posed by existing antibiotics and the ever rising resistance of microorganisms to these compounds, there is a dire need for development of innovative antimicrobial peptidomimetics (AMPs) . Despite ...

Soy beans and their derivative products contain naturally occurring compounds called isoflavones. The isoflavones, occurring predominantly as daidzein and genistein, are not in actual sense estrogens, and, thus, they do not increase estrogen levels in blood when diets rich in them are taken. However, they have been noted to affect estrogen metabolism. Also known sometimes as phytoestrogens, because of producing weak-estrogen like effects in the body, isoflavones usually bind to estrogen receptor proteins, which in turn interact with one’s genetic materials in the cell. In this way, isflavones would be mimicking some of the physiological effects of the ...

After reviewing several topics, the population I have chosen to study is the local African-American diabetic population. This population is where I feel the greatest positive impact will occur. Currently employed with a nonprofit hospital, it is evident that many individuals lack health insurance and currently suffer from multiple, uncontrolled chronic medical issues. I have confidence in the fact that through teaching, the cycle of having uncontrolled chronic illnesses can be broken.

Aggregate Details

The aggregate chosen for the Capstone project will focus on the local African American diabetic population. The chosen population, largely located within the city of Ft. Pierce, ...

Immunogenic Cell Death: The Role of RAGE

Introduction Millions of cells are always being removed in the human bodyin order to regulate biological pathways and keep cells healthy through a particular mechanism called cell death or apoptosis. Through apoptosis, such homeostatic death of cells has been defined as a tolerogenic or a non-immunogenic event for many years [1]. However, during the past few years, scientists have discovered the occurrence of a different concept of cell death – immunogenic cell death (ICD), where the death of a cell stimulates a response from the immune system against antigens of a dead cell, and this mechanism of cell death may ...

Diabetes mellitus in itself is considered an endocrine issue. When determining the priority diagnoses for an admitted patient, however, it is important to consider taking an all-encompassing perspective with regards to the pathophysiology of each patient and address each issue accordingly. The priorities in the selected aggregate for diabetes mellitus are as follows: Firstly, there is the situation of unbalanced nutrition often evidenced by increased urinary output (or dilute urine), recent weight loss and a decrease in muscle tone, disinterest in eating, diarrhea and an increase in ketosis. Some of the pathophysiological factors that may have led up to ...

{Author Name [first-name middle-name-initials last-name]} {Institution Affiliation [name of Author’s institute]}

Pathophysiology and Aetiology

Acute renal failure or ARF means any abnormality with the function of kidneys. Kidney performs multiple functions thus ARF is also termed as acute renal injury (ARI). Now medicine and healthcare have advanced to a higher level integrated with different drug therapies and dialysis treatments though the mortality rate with such condition is still high; that is 50% of kidney patients and up to 85% of patients with other co-morbidities (Doenges, Moorhouse & Murr, 2014). The Pathophysiology of ARF includes a rapid fall in Glomerular Filtration Rate (GFR) ...

Introduction

Millions of cells are always being removed in the human body in order to regulate biological pathways and keep cells healthy through a particular mechanism called cell death or apoptosis. Through apoptosis, such homeostatic death of cells has been defined as a tolerogenic or a non-immunogenic event for many years [1]. However, during the past few years, scientists have discovered the occurrence of a different concept of cell death – immunogenic cell death (ICD), where the death of a cell stimulates a response from the immune system against antigens of a dead cell, and this mechanism of cell death may ...

DHEA:

Dehydroepiandrosterone, or DHEA, is a hormone the human body produces via the adrenal glands, which are above the kidneys. The exact effect of DHEA is not yet fully identified; however, it is believed to be a precursor of the female and male sex hormones, namely estrogen and testosterone, among others. Precursors are substances that the body converts into hormones.

The production of DHEA usually reaches its peak around the mid-20s and declines ever after. The same applies to estrogen and testosterone, whose production also declines with age. For that reason, if an individual wants to increase their hormone levels, it ...

Diabetes is a burning issue all over the world. World health organization has shown concerns on the prevalence and incidents of diabetes. In USA, 29.1 million people or 9.3% of the population; diagnosed or undiagnosed have diabetes. (CDC, 2012). As per National Diabetes Fact Sheet, 2011 215, 000 people in USA have type-I or type-II diabetes. Thus, diabetes is a disease penetrating all age groups. Treatment of diabetes has a few advancement in the recent past. Apart from general oral hypoglycemic agents and injectable insulin there are islet transplantation surgeries also available for diabetes. There is a wide scope of treatment of diabetes ...

Introduction

The field of medicine and pharmacy has over the recent past experienced tremendous growth with technological improvements making pharmacy and the analysis of drugs and characteristics of drugs much simpler. Drug analysis is a fundamental aspect of drug development. It is not confined to making improvements to drug but also assessing quality to ascertain their fitness for human consumption. Drugs are chemical compounds that are affected by a number of factors including temperature, moisture and contaminants among others. For this reason, technology has provided an analytical tool for analyzing the drugs.

Following the introduction of spectroscopy about half a century ago, ...

Introduction

Type 2 diabetes mellitus is distinguished by insulin resistance and a relative disorder in insulin secretion. The production and development of the disease is not completely understood and we find genetic factors as well as environmental factors affecting the insulin release. The disease is increasingly common and basically caused due to obesity and sedentary lifestyle. The chronic metabolic disorder affects both the insulin secretion and insulin action. It is the suppressed hepatic glucose production as well as lower insulin-mediated glucose uptake by the muscles that contribute equally to postprandial hyperglycemia.

The dominance of risk factors

Nearly 400 million people worldwide are affected by diabetes and ...

Hepatitis is one of the most serious causes of liver disorder and dysfunction, which is responsible for one to two million deaths a year. Hepatitis can occur as infectious or non-infectious. Although major causes of hepatitis include viruses, the other common causes are autoimmune liver disease, obesity, alcohol, tobacco consumption and certain other medications and herbs. Viral hepatitis is a viral-induced necroinflammatory disease of the liver caused by one of the hepatitis viruses, namely, Hepatitis A, Hepatitis B, Hepatitis C, Hepatitis D, Hepatitis E and Hepatitis G . Hepatitis and A and E are enterically transmissible viruses, while Hepatitis B, C and ...

Glade Bender JL, Lee A, Reid JM, Baruchel S, Roberts T, Voss SD, Wu B, Ahern CH, Ingle AM, Harris P, Weigel BJ, Blaney SM. Phase I pharmacokinetic and pharmacodynamic study of pazopanib in children with soft tissue sarcoma and other refractory solid tumors: a children's oncology group phase I consortium report. J Clin Oncol. 2013 Aug 20;31(24):3034-43.

This study describes a phase I clinical trial of “Pazopanib” in pediatric patients suffering from soft tissue sarcoma (STS). Pazonapib is an anti-angiogenic drug. It is a competitive inhibitor of ATP molecule1,2. It competes with the ‘substrate’ ...

PATIENT PROFILE

A 29 year old female Caucasian who has a 7-month history of heavy irregular menses, a 5-pound weight gain, constipation and history of decreased energy

SUBJECTIVE

There is a family history of thyroid disease in the patient's mother (Nissenson, A. R., 2009). Moreover, from the physical examination, the patient is overweight with a body mass index of 26.09 kg/m/m. Computed Tomography also shows enlargement of the thyroid gland without the presence of any nodule.

OBJECTIVE

Thyroid function test which includes serum thyrotropin concentrations and ; thyroxine, resin triiodothyronine uptake; free thyroxine index (FTI), Thyroxine, Thyroid stimulating Hormone are all serum parameters that are measured. clinical ...

- What did you learn that was beneficial to you? Be specific (i.e. give specific examples and references). Why did you find this beneficial? How will you apply what you have learned to your personal lifestyle?

In this class I have learned that eating healthy does not necessarily mean consuming less calories, skipping specific food groups, or skipping whole meals; but rather, eating healthy means consuming all types of foods in a balanced way. What surprised me most was that healthy eating actually means consuming many calories, but they have to be beneficial; they cannot be so called “empty calories.” Foods that are considered high in calories but still healthy are dried fruits and avocados. Cereal is a good breakfast option because of the high percentage of fiber and calcium. While consuming many healthy calories is ...

Introduction

This paper evaluates an article titled ‘Low serum adiponectin levels in children and adolescents with diabetic retinopathy.’ In the evaluation, the paper will determine the various aspects discussed by the article. These include, the hypothesis in the article, the procedures used in sampling, the independent and dependent variables and the alpha level. The paper also determines the outcome of the study by stating significant results, and whether the null hypothesis was accepted or rejected. Two questions that would be asked to the researcher are also stated. Additionally, the paper states alternative independent and dependent variables that can be ...

Part I: Nonparametric Methods

A sign test is a nonparametric method used in statistics for comparison of a single sample with a hypothesized value. The test is commonly used in situations where a paired t-test is traditionally applied. In the study, a sample of n patients is used in determining the preference for central nervous system saturation. The main objective of conducting the test was to determine whether a difference in preferences between the central nervous system saturation and the time of oxygen admission existed. Sign test was explored in paired data whereby central nervous system saturation data from ten patients was collected on admission and 6 hours after ...

IN POST- MENOPAUSAL WOMEN

INTRODUCTION The purpose of the study is to analyze the relationship between vitamin D intake in the post menopausal women in the age group of 55-60 years and osteoporosis. The elderly women have higher chances of losing vitamin D and thus suffer from multiple fractures and falls. Vitamin D is a fat soluble vitamin that is stored in the fat cells of the body. It helps in the absorption of calcium by the body. Calcium and other minerals like phosphates are required for maintaining bone health. Deficiency of Vitamin D leads to rickets in the young age and ...

[University’s name] According to Papadakis and McPhee (2015), chronic kidney disease affects more than 20 million individuals in the United States or every one individual out of nine. Most of the individuals remain unaware of their condition till it becomes full blown and has reached end-stage. According to Mohan (2010), chronic kidney disease or formerly known as chronic renal failure is a progressive and irreversible damage to renal parenchyma leading to depressed renal function. The major issues in CKD are acidosis, azotemia and uraemic syndrome.

ETIOLOGY & PATHOGENESIS:

All nephropathic entities can eventually lead to CKD but they are classified ...

Neupogen is a granulocyte colony-stimulating factor that is in man-made form. The bacterium that is used in making this drug is Escherichia coli. Granulocyte colony-stimulating factor substance is produced by stimulation of the body cells. Neupogen drug has been widely used and has shown great effectiveness previously in patients suffering from cancer. It is preferred to people fighting cancer since it can stimulate the replication of the white blood cells in the body mostly referred to as the neutrophils. The benefit of the production of more blood cells among these patients is because the latter reduces their body’s’ vulnerability ...

[University’s name] Electrolytes are charged particles that have the tendency to generate electrical potentials. Therefore, they are kept under strict check so that they remain within certain limits and don’t alter the internal hemodynamically stable milieu. But, during a diseased process or because of self-induction, these electrolytes may either become surplus or becomes alarmingly decreased. Such states can have deleterious often lethal effects on human life.

HYPOKALEMIA:

Signs and Symptoms: According to Papadakis and McPhee (2015), patients with hypokalemia may present with muscular weakness, fatigue, abnormal muscular cramps, paralytic ileus leading to constipation, decreased reflexes, hypercapnia, tetany ...

Clinical Presentation of CKD

According to the National Kidney Foundation, chronic kidney disease refers to the structural and functional abnormalities of kidneys over a period of three months demonstrated by either the damage of kidneys or Glomerular filtration rate lesser than 60mL per minute per 1.73 meter square . The clinical presentation of CKD is difficult to detect due to the uncommon symptoms in patients with GFR greater than 35 percent. However, when the percentage of GFR is less than 35 percent, a variety of complications associate with the disorder, such as hematologic, metabolic, psychiatric and cardiovascular issues occur . In such situations, clinical presentation depends on ...

Biology of Disease

Mode of action of;- Dexamethasone The Glucocorticoid receptors are discovered intracellularly in all tissues. They enter cells through inactive dispersion and structure a complex with a receptor protein (Rhodes & Hartnoll, 2002, P.10). This intricate then experiences an irreversible enactment and enters the cell core, where it ties to the DNA, hence prompting organic impacts instigated by these hormones, which include expanded hepatic gluconeogenesis, as well as expanded lipolysis (Ahmed, 2007, P.13). Dexamethasone is utilized to treat numerous provocative and immune system conditions, for example, rheumatoid joint pain and bronchospasm. Idiopathic thrombocytopenic purpura, an abatement in quantities of ...

Isoforms of Dj-1 / Park7 Protein and Gp100

Isoforms of DJ-1 / Park7 protein and gp100 DJ-1 is simply a multifunctional protein that has a very crucial importance in oxidative stress, synucleinopathies such as Parkinson disease and cell death. Levels of DJ-1 generally decreases in cerebrospinal fluid, but they do not have a different composition in human plasma especially with patients with Parkinson illness. The total amount of DJ-1 has their attributes in the red blood cells, and they have the potential of being biomarkers of the Parkinson disease. In determining whether DJ-1 can be used as a biomarker of PD severity or PD diagnosis, we check on its abundance ...

Prognostic Cancer Biomarkers

The genetic diversity associated with cancer cells are shocking huge; and identifying a suitable prognostic marker is a real challenge. Prognostic cancer markers aims to evaluate objectively a patient’s overall outcome, response to treatment and chances of cancer recurrence. Prognostic markers can also help to select patients for a particular treatments and help predict the beneficial effect of the therapy. DNA, RNA, epigenetic patterns, signaling pathways, proteins, and metabolic biomolecules have been used as prognostic cancer markers. (Mehta et al., 2010)

Given below are few prognostic biomarkers commonly used in cancer medicine:

1. Beta tubulin: Beta tubulin regulates microtubule assembly in the cell. Class III tubulin are expressed by tumor of both neuronal ...

Quantitative Article Critique

Methods, Results, Data Analysis and Findings The quantitative research article chosen to be discussed was entitled Predictive Values of Semi-Quantitative Pro-Calcitonin Test and Common Biomarkers for the Clinical Outcomes of Community-Acquired Pneumonia. The respondent population was mainly composed of people who have been hospitalized as a result of having been diagnosed with Community Acquired Pneumonia between August 2010 and October 2012 using the semi-quantitative serum PCT Test. The objective of the research was to determine whether there is an existing relationship between the semi-quantitative serum pro-calcitonin (PCT) test (BRAHMS PCT-Q) and the clinical outcomes of patients with community acquired ...